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Analysis of molecular link between Alzheimer' s disease and diabetes mellitus

Research Project

Project/Area Number 21659179
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionOsaka University

Principal Investigator

MORISHITA Ryuichi  大阪大学, 医学系・研究科, 寄附講座教授 (40291439)

Co-Investigator(Kenkyū-buntansha) UCHIO Kozue  医薬基盤研究所, 生命資源研究部, 研究員 (70373397)
Co-Investigator(Renkei-kenkyūsha) SATO Naoyuki  大阪大学, 医学系・研究科, 寄附講座准教授 (70372612)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsアルツハイマー病 / 血管 / βアミロイド / 血液脳関門 / 周辺症状 / 炎症 / インターロイキン-6 / 糖尿病 / ベータ・アミロイド / インスリン・シグナリング
Research Abstract

Inflammation might be involved in the molecular link between Alzheimer' s disease and diabetes mellitus. We showed that the increase in brain inflammatory cytokine(interleukin-6) level was significantly higher in Alzheimer APP-Tg than in WT mice after peripheral LPS injection. Blood-brain barrier(BBB) became more permeable in APP-Tg mice during peripherally evoked inflammation, suggesting the increased vulnerability of BBB to inflammation in this animal model of AD. These findings might support the hypothesis that inflammation is involved in the molecular link between Alzheimer' s disease and diabetes mellitus.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (91 results)

All 2012 2011 2010 2009 Other

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (61 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Oral Glucose Loading Modulates PlasmaAβLevel in Alzheimer DiseasePatients Potential Diagnostic Method for Alzheimer Disease2012

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hisahiro Yu, Atsushi Moriguchi, Hiromi Rakugi, and Ryuichi Morishita
    • Journal Title

      Dementia and GeriatricCognitive Disorders

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse2012

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi and Ryuichi Morishita
    • Journal Title

      Neuroscience

      Volume: 186 Pages: 110-119

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual effects of statins on Abeta metabolism : Up-regulation of degradation of APP-CTF and Abeta clearance2012

    • Author(s)
      Naoyuki Sato, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
    • Journal Title

      Neurodegenerative diseases

      Volume: (in press)

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Central Nervous System Periostin in Cerebral Ischemia2012

    • Author(s)
      Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, and Morishita R
    • Journal Title

      Stroke

      Volume: 43 Pages: 1108-1114

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] HIG1, a novelregul ator of mitochondrialγ-secretase, ma intains normal mitochondrial function2012

    • Author(s)
      Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
    • Journal Title

      FASEB J

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral Glucose Loading Modulates Plasma Aβ Level in Alzheimer Disease Patients : Potential Diagnostic Method for Alzheimer Disease2012

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hisahiro Yu, Atsushi Moriguchi, Hiromi Rakugi, Ryuichi Morishita
    • Journal Title

      Dementia and Geriatric Cognitive Disorders

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse2012

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi, Ryuichi Morishita
    • Journal Title

      Neuroscience

      Volume: 186 Pages: 110-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Central Nervous System Periostin in Cerebral Ischemia2012

    • Author(s)
      Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, Morishita R
    • Journal Title

      Stroke

      Volume: 43 Pages: 1108-14

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function2012

    • Author(s)
      Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
    • Journal Title

      FASEB J

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms linking diabetes mellitus and Alzheimer disease : beta-amyloid peptide, insulin signaling, and neuronal function2011

    • Author(s)
      Takeda S, Sato N, Rakugi H, Morishita R
    • Journal Title

      Mol Biosyst.

      Volume: 7(6) Pages: 1822-1827

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Experimental and clinical application of plasmid DNA in the field of central nervous diseases2011

    • Author(s)
      Shimamura M, Sato N, Morishita R
    • Journal Title

      Curr Gene Ther.

