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QT延長症候群患者における網羅的単一塩基多型分析

Research Project

Project/Area Number 21659199
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

堀江 稔  滋賀医科大学, 医学部, 教授 (90183938)

Co-Investigator(Kenkyū-buntansha) 上島 弘嗣  滋賀医科大学, 医学部, 特任教授 (70144483)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2009: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords分子心臓病態 / 分子心臓病態学
Research Abstract

QT延長症候群(LQTS)は、著しいQT時間の延長とtorsade de pointesを起こす家族性LQTSは若年者に見られ心臓突然死を起こす。心筋の興奮・伝導・収縮を司る蛋白分子であるイオン・チャネルやその調節蛋白をコードする遺伝子の変異や多型(とくに単一塩基多型=Single Nucleotide Polymorphism以下SNP)が関与している。これらの遺伝的異常のため心筋チャネル蛋白の働きが変化し発症するイオン・チャネル病である。また、従来、SNPは数10から数1000塩基にひとつの頻度で存在し個人の特性を決定するとされたが、最近、病気の発症とも関連する機能的なSNPも知られている。我々は2009年にLQTS関連遺伝子のKCNE1のSNPであるD85Nが、本症の発症に関与することを報告している。このような多様な遺伝的背景を有し、多くは常染色体優性遺伝をするが、実際の臨床現場に遺伝的背景をフィードバックすると、遺伝子変異のキャリアにもかかわらず、LQTSの病像をまったく示さない症例に多く遭遇する。このようなSNP解析モデルとして遺伝子変異が同定されている子供が典型的なQT延長症候群を発症しているにもかかわらず、キャリアの親が35才まで無症候である症例を選択し網羅的なSNP解析を行った。当初、32個の候補SNPについて2人のデータを比較検討することにより、本症の発症を促進する方向に働くSNPと予防的に働くSNPを検索した。これらの研究は、フランス・パリ大学、イタリア・Pavia大学、オランダ・Amsterdam大学の研究室との共同研究のかたちで行った。興味深いことに我々の報告したKCNE1 D85Nがやはり親子モデルでも発症誘因に有意に働くことが判明した。

Report

(2 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (131 results)

All 2011 2010 2009 Other

All Journal Article (73 results) (of which Peer Reviewed: 65 results) Presentation (48 results) Book (8 results) Remarks (2 results)

  • [Journal Article] Novel KCNE5 variants are associated with Brugada syndrome and idiopathic ventricular fibrillation.2011

    • Author(s)
      Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Hancox JC, Matsuura H, Horie M
    • Journal Title

      Circulation Arrhythmia and Electrophysiology

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of Andersen-Tawil syndrome.2011

    • Author(s)
      Doi T, Makiyama T, Morimoto T, Haruna Y, Tsuji K, Ohno S, Akao M, Takahashi Y, Kimura T, Horie M
    • Journal Title

      Circulation : Cardiovascular Genetics

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Remission of abnormal conduction and repolarization in the right ventricle after chemotherapy in patients with anterior mediastinal tumor.2011

    • Author(s)
      Miyamoto A, Hayashi H, Ito M, Horie M
    • Journal Title

      J Cardiovasc Electrophysiol.

      Volume: 22 Pages: 350-350

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk determinants in individuals with a spontaneous type 1 Brugada ECG.2011

    • Author(s)
      Miyamoto A, Hayashi H, Makiyama T, Yoshino T, Mizusawa Y, Sugimoto Y, Ito M, Xue JQ, Murakami Y, Horie M.
    • Journal Title

      Circulation Journal

      Volume: 75 Pages: 844-851

    • NAID

      10028103115

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ペースメーカ植込み同胞例に認められたあらたなLamin A/C変異A novel lamin A/C gene mutation in siblings treated with cardiac pacemaker2011

    • Author(s)
      佐野幹、渡邉英一、牧山武、内山達司、祖父江嘉洋、奥田健太郎、山本真由美、堀江稔、尾崎行男
    • Journal Title

