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癌性膵液を用いたサブトラクティブ免疫法による新規単クローン抗体の作製と応用

Research Project

Project/Area Number 21659151
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Laboratory medicine
Research InstitutionFukuoka University

Principal Investigator

中島 学  福岡大学, 薬学部, 教授 (50198074)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords癌 / 膵液 / 抗体 / 診断 / 免疫学
Research Abstract

22年度における本研究は、21年度に樹立したモノクローナル抗体(2P-1-2-1,2P-1-17-1,6P-3-2-4,7p-9-11-6)が認識する抗原の解析を進めると共に、上記免疫方法を用いてヒト肝外胆管がん細胞株特異的モノクローナル抗体2種類(a2-H1-B12,a6-A11-D1)を新規に樹立した。
研究成果として、第69回日本癌学会学術総会にて3演題(1)The utility of novel antibodies in pathological diagnosis of pancreatic neoplasm(研究協力者と共同発表)、(2)Approaches to establish new monoclonal antibodies specific for cancerous pancreatic juice by subtractive immunization(3)Establishment of monoclonal antibodies specific for extrahepatic bile duct carcinoma by subtractive immunization、日本薬学会第131年会に2演題の計5演題を発表し、これらの新規モノクローナル抗体の臨床的有用性を示した。
また、6P-3-2-4の英文論文(Novel monoclonal antibodies against pancreatic juice from pancreatic cancer patients and their possible application in differential diagnosis)を投稿し受理された(International Journal of Molecular Medicine)。また、a2-H1-B12,a6-A11-D1の英文論文(Novel monoclonal antibodies specific for the extrahepatic bile duct carcinoma cell line (KMBC))も投稿準備が終了した。

Report

(2 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] Novel monoclonal antibodies against pancreatic juice from pancreatic cancer patients and their possible application in differential diagnosis

    • Author(s)
      Masato Hamabashiri
    • Journal Title

      International Molecular Medicine

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 膵液内膵癌特異的分子に対するモノクローナル抗体の樹立と抗原解析2011

    • Author(s)
      濱走優人
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝外胆管がん特異的モノクローナル抗体の樹立2011

    • Author(s)
      大長亜矢
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] The utility of novel two antibodies in pathological diagnosis of pancreatic neoplasm2010

    • Author(s)
      安元真希子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Approaches to establish new monoclonal antibodies specific for cancerous pancreatic juice by subtractive immunization2010

    • Author(s)
      濱走優人
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Establishment of monoclonal antibodies specific for extrahepatic bileduct carcinoma by subtractive immunization2010

    • Author(s)
      大長亜矢
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] subtractive immunization 法による新規抗膵癌モノクローナル抗体の樹立の試み2010

    • Author(s)
      濱走優人
    • Organizer
      日本薬学会130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] subtractive immunization 法による肝外胆管がん特異的モノクローナル抗体の作製の試み2010

    • Author(s)
      大長亜矢
    • Organizer
      日本薬学会130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Approaches to establish new monoclonal antibodies specific for cancerous pancreatic iuice by subtractive immunization2009

    • Author(s)
      濱走優人
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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