| Project/Area Number |
21659160
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
MURE Kanae 和歌山県立医科大学, 医学部, 講師 (90268491)
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Tatsuya 和歌山県立医科大学, 医学部, 公衆衛生学教授 (20150310)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | 予防医学 / マイクロRNA / アポトーシス / 紫外線 / 発がん予防 / 細胞内シグナル伝達 / 食品由来物質 / 突然変異 / DNA修復 / シグナル伝達 |
|---|
| Research Abstract |
To construct model cell lines for cancer development, profiling the microRNA, a small non-coding RNA (less than 22 bases) which has a function of regulating gene expression, and proteomic analysis were performed. Human keratinocytes were exposed to UV-B, and miRNA related to apoptosis (programming cell death) and DNA repair were analyzed.
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