      心電図

      Volume: 31 Pages: 18-24

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QTc prolongation and antipsychotic medication in 1017 patients with schizophrenia.2010

    • Author(s)
      Ozeki Y, Fujii K, Kuromoto N, Yamada N, Okawa M, Aoki T, Takahashi J, Narita M, Ishida N, Saito O, Horie M, Kunugi H.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 34 Pages: 401-405

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders.2010

    • Author(s)
      Wu J, Shimizu W, Ding W-G, Ohno S, Toyada F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee J, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M.
    • Journal Title

      Heart Rhythm

      Volume: 7 Pages: 199-205

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and genetic background of congenital long QT syndrome diagnosed in fetal, neonatal and infantile life. A nation-wide questionnaire survey in Japan.2010

    • Author(s)
      Horigome H, Nagashima M, Sumitomo N, Yoshinaga M, Ushinohama H, Iwamoto M, Shiono J, Ichihashi K, Hasegawa S, Yoshikawa T, Matsunaga T, Goto H, Waki K, Arima M, Takasugi H, Tanaka Y, Miura M, Ogawa K, Suzuki H, Yamagishi H, Ikoma M, Suda K, Takagi J, Sato J, Shimizu H, Saiki H, Hoshiai M, Ichida F, Takeda S, Takigiku K, Inamura N, Kajino H, Murakami T, Shimizu W, Horie M.
    • Journal Title

      Circ.Arrhythm Electrophysiol.

      Volume: 3 Pages: 10-17

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P-wave and the development of atrial fibrillation.2010

    • Author(s)
      Ishida K, Hayashi H, Miyamoto A, Sugimoto Y, Ito M, Murakami Y, Horie M.
    • Journal Title

      Heart Rhythm

      Volume: 7 Pages: 289-294

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of early repolarization in short QT syndrome.2010

    • Author(s)
      Watanabe H, Makiyama T, Koyama T, Kannankeril PJ, Seto S, Okamura K, Oda H, Itoh H, Okada M, Tanabe N, Yagihara N, Kamakura S, Horie M, Aizawa Y, Shimizu W.
    • Journal Title

      Heart Rhythm

      Volume: 7 Pages: 674-652

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the rapidly activating delayed rectifier potassium current, IKr, in HL-1 mouse atrial myocytes.2010

    • Author(s)
      Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H.
    • Journal Title

      Journal of Membrane Biology

      Volume: 235 Pages: 73-87

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A family of hereditary long QT syndrome caused by Q738X HERG mutation.2010

    • Author(s)
      Yasuda S, Hiramatsu S, Odashiro K, Maruyama T, Tsuji K, Horie M.
    • Journal Title

      Int J Cardiol.

      Volume: 144 Pages: 69-72

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na(v)1.5 in a neonate with fatal long QT syndrome.2010

    • Author(s)
      Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane Y, Makiyama T, Horie M, Hara T.Int J Cardiol.
    • Journal Title

      Int J Cardiol.

      Volume: 145 Pages: 61-64

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bi-directional ventricular tachycardia revised.2010

    • Author(s)
      Horie M.
    • Journal Title

      Journal of Arrhythmia

      Volume: 26 Pages: 3-4

    • NAID

      10027081138

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long QT syndrome with compound mutations is associated with a more severe phenotype : A Japanese multicenter study.2010

    • Author(s)
      Itoh H, Shimizu W, Hayashi K, Yamagata K, Sakaguchi T, Ohno S, T Makiyama, Akao M, Ai T, Noda T, Miyazaki A, Miyamoto Y, Yamagishi M, Kamakura S, Horie M.
    • Journal Title

      Heart Rythm

      Volume: 7 Pages: 1411-1418

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to ongenital long QT syndrome.2010

    • Author(s)
      Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Akashi M, Kawamura M, Matsuura H, Horie M.
    • Journal Title

      Circulation Journal

      Volume: 17 Pages: 2535-2571

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart rate-dependent variability of cardiac events in type 2 congenital long-QT syndrome.2010