      Volume: 11(6) Pages: 491-500

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms linking diabetes mellitus and Alzheimer disease : beta-amyloid peptide, insulin signaling, and neuronal function2011

    • Author(s)
      Takeda S, Sato N, Rakugi H, Morishita R
    • Journal Title

      Mol Biosyst

      Volume: 7(6) Pages: 1822-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental and clinical application of plasmid DNA in the field of central nervous diseases2011

    • Author(s)
      Shimamura M, Sato N, Morishita R
    • Journal Title

      Curr Gene Ther

      Volume: 11(6) Pages: 491-500

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus : a missing link to therapeutic potential.2010

    • Author(s)
      Sato N, Takeda S, Uchio-Yamada K, Ueda H, Fujisawa T, Rakugi H, Morishita R.
    • Journal Title

      Current Aging Science

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance2010

    • Author(s)
      Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 285 Pages: 22091-102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma β-amyloid as potential biomarker of Alzheimer disease : possibility of diagnostic tool for Alzheimer disease2010

    • Author(s)
      Takeda S, Sato N, Rakugi H, Morishita R.
    • Journal Title

      Molecular BioSystems

      Volume: 6 Pages: 1760-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse with diabetes2010

    • Author(s)
      Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
    • Journal Title

      Proceeding of National Academy of Sciences of United States of America

      Volume: 107 Pages: 7036-41

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes2010

    • Author(s)
      Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
    • Journal Title

      Proceedings of National Academy of Sciences of United States of America. (In press.)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin Receptor Blocker Prevented b-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling2009

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru S hinohara, Kazue, Niisato, Masanobu Kano, Toshio Ogihara, Hiromi Rakugi and Ryuichi Morishita
    • Journal Title

      Hypertension

      Volume: 54 Pages: 1345-1352

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ryuichi Morishita, Validation of Aβ1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease2009

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Kazue Niisato, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, Masanobu Kano
    • Journal Title

      Brain Res

      Volume: 1280 Pages: 137-147

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alzheimer disease-associated peptide, amyloid beta4O, inhibits vascular regeneration with induction of endothelial autophagy.2009

    • Author(s)
      Hayashi S, Sato N, Yamamoto A, lkegame Y, Nakashima S, Ogihara T, Morishita R.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 29

      Pages: 1909-1915

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor blocker prevented beta-amyloid-induced cogniti impairment associated with recovery of neurovascular coupling.2009

    • Author(s)
      Takeda S, Sato N, Takeuchi D, Kurinami H, Shinohara M, Niisato Kano M, Ogihara T, Rakugi H, Morishita R.
    • Journal Title

      Hypertension. 54

      Pages: 1345-1352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of Abetal-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease.2009

    • Author(s)
      Takeda S, Sato N, Niisato K, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Kano M, Morishita R.
    • Journal Title

      Brain Res. 1280

      Pages: 137-147

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor blocker prevented beta-amyloid-induced cogniti impairment associated with recovery of neurovascular coupling.2009

    • Author(s)
      Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
    • Journal Title

      Biochem Biophys Res Commun. 385

      Pages: 193-197

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Statins up-regulate APP-CTF degradation and Abeta clearance2012

    • Author(s)
      Naoyuki Sato, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      KEYSTONE SYMPOSIA
    • Place of Presentation
      Colorado, USA
    • Year and Date
      2012-02-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 新規マイクロダイアリシス法開発とアルツハイマー病研究への応用2011

    • Author(s)
      里直行、武田朱公、樂木宏実、森下竜一
    • Organizer
      第15回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] インスリン抵抗性と認知症2011

    • Author(s)
      里直行
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] インスリン抵抗性と認知症2011

    • Author(s)
      里直行
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルツハイマー病における血液脳関門の破綻による炎症の脳内への波及増幅2011

    • Author(s)
      里直行、武田朱公、樂木宏実、森下竜一
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] PATHOLOGICAL INTERACTION BETWEEN ALZH EIMER DISEASE ANDDIABETES MELLITUS2011

    • Author(s)
      Naoyuki Sato, Shuko Takeda, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      Grobal Alzheimer' s Research Summit
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] PATHOLOGICAL INTERACTION BETWEEN ALZHEIMER DISEASE AND DIABETES MELLITUS2011

    • Author(s)
      Naoyuki Sato, Shuko Takeda, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      Grobal Alzheimer's Research Summit
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of a novel microdialysis method to analyze molecules in brain interstitial fluid2011

    • Author(s)
      Naoyuki Sato, Shuko Takeda, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      第34回日本神経科学大会Neuroscience
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of a novel microdialysis method to analyze molecules in brain interstitial fluid2011

    • Author(s)
      Naoyuki Sato, Shuko Takeda, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      第34回日本神経科学大会(Neuroscience2011)
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認知症を防ぐための降圧療法2011

    • Author(s)
      森下竜一
    • Organizer
      第2回日本血管性認知障害研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 認知症を防ぐための降圧療法2011

