Biomarkers and Gene-Environment Interaction in Irritable Bowel Syndrome

• Project/Area Number: 21659178
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: FUKUDO Shin 東北大学, 大学院・医学系研究科, 教授 (80199249)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,300,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 脳腸相関 / 過敏性腸症候群 / バイオマーカー / 消化管知覚 / 消化管運動 / 遺伝子 / 炎症 / ストレス

Research Abstract

Modern society needs keys to cope with stress-related disorders of which irritable bowel syndrome(IBS)is representative one. The purpose of this study is clarify the pathophysiology of gene-environment interaction including psychosocial factors, gut microbiota, and biomarkers in IBS. Results indicated distinct abnormalities in gut microbiota and their products, consistent effects of stress, some cytokines, and susceptible genes including serotonin-related genes. Further studies on gene-environment interaction in this issue are warranted

Research Products

• [Journal Article] Serotonin transporter gene promoter polymorphism and alexithymia (2012)
  • Author(s): Kano M, Mizuno T, Kawano Y, Aoki M, Kanazawa M, Fukudo S
  • Journal Title: Neuropsychobiology Volume: 65(2) Pages: 76-82
  • Peer Reviewed
• [Journal Article] Serotonin transporter gene promoter polymorphism and alexithymia (2012)
  • Author(s): Kano M, Kanazawa M, et al
  • Journal Title: Neuropsychobiology Volume: 65 Issue: 2 Pages: 76-82
  • DOI: 10.1159/000329554
  • Peer Reviewed
• [Journal Article] Validation of Japanese version of comorbid conditions questionnaire(CCQ-J)and recent physical symptoms questionnaire (RPSQ-J) (2011)
  • Author(s): Shinozaki M, Kanazawa M, Palsson OS, Sagami Y, Endo Y, Hongo M, Drossman, DA, Whitehead WE, Fukudo S
  • Journal Title: Internal Medicine Volume: 50(5) Pages: 375-380
  • NAID: 130000649846
  • Peer Reviewed
• [Journal Article] Lifestyle and psychological factors related to irritable bowel syndrome in nursing and medical school students (2011)
  • Author(s): Okami Y, Kato T, Nin G, Harada K, Aoi W, Wada S, Higashi A, Okuyama Y, Takakuwa S, Ichikawa H, Kanazawa M, Fukudo S
  • Journal Title: J Gastroenterol Volume: 46(12) Pages: 1403-1410
  • NAID: 10030295293
  • Peer Reviewed
• [Journal Article] Lifestyle and psychological factors related to irritable bowel syndrome in nursing and medical school students (2011)
  • Author(s): Okami Y, Kato T, Nin G, Harada K, Aoi W, Wada S, Higashi A, Okuyama S, Ichikawa H, Kanazawa M, Fukudo S.
  • Journal Title: J Gastrointestinal Volume: 46 Issue: 12 Pages: 1403-1410
  • DOI: 10.1007/s00535-011-0454-2
  • NAID: 10030295293
  • Peer Reviewed
• [Journal Article] Validation of the Japanese Version of Comorbid Conditions Questionnaire (CCQ-J) and Recent Physical Symptoms Questionnaire (RPSQ-J) (2011)
  • Author(s): Shinozaki M, Fukudo S, et al
  • Journal Title: Internal Medicine Volume: 50 Issue: 5 Pages: 375-380
  • DOI: 10.2169/internalmedicine.50.4589
  • NAID: 130000649846
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome (2010)
  • Author(s): Tana C, Umesaki Y, Imaoka A, Handa T, Kanazawa M, Fukudo S
  • Journal Title: Neurogastroenterol Motil Volume: 22(5) Pages: 512-519
  • Peer Reviewed
• [Journal Article] Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. (2010)
  • Author(s): Tana C, Fukudo S, et al.
  • Journal Title: Neurogastroenterol Motil Volume: 22 Pages: 512-519
  • Peer Reviewed
• [Journal Article] High-sensitive C-reactive protein may be one of blood biomarkers for visceral hypersensitivity in irritable bowel syndrome (IBS) (2009)