    • Author(s)
      Nagaoka I, Shimizu W, Mizusawa Y, Sakaguchi T, Itoh H, Ohno S, Makiyama T, Yamagata K, Makimoto H, Miyamoto Y, Kamakura S, Horie M.
    • Journal Title

      Europace

      Volume: 12 Pages: 1623-1629

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and QT interval of early repolarization in a hospital-based population.2010

    • Author(s)
      Hayashi H, Miyamoto A, Ishida K, Yoshino T, Sugimoto Y, Ito M, Horie M.
    • Journal Title

      Journal of Arrhythmia

      Volume: 26 Pages: 127-133

    • NAID

      10027574234

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability.2010

    • Author(s)
      Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Shirayoshi Y, Hiraoka M, Hisatome I., Circ Res
    • Journal Title

      Circ Res.

      Volume: 108 Pages: 458-468

    • NAID

      130002130408

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子異常と不整脈2010

    • Author(s)
      伊藤英樹、堀江稔
    • Journal Title

      臨床と研究

      Volume: 87 Pages: 98-101

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QTが長ければQT延長症候群か?2010

    • Author(s)
      伊藤英樹、堀江稔
    • Journal Title

      medicina

      Volume: 47 Pages: 66-68

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人の心房細動における治療戦略の最新状況2010

    • Author(s)
      堀江稔
    • Journal Title

      Trans BEAT

      Volume: 7 Pages: 12-14

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] デスモゾーム病としての不整脈源性右室心筋症-デスモゾーム分子遺伝子異常2010

    • Author(s)
      堀江稔
    • Journal Title

      医学のあゆみ

      Volume: 232 Pages: 588-592

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運動中の心臓性突然死:成人の不整脈2010

    • Author(s)
      堀江稔
    • Journal Title

      心電図

      Volume: 30-S2 Pages: 13-24

    • NAID

      10027705016

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 先天性QT延長症候群の遺伝子診断-複数異変症例の検討-2010

    • Author(s)
      伊藤英樹、清水渉、林研至、山形研一郎、坂口知子、大野聖子、牧山武、赤尾昌治、藍智彦、野田崇、宮崎文、宮本恵宏、山岸正和、鎌倉史郎、堀江稔
    • Journal Title

      心電図

      Volume: 30 Pages: 195-199

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性ペースメーカー植え込み症例における遺伝的背景の検討-心臓Na+チャネル病、Lamin A/C遺伝子関連心筋症-2010

    • Author(s)
      牧山武、静田聡、赤尾昌治、木村剛、堀江稔
    • Journal Title

      心電図

      Volume: 30 Pages: 200-208

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カテコラミン誘発性多形性心室頻拍を疑う患者における遺伝子変異の検討-心筋リアノジン受容体について-Mutations of the cardiac ryanodine recepter gene in Catecholaminergic Polymorphic Ventricular Tachycardia2010

    • Author(s)
      川村美朋子、長岡伊織、道智賢市、西尾由貴子、伊藤英樹、木村紘美、宮本証、水澤有香、地藤優子、石田勝也、伊藤誠、牧山武、大野聖子、住友直方、小山耕太郎、堀江稔
    • Journal Title

      心電図

      Volume: 30 Pages: 298-305

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性不整脈の診断と治療におけるiPS細胞利用の可能性2010

    • Author(s)
      堀江稔
    • Journal Title

      最新医学 The Medical Frontline

      Volume: 65 Pages: 139-145

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高血圧と不整脈:高血圧治療によって不整脈発生の予防は可能か?2010

    • Author(s)
      堀江稔
    • Journal Title

      Life Style Medicine

      Volume: 4 Pages: 28-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性不整脈の診断と治療2010

    • Author(s)
      堀江稔
    • Journal Title

      臨床医のための循環器診療13

      Volume: 13 Pages: 29-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of early repolarization in short QT syndrome2010

    • Author(s)
      Watanabe H, Makiyama T, Koyama T, Kannankeril PJ, Seto S, Okamura K, Oda H, Itoh H, Okada M, Tanabe N, Yagihara N, Kamakura S, Horie M, Aizawa Y, Shimizu W.
    • Journal Title