    • Author(s)
      森下竜一
    • Organizer
      第2回日本血管性認知障害研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] CHANGE IN PLASMA BETA-AMYLOID LEVEL AFTER GLUCOSE LOADING : A POSSIBLE BIOMARKER FOR ALZHEIMER DISEASE2011

    • Author(s)
      Naoyuki Sato, Shuko Takeda, Mari Ueda, Hisahiro Yu, Atsushi Moriguchi, Kozue Uchio-Yamada, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      AAIC(Alzheimer Association International Conference) 2011
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-18
    • Related Report
      2011 Final Research Report
  • [Presentation] CHANGE IN PLASMA BETA-AMYLOID LEVEL AFTER GLUCOSE LOADING : A POSSIBLE BIOMARKER FOR ALZHEIMER DISEASE2011

    • Author(s)
      Naoyuki Sato, Shuko Takeda, Mari Ueda, Hisahiro Yu, Atsushi Moriguchi, Kozue Uchio-Yamada, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      AAIC (Alzheimer Association International Conference) 2011
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認知症に対する新たなアプローチ2011

    • Author(s)
      里直行
    • Organizer
      第53回日本老年医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 認知症に対する新たなアプローチ2011

    • Author(s)
      里直行
    • Organizer
      第53回日本老年医学会学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認知症におけるアンチエイジングの役割と分子機序2011

    • Author(s)
      里直行
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 認知症におけるアンチエイジングの役割と分子機序2011

    • Author(s)
      里直行
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルツハイマー病と生活習慣病2011

    • Author(s)
      里直行
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] アルツハイマー病と生活習慣病2011

    • Author(s)
      里直行
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルツハイマー病と糖尿病の相互的病態修飾2011

    • Author(s)
      里直行、武田朱公、内尾-山田こずえ、樂木宏実、森下竜一
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 糖尿病がアルツハイマー病の後天的危険因子である機序2011

    • Author(s)
      里直行、武田朱公、内尾-山田こずえ、樂木宏実、森下竜一
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Dual Effects Of A Statin On Abeta Metabolism : Up-Regulation Of Degradation Of APP-CTF And Abeta Clearance2011

    • Author(s)
      Sato N, Shinohara M, Takeda S, Rakugi H, Morishita R.
    • Organizer
      The 10th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-03-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased Blood-Brain Barrier Vulnerability To Systemic Inflammation In Alzheimer Disease Mouse Model2011

    • Author(s)
      Takeda S, Sato N, Rakugi H, Morishita R.
    • Organizer
      The 10th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanistic Interaction Between Alzheimer Disease And Diabetes Mellitus : Analysis Of Novel Mouse Models Of Alzheimer Disease With Diabetes2011

    • Author(s)
      Takeda S, Sato N, Uchio-Yamada K, Rakugi H, Morishita R.
    • Organizer
      The 10th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alternation In Plasma Beta-Amyloid Levels After Glucose Loading Could Be A Novel Diagnostic Marker For Alzheimer Disease S.2011

    • Author(s)
      Takeda S, Sato N, Yu H, Moriguchi A, Uchio-Yamada K,Rakugi H, Morishita R.
    • Organizer
      The 10th International Conference on Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diabetes accelerates memory dysfunction via cerebrovascular dysfunction in an Alzheimer mouse model with diabetes2010

    • Author(s)
      武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖代謝が血中B・アミロイド蛋白(AB)量に与える影響の検討:アルツハイマー病の新規診断指標への応用2010

    • Author(s)
      武田朱公、里直行、内尾-山田こずえ、湯久浩、守口篤、楽木宏実、森下竜一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] アンジオテンシンII受容体拮抗薬はABによる脳血管反応性障害を抑制しアルツハイマー病モデルマウスの認知機能障害を改善する2010

    • Author(s)
      武田朱公、里直行、荻原俊男、狩野方伸、楽木宏実、森下竜一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model2010

    • Author(s)
      武田朱公、里直行、楽木宏実、森下竜一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] スタチンによるアルツハイマー病予防効果の機序の解明2010

    • Author(s)
      里直行、篠原充、島村宗尚、武田朱公、楽木宏実、森下竜一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 認知症病棟入院患者の周辺症状に対する抑肝散、非定型抗精神病薬、アンジオテンシン受容体拮抗薬の効果の検討2010

