Analysis of molecular link between Alzheimer' s disease and diabetes mellitus
| Project/Area Number |
21659179
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UCHIO Kozue 医薬基盤研究所, 生命資源研究部, 研究員 (70373397)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Naoyuki 大阪大学, 医学系・研究科, 寄附講座准教授 (70372612)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | アルツハイマー病 / 血管 / βアミロイド / 血液脳関門 / 周辺症状 / 炎症 / インターロイキン-6 / 糖尿病 / ベータ・アミロイド / インスリン・シグナリング |
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| Research Abstract |
Inflammation might be involved in the molecular link between Alzheimer' s disease and diabetes mellitus. We showed that the increase in brain inflammatory cytokine(interleukin-6) level was significantly higher in Alzheimer APP-Tg than in WT mice after peripheral LPS injection. Blood-brain barrier(BBB) became more permeable in APP-Tg mice during peripherally evoked inflammation, suggesting the increased vulnerability of BBB to inflammation in this animal model of AD. These findings might support the hypothesis that inflammation is involved in the molecular link between Alzheimer' s disease and diabetes mellitus.
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Report
(4 results)
Research Products
(91 results)
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[Journal Article] HIG1, a novelregul ator of mitochondrialγ-secretase, ma intains normal mitochondrial function2012
Author(s)
Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
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Journal Title
FASEB J
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function2012
Author(s)
Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
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Journal Title
FASEB J
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance2010
Author(s)
Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
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Journal Title
The Journal of Biological Chemistry
Volume: 285
Pages: 22091-102
Related Report
Peer Reviewed
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[Presentation] Possible mutual interaction between diabetes mellitus and Alzheimer' s disease : Generation of novel transgenic mice models of Alzheimer' s disease with diabetic conditions2009
Author(s)
Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita
Organizer
ICAD(International Conference on Alzheimer' s Disease) 2009
Place of Presentation
Vienna, Austria
Year and Date
2009-07-15
Related Report
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[Presentation] Possible mutual interaction between diabetes mellitus and Alzheimer's disease : Generation of novel transgenic mice models of Alzheimer's disease with diabetic conditions2009
Author(s)
Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
Organizer
ICAD (International Conference on Alzheimer's Disease) 2009
Place of Presentation
Vienna, Austria
Year and Date
2009-07-15
Related Report
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