      Heart Rhythm 7

      Pages: 647-652

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P-wave and the development of atrial fibrillation2010

    • Author(s)
      Ishida K, Hayashi H, Miyamoto A, Sugimoto Y, Ito M, Murakami Y, Horie M
    • Journal Title

      Heart Rhythm 7

      Pages: 289-294

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QTc prolongation and antipsychotic medication in 1017 patients with schizophrenia2010

    • Author(s)
      Ozeki Y, Fujii K, Kuromoto N, Yamada N, Okawa M, Aoki T, Takahashi J, Narita M, Ishida N, Saito O, Horie M, Kunugi H
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 34

      Pages: 401-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and genetic background of congenital long QT syndrome diagnosed in fetal, neonatal and infantile life. A nation-wide questionnaire survey in Japan2010

    • Author(s)
      Horigome H, Nagashima M, Sumitomo N, Yoshinaga M, Ushinohama H, Iwamoto M, Shiono J, Ichihashi K, Hasegawa S, Yoshikawa T, Matsunaga T, Goto H, Waki K, Arima M, Takasugi H, Tanaka Y, Miura M, Ogawa K, Suzuki H, Yamagishi H, Ikoma M, Suda K, Takagi J, Sato J, Shimizu H, Saiki H, Hoshiai M, Ichida F, Takeda S, Takigiku K, Inamura N, Kajino H, Murakami T, Shimizu W, Horie M
    • Journal Title

      Circ Arrhythm Electrophysiol 3

      Pages: 10-17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] デスモゾーム病としての不整脈源性右室心筋症-デスモゾーム分子遺伝子異常2010

    • Author(s)
      堀江稔
    • Journal Title

      医学のあゆみ 223

      Pages: 588-592

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子異常と不整脈2010

    • Author(s)
      伊藤英樹, 堀江稔
    • Journal Title

      臨床と研究 87

      Pages: 98-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QTが長ければQT延長症候群か?2010

    • Author(s)
      伊藤英樹, 堀江稔
    • Journal Title

      medicina 47

      Pages: 66-68

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KCNE2 modulation of KV4.3 current and its potential role in fatal rhythm disorders2010

    • Author(s)
      Wu J, Shimizu W, Ding W-G, Ohno S, Toyada F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee J, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M.
    • Journal Title

      Heart Rhythm 7

      Pages: 199-205

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      堀江稔
    • Journal Title

      今日の治療方針 : 心房細動(医学書院)

      Pages: 300-302

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      堀江稔
    • Journal Title

      Annual Review 循環器 : ARB/ACE-1による心房細動抑止効果(中外医学)

      Pages: 182-188

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel2009

    • Author(s)
      Ikrar T, Hanawa H, Watanabe H, Aizawa Y, Ramadan MM, Chinushi M, Horie M, Aizawa Y
    • Journal Title

      BBRC 378

      Pages: 589-594

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenergic regulation of the rapid component of delayed rectifier K^<+> current : Implications for arrhythmogenesis in LQT2 patients2009

    • Author(s)
      Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M
    • Journal Title

      Heart Rhythm 6

      Pages: 1038-1046

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aortopulmonary artery dissection2009

    • Author(s)
      Itoh H, Yamamoto T, Sugihara H, Saotome T, Eguchi Y, Asai T, Horie M
    • Journal Title

      JACC 54

      Pages: 1990-1990

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin-1 as a predictor of atrial fibrillation recurrence after pulmonary vein isolation2009

    • Author(s)
      Nakazawa Y, Ashihara T, Tsutamoto T, Ito M, Horie M
    • Journal Title

      Heart Rhythm 6

      Pages: 725-730

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal treatment strategy for patients with paroxysmal atrial fibrillation : J-RHYTHM Study2009

    • Author(s)
      Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H, J-RHYTHM Investigators
    • Journal Title

      Circ J 73

      Pages: 242-248

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of IKs current in guinea pig atrium2009