    • Author(s)
      里直行、武田朱公、湯久浩、守口篤、楽木宏実、森下竜一
    • Organizer
      第21回日本老年医学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖・エネルギー代謝が血中Abeta値に与える影響とその診断的応用2010

    • Author(s)
      武田朱公、里直行、湯久浩、守口篤、樂木宏実、森下竜一
    • Organizer
      第21回日本老年医学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規マイクロダイアライシス回収システムによる脳内ペプチドin vivo測定系の開発2010

    • Author(s)
      武田朱公、里直行、樂木宏実、森下竜一
    • Organizer
      第21回日本老年医学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model2010

    • Author(s)
      武田朱公、里直行、樂木宏実、森下竜一
    • Organizer
      第21回日本老年医学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 短期間の高カロリー食負荷はアルツハイマー病モデルマウスの認知機能障害を改善する2010

    • Author(s)
      武田朱公、里直行、樂木宏実、森下竜一
    • Organizer
      第21回日本老年医学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Possible Mutual Interaction Between Diabetes Mellitus and Alzheimer Disease : Generation of Novel Transgenic Mice Models of Alzheimer Disease With Diabetes2010

    • Author(s)
      Sato N, Takeda S, Rakugi H, Morishita R.
    • Organizer
      AHA Scientific Sessions 2010
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased brain vulnerability to systemic inflammation in Alzheimer disease transgenic mouse model2010

    • Author(s)
      Takeda S, Sato N, Rakugi H, Morishita R.
    • Organizer
      The 40th annual meeting of the Society for Neuroscience (Neuroscience 2010)
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病における血管性危険因子による病態修飾機序の解明2010

    • Author(s)
      武田朱公、里直行、荻原俊夫、楽木宏実、森下竜一
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Memory Impairment Associated with Recovery of Neurovascular Coupling2010

    • Author(s)
      Takeda S, Sato N, Kano M, Ogihara T, Rakugi H, Morishita R.
    • Organizer
      23rd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diabetes Accelerated Memory Dysfunction via Cerebrovascular Inflammation and Beta-Amyloid Deposition in Alzheimer Mouse Model : Generation of Novel Transgenic Mouse Models of Alzheimer Disease with Diabetes2010

    • Author(s)
      Takeda S, Sato N, Uchio-Yamada K, Rakugi H, Morishita R.
    • Organizer
      23rd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病と糖尿病の相互的病態修飾: Possible pathological interaction between diabetes mellitus and Alzheimer disease2010

    • Author(s)
      里直行、武田朱公、内尾-山田こずえ、楽木宏実、森下竜一
    • Organizer
      Neuro 2010 (第33回日本神経科学大会)
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病病態における血管性危険因子の役割:糖尿病合併アルツハイマー病モデルマウスの解析から:Role of vascular risk factors in the pathogenesis of Alzheimer disease : Analysis of novel mouse models of Alzheimer disease with diabete2010

    • Author(s)
      武田朱公、里直行、内尾-山田こずえ、篠原充、楽木宏実、森下竜一
    • Organizer
      Neuro 2010 (第33回日本神経科学大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diabetes mellitus exacerbated learning impairment via cerebrovascular inflammation and disturbance of brain insulin signaling in Alzheimer mouse models with diabetes2010

    • Author(s)
      Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Shinohara M, Rakugi H, Morishita R.
    • Organizer
      Alzheimer's Association International Conference on Alzheimer Disease 2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 全身糖代謝が血中AB濃度に与える影響の検討:糖負荷後血中ABの変動を利用した新たなアルツハイマー病診断指標の探索2010

    • Author(s)
      武田朱公、里直行、藤澤智巳、楽木宏実、森下竜一
    • Organizer
      第52回日本老年医学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病病態は末梢臓器でのインスリン抵抗性を増悪させることで糖尿病病態を増悪させる2010

    • Author(s)
      武田朱公、里直行、藤澤智巳、楽木宏実、森下竜一
    • Organizer
      第52回日本老年医学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病は脳血管障害と脳内インスリンシグナルの障害を介してアルツハイマー病脳内病態を修飾する2010

    • Author(s)
      武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、楽木宏実、森下竜一
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖負荷による血中ABの変動を利用した新たなアルツハイマー病診断指標の探索:全身糖代謝が血中AB濃度に与える影響の検討2010