  • Author(s): Kanazawa M, et al.
  • Journal Title: Gastroenterology 136(S1)
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Kanazawa M, Fukudo S
  • Journal Title: Is colonic hypersensitivity really a biological marker of irritable bowel syndrome (IBS)? A role of visceral sensitivity on pathophysiology of IBS. Chapter IV. In ; Irritable Bowel Syndrome(Driggers J, Pellegrino C, edts.)(Nova Science Publishers) Pages: 1-8
• [Presentation] Inivited Lecture : Worldwide Reporting : Epidemiology of FGID : Symptoms Reporting Tendency, Perceptions/Behavior and Illness in that Region : Japan and Asia. Mini Symposium : Cross Cultural (2011)
  • Author(s): Fukudo S
  • Organizer: The 9th International Symposium on Functional Gastrointestinal Disorders
  • Place of Presentation: Milwaukee, USA
  • Year and Date: 2011-04-10
• [Presentation] Worldwide Reporting : Epidemiology of FGID : Symptoms Reporting Tendency, Perceptions/Behavior and Illness in that Region : Japan and Asia.Mini Symposium : Cross Cultural (2011)
  • Author(s): Fukudo S, et al
  • Organizer: The 9th International Symposium on Functional Gastrointestinal Disorders
  • Place of Presentation: Milwaukee, USA
  • Year and Date: 2011-04-10
• [Presentation] Invited Lecture : Gene, Environment, and Brain-Gut Interactions in Irritable Bowel Syndrome. Topics on Functional Gastrointestinal Disorders (2010)
  • Author(s): Fukudo S
  • Organizer: The First Asian Pacific Gastroenterology Topic Conference
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-11-27
• [Presentation] Gene, Environment, and Brain-Gut Interactions in Irritable Bowel Syndrome. (2010)
  • Author(s): Fukudo S.
  • Organizer: The First Asian Pacific Gastroenterology Topic Conference
  • Place of Presentation: Tokyo
  • Year and Date: 2010-11-27
• [Presentation] High-sensitive C-reactive protein may be one of blood biomarkers for visceral hypersensitivity in irritable bowel syndrome(IBS) (2009)
  • Author(s): Kanazawa M, Tana C, Watanabe S, Palsson OS, Whitehead WE, Fukudo S
  • Organizer: The 110th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Chicago, USA
• [Presentation] High-sensitive C-reactive protein may be one of blood biomarkers for visceral hypersensitivity in irritable bowel syndrome (IBS) (2009)
  • Author(s): Kanazawa M, et al.
  • Organizer: The 110th Annual Meeting of American Gastr oenterological Association
  • Place of Presentation: Chicago, USA
• [Book] 福土審. 過敏性腸症候群(irritable bowel syndrome : IBS)., 消化器疾患最新の治療2011-2012 (2011)
  • Author(s): 菅野健太郎, 上西紀夫, 井廻道夫
  • Publisher: 南江堂, 東京
• [Book] 過敏性腸症候群(irritable bowel syndrome : IBS)消化器疾患最新の治療2011-2012(菅野健太郎,上西紀夫,井廻道夫編) (2011)
  • Author(s): 福土審
  • Publisher: 南江堂
• [Book] 福土審. 消化器疾患:過敏性腸症候群., 今日の診療のために. ガイドライン外来診療 (2010)
  • Author(s): 日経メディカル開発, 東京
  • Publisher: 日経メディカル開発
• [Book] 消化器疾患:過敏性腸症候群.泉孝英編.今日の診療のために.ガイドライン外来診療 (2010)
  • Author(s): 福土審
  • Publisher: 日経メディカル開発
• [Book] Is colonic hypersensitivity really a biological marker of irritable bowel syndrome(IBS)? A role of visceral sensitivity on pathophysiology of IBS. Chapter IV. In ; Driggers J, Pellegrino C, edts., Irritable Bowel Syndrome (2009)
  • Author(s): Kanazawa M, Fukudo S
  • Publisher: Nova Science Publishers
• [Remarks]
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• [Remarks]
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• [Remarks]
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