    • Author(s)
      Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura M, Horie M
    • Journal Title

      Pflugers Arch. 458

      Pages: 837-849

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome2009

    • Author(s)
      Nishio Y, Makiyama T, Itoh H, Sakaguchi T, Ohno S, Gong Y-Z, Yamamoto S, Ozawa T, Ding W-G, Toyoda F, Kawamura M, Akao M, Matsuura H, Kita T, Horie M
    • Journal Title

      JACC 54

      Pages: 812-819

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)2009

    • Author(s)
      Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kanda H, Kita Y, Kadowaki T, Tsujita Y, Turin T C, Horie M, Miki T, Ueshima H.
    • Journal Title

      Int J Cardiol 136

      Pages: 354-355

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of atrial fibrillation in the general population of Japan : An analysis based on periodic health examination2009

    • Author(s)
      Inoue H, Fujiki A, Origasa H, Ogawa S, Okumura K, Kubota I, Aizawa Y, Yamashita T, Atarashi H, Horie M, Ohe T, Doi Y, Shimizu A, Chishaki A, Saikawa T, Yano K, Kitabatake A, Mitamura H, Kodama I, Kamakura S.
    • Journal Title

      Int J Cardiol 137

      Pages: 102-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholesteryl ester transfer protein, coronary calcium and intima-media thickness of the carotid artery in middle-aged Japanese men2009

    • Author(s)
      Okamura T, Sekikawa A, Kadowaki T, El-Saed A, Abbott DR, Curb JD, Edmundowicz D, Nakamura Y, Murata K, Kashiwagi A, Kim ST, Evans RW, Zmuda JM, Maegawa H, Hozawa A, Mitsunami K, Nisio Y, Iva MG, Horie M, Miyamastu N, Murakami Y, Kuller LH, Ueshima H.
    • Journal Title

      Am J Cardiol. 104

      Pages: 818-822

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term prognosis of probands with brugada-pattern ST-Elevation in leads V1-V32009

    • Author(s)
      Kamakura S, Ohe T, Nakazawa K, Aizawa Y, Shimizu A, Horie M, Ogawa S, Okumura K, Tsuchihashi K, Sugi K, Makita N, Hagiwara N, Inoue H, Atarashi H, Aihara N, Shimizu W, Kurita T, Suyama K, Noda T, Satomi K, Okamura H, Tomoike H.
    • Journal Title

      Circulation Arrhythmia & EP

      Pages: 495-503

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latent genetic backgrounds and molecular pathogenesis in drug-induced long QT syndrome2009

    • Author(s)
      Itoh H, Sakaguchi T, Ding WS, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M
    • Journal Title

      Circulation Arrhythmia & EP 2

      Pages: 511-523

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory actions of LY294002, a phosphatidylinositol 3-kinase inhibitor, on the human Kv1.5 channel2009

    • Author(s)
      Wu J, Ding WG, Matsuura H, Tsuji K, Zang WJ, Horie M.
    • Journal Title

      Brit J Pharm 56

      Pages: 377-387

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel KCNE3 mutations interact with KCNQ1 and cause long QT syndrome2009

    • Author(s)
      Ohno S, Toyoda F, Zankov D, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Matsuura H, Shimizu W, Miyamoto Y, Kamakura S, Kita T, Horie M.
    • Journal Title

      Hum Muta 30

      Pages: 557-563

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel KCNH2 mutation as a modifier for short QT interval2009

    • Author(s)
      Itoh H, Sakaguchi T, Ashihara T, Ding G W, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ito M, Matsuura H, Horie M.
    • Journal Title

      Int J Cardiol. 137

      Pages: 83-85

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性QT延長症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      ICUとCCU 33

      Pages: 19-24

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TOP-不整脈研究の流れ2009

    • Author(s)
      堀江稔
    • Journal Title

      BIO Clinica 24

      Pages: 405-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Romano-Ward 症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      小児科診療 72

      Pages: 221-221

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Jervell lange Nielsen2009

    • Author(s)
      堀江稔
    • Journal Title

      小児科診療 72

      Pages: 215-215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Andersen 症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      Current Therapy 27

      Pages: 458-459

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アップストリーム治療2009

    • Author(s)
      堀江稔
    • Journal Title

      診断と治療 97

      Pages: 1022-1027

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性QT延長症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      循環器科 65

      Pages: 546-550

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不整脈研究の流れ2009

    • Author(s)
      堀江稔
    • Journal Title

      BIO Clinica 310

      Pages: 405-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical mapping による spiral wave の解析2009

    • Author(s)
      本荘晴明, 山崎正俊, 石黒有子, 神谷香一郎, 佐久間一郎, 芦原貴司, 堀江稔, 児玉逸雄
    • Journal Title

      心電図 29

      Pages: 231-235

    • NAID

      10026293138

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      小児科 50

      Pages: 1083-1087

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性不整脈2009

    • Author(s)
      堀江稔
    • Journal Title

      Heart View 13

      Pages: 47-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長の潜在的危険性の予知-遺伝子多型 : KCNE1-D85N-2009

    • Author(s)
      西尾由貴子, 堀江稔
    • Journal Title

      循環器専門医 17

      Pages: 237-242

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      循環器疾患最新の治療2010-2011 : 脚ブロック(南江堂)

      Pages: 287-290

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      重篤副作用疾患別対応マニュアル : 心室頻拍(厚生労働省)

      Pages: 1-20

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      最新医学別冊新しい診断と治療のABC15 循環器2 心房細動 (改訂第2版) : 心房リモデリング(最新医学社)

      Pages: 59-66

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      遺伝性不整脈 4. QT延長症候群(最新医学社)

      Pages: 105-112

    • Related Report
      2009 Annual Research Report
  • [Journal Article] A family of hereditary long QT syndrome caused by Q738X HERG mutation

    • Author(s)
      Yasuda S, Hiramatsu S, Odashiro K, Maruyama T, Tsuji K, Horie M.
    • Journal Title

      Int J Cardiol. (in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na (v) 1.5 in a neonate with fatal long QT syndrome

    • Author(s)
      Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane Y, Makiyama T, Hoire M, Hara T.
    • Journal Title

      Int J Cardiol. (in press)

    • Related Report
      2009 Annual Research Report
  • [Presentation] 特発性心房細動(ブルガダ・J派症候群)の診断と治療2010

    • Author(s)
      堀江稔
    • Organizer
      新潟/群馬循環器カンファレンス
    • Place of Presentation
      群馬(招待講演)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] イオンチャネル病としてのQT延長症候群-多様な発症メカニズム-2010

    • Author(s)
      堀江稔
    • Organizer
      第25回犬山不整脈カンファランス
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] RYR2変異が同定され、フレカイニドが著効したカテコラミン誘発性多形性心室頻拍(CPVT)の一成人例2010

    • Author(s)
      川村美朋子、道智賢一、松井圭司、松本祐一、長岡伊織、伊藤誠、芦原貴司、伊藤英樹、八尾武憲、坂口知子、中澤優子、辻啓子、城日加里、杉本喜久、小澤友哉、木村紘美、宮本証、地藤優子、水澤有香、堀江稔
    • Organizer
      第30回日本ホルター・ノンインベイシブ心電学研究会
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Inherited Ventricular Arrhythmic Disorders in Asia : What's New and What's Different from US and Europe?2010

    • Author(s)
      Makiyama T, Ohno S, Wu J, Kimura T, Horie M
    • Organizer
      Heart Rhythm 2010 Scientific Sessions
    • Place of Presentation
      Denver U.S.A
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of fibroblasts in the mechanism of complex fractionated atrial electrograms during chronic atrial fibrillation.2010

    • Author(s)
      Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Itch H, Sugimoto Y, Ito M, Horie M
    • Organizer
      Heart Rhythm 2010 Scientific Sessions
    • Place of Presentation
      Denver U.S.A
    • Related Report
      2010 Annual Research Report
  • [Presentation] P pulmonale and atrial fibrillation.2010