    • Author(s)
      武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、楽木宏実、森下竜一
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanistic interaction between Alzheimer disease and diabetes2010

    • Author(s)
      Takeda S, Sato N, Rakugi H, Morishita R.
    • Organizer
      XXth World Congress of the International Society for Heart Research
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病とアルツハイマー病の相互的病態修飾機序の解明:糖尿病合併アルツハイマー病モデルマウスの作成とその病態解析2010

    • Author(s)
      武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] HMG還元酵素阻害薬フルバスタチンのAB代謝作用の解析2010

    • Author(s)
      篠原充、里直行、武田朱公、野間基子、森下竜一
    • Organizer
      第29回日本認知症学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病合併アルツハイマー病モデルマウスにおける脳血管病態と脳内インスリンシグナルの変化2010

    • Author(s)
      武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
    • Organizer
      第29回日本認知症学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fluvastatin(an HMG-CoA reductase inhibitor) reduces Aβlevels in brain by upregulating2009

    • Author(s)
      M. Shinohara, N. Sato, H. Kurinami, D. Takeuchi, S. Takeda, M. Noma, H. Rakugi, R. Morishita
    • Organizer
      APP-CTFs degradation and Aβclearance Nuroscience2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Fluvastatin (an HMG-CoA reductase inhibitor) reduces Abeta levels in brain by upregulating APP-CTFs degradation and Abeta clearance2009

    • Author(s)
      M.Shinohara, N.Sato, H.Kurinami, D.Takeuchi, S.Takeda, M.Noma, H.Rakugi, R.Morishita
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Possible mutual interaction between diabetes mellitus and Alzheimer' s disease : Generation of novel transgenic mice models of Alzheimer' s disease with diabetic conditions2009

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita
    • Organizer
      ICAD(International Conference on Alzheimer' s Disease) 2009
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2009-07-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible mutual interaction between diabetes mellitus and Alzheimer's disease : Generation of novel transgenic mice models of Alzheimer's disease with diabetic conditions2009

    • Author(s)
      Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
    • Organizer
      ICAD (International Conference on Alzheimer's Disease) 2009
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2009-07-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] アルツハイマー病根本治療を目指したフルバスタチンの新規抗Aβ作用の解明2009

    • Author(s)
      篠原充、里直行、栗波仁美、竹内大亮、武田朱公、野間基子、楽木宏美、森下竜一
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 血糖状態及び血中インスリン値は血中Aβ量を修飾する:血中Aβ値のアルツハイマー病バイオマーカーとしての最適化条件の検討2009

    • Author(s)
      武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、栗波仁美、竹内大亮、楽木宏美、森下竜一
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 血糖状態及び血中インスリン値は血中Aβ量を修飾する : 血中Aβ値のアルツハイマー病バイオマーカーとしての最適化条件の検討2009

    • Author(s)
      武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、栗波仁美、竹内大亮、楽木宏美、森下竜一
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] アルツハイマー病と糖尿病の相互的病態修飾機序の解明:新規病態合併モデル動物の作成とその解析2009

    • Author(s)
      武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、栗波仁美、竹内大亮、楽木宏美、森下竜一
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-18
    • Related Report
      2011 Final Research Report
  • [Presentation] アルツハイマー病と糖尿病の相互的病態修飾機序の解明 : 新規病態合併モデル動物の作成とその解析2009

    • Author(s)
      武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、栗波仁美、竹内大亮、篠原充、楽木宏美、森下竜一
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] アルツハイマー病根本治療を目指したフルバスタチンの新規抗Aβ作用の解明2009

    • Author(s)
      篠原充、里直行、栗波仁美、竹内大亮、武田朱公、野間基子、楽木宏美、森下竜一
    • Organizer
      アルツハイマー病根本治療を目指したフルバスタチンの新規抗Aβ作用の解明
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c_4.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c_4.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 透析プローブ2010

    • Inventor(s)
      武田朱公、里直行、森下竜一、西野博仁、生村和子
    • Industrial Property Rights Holder
      大阪大学、株式会社エイコム
    • Acquisition Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 透析プローブ2010

    • Inventor(s)
      武田朱公、里直行、森下竜一、西野博仁、生村和子
    • Industrial Property Rights Holder
      大阪大学、株式会社エイコム
    • Acquisition Date
      2010-11-19
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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