    • Author(s)
      Miyamoto A, Hayashi H, Ishida K, Yoshino T, Sugimoto Y, Ito M, Horie M
    • Organizer
      ISHR2010
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adenosine attenuates the appearance of myocardial ischemia-induced J wave.2010

    • Author(s)
      Yoshino T, Hayashi H, Nakae I, Miyamoto A, Ishida K, Matsumoto T, Horie M.
    • Organizer
      ISHR2010
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] J wave and intrathoracic tumor.2010

    • Author(s)
      Hayashi H, Miyamoto A, Ishida K, Yoshino T, Sugimoto Y, Ito M, Horie M.
    • Organizer
      ISHR2010
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Long QT syndrome with compound mutation is associated with a severer phenotype : a Japanese multicenter study.2010

    • Author(s)
      Itoh H, Shimizu W, Hayashi K, Yamagata K, Sakaguchi T, Makiyama T, Miyamoto Y, Yamagishi Y, Kamakura S, Horie M.
    • Organizer
      ESC Congress 2010
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先天性QT延長症候群の遺伝子解析とその臨床的有用性-日本国内多施設登録からの検討-2010

    • Author(s)
      牧元久樹、堀江稔、小川聡、相澤義房、大江透、草野研吾、山岸正和、蒔田直昌、田中敏博、牧山武、吉永正夫、萩原誠久、鎌倉史郎、宮本恵宏、清水渉
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非選択性α<sub>1</sub>-βアドレナリン受容体遮断薬(カルベジロール)は2型QT延長症候群の心イベントを抑制する2010

    • Author(s)
      木村紘美、伊藤英樹、水澤有香、宮本証、岡優子、川村美朋子、西尾由貴子、坂口知子、丁維光、牧山武、伊藤誠、松浦博、堀江稔
    • Organizer
      第27回日本心電学会学術集会
    • Place of Presentation
      大分
    • Related Report
      2010 Annual Research Report
  • [Presentation] Electrical Cardiomyopathy : Ion Channel Diseases.2010

    • Author(s)
      Horie M.
    • Organizer
      CJCF2010
    • Place of Presentation
      Beijing, China(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Influence of pulmonary vein isolation on heart rate : A clinical study using event-ECG monitors.2010

    • Author(s)
      Nakazawa Y, Ashihara T, Miyamoto A, Ozawa T, Itch H, Sugimoto Y, Ito M, Horie M.
    • Organizer
      APHRS2010/APAFS2010
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of fibroblasts in the mechanisms of complex fractionated atrial electrograms and catheter ablation during chronic atrial fibrillation.2010

    • Author(s)
      Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Itoh H, Ito M, Horie M.
    • Organizer
      APHRS2010/APAFS2010
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic Background of Japanese Patients with Long QT Syndrome.2010

    • Author(s)
      Horie M
    • Organizer
      APHRS2010/APAFS2010
    • Place of Presentation
      Jeju Island, Korea(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Latent genetic backgrounds and molecular pathogenesis in acquired long QT syndrome with distinct arrhythmic triggers.2010

    • Author(s)
      Itoh H, Oka Y, Ding WG, Sakaguchi T, Kimura H, Mizusawa Y, Miyamoto A, Wu J, Ohno S, Makiyama T, Ito M, Matsuura H, Horie M.
    • Organizer
      AHA Scientific Sessions 2010
    • Place of Presentation
      Chicago Illinois U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Carvedilol, an α1- and Non-selective β-adrenoceptor Blocker, for Prevention of Cardiac Events in Patients with Type 2 Long QT Syndrome2010

    • Author(s)
      Kimura H, Itoh H, Mizusawa Y, Miyamoto A, Oka Y, Kawamura M, Nishio Y, Sakaguchi T, Makiyama T, Ito M, Horie M.
    • Organizer
      AHA Scientific Sessions 2010.
    • Place of Presentation
      Chicago Illinois U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Presentation] 薬物誘発性QT延長症候群の基礎と臨床2010

    • Author(s)
      堀江稔
    • Organizer
      第31回日本臨床薬理学会年会
    • Place of Presentation
      京都(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ICD植え込み後にVF onset が明らかとなった心肺蘇生後の一例2009

    • Author(s)
      八尾武憲, 宮本証, 中澤優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      ICD公開研究会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心房細動を巡る最近の話題2009

    • Author(s)
      堀江稔
    • Organizer
      第2回東西循環器懇話会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多量の心嚢水を認めた好酸球性心筋炎の1例2009

    • Author(s)
      吉井理一郎, 高山幸一郎, 山下寛人, 中澤優子, 伊藤英樹, 高島弘行, 伊藤誠, 堀江稔
    • Organizer
      第189回日本内科学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多量の心嚢水貯留を認めた好酸球性心筋炎の一例2009

    • Author(s)
      吉井理一郎, 伊藤英樹, 高山幸一郎, 山下寛人, 八尾武憲, 谷口晋, 中澤優子, 芦原貴司, 山本孝, 高島弘行, 藤井応理, 中江一郎, 林秀樹, 杉本喜久, 松本鉄也, 蔦本尚慶, 伊藤誠, 堀江稔
    • Organizer
      第67回 滋賀県循環器疾患研究会
    • Place of Presentation
      滋賀
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポストゲノム時代の不整脈診療を考える2009

    • Author(s)
      堀江稔
    • Organizer
      第29回福島心疾患治療談話会
    • Place of Presentation
      福島
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺静脈隔離術後の心房細動再発予測におけるエンドセリン1の有用性2009

    • Author(s)
      中澤優子, 芦原貴司, 八尾武憲, 伊藤英樹, 城日加里, 杉本喜久, 蔦本尚慶, 伊藤誠, 堀江稔, 八木崇文
    • Organizer
      第7回滋賀呼吸循環器フォーラム
    • Place of Presentation
      大津
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心臓突然死を巡る不整脈診療の話題2009

    • Author(s)
      堀江稔
    • Organizer
      第6回西海不整脈フォーラム
    • Place of Presentation
      長崎
    • Year and Date
      2009-08-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 循環器診療におけるARB治療を考える-Beyond Blood Pressure-2009

    • Author(s)
      堀江稔
    • Organizer
      アバプロ錠1周年記念講演会
    • Place of Presentation
      滋賀
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 劇症型心筋炎の2例~診断のポイント~2009

    • Author(s)
      酒井宏, 寺村真範, 高山智行, 環愼二, 岡林旅人, 川嶋剛史, 山本孝, 高島弘行, 堀江稔
    • Organizer
      第24回滋賀心不全研究会
    • Place of Presentation
      滋賀
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病でみられる不整脈の特徴とその管理2009

    • Author(s)
      堀江稔
    • Organizer
      第52回 日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 下肢機能性血流障害を伴う2型糖尿病患者の冠動脈造影像2009

    • Author(s)
      大村寧, 鈴木英司, 坂口正芳, 貴志明生, 吉村達, 高島弘行, 卯木智, 西尾善彦, 前川聡, 堀江稔, 武田純, 柏木厚典
    • Organizer
      第52回 日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Overlap syndromes in inherited arrhythmia disorders2009

    • Author(s)
      堀江稔
    • Organizer
      ISHNE 2009
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structure-function relationships of K channels. 2nd Asia pacific heart rhythm society science session2009

    • Author(s)
      堀江稔
    • Organizer
      APHRS 2009
    • Place of Presentation
      Beijin, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical Phenotype and Prognosis of Probands With Brugada Syndrome in Relation to SCN5A Mutation.-Japanese Brugada Syndrome Multicenter Registry2009

    • Author(s)
      Yamagata K, Horie M, Ogawa S, Aizawa Y, Kusano K F, Ohe T, Yamagishi M, Makita N, Tanaka T, Makiyama T, Akao M, Hagiwara N, Kishi Y, Yamada Y, Okamura H, Noda T, Satomi K, Suyama K, Aihara N, Miyamoto Y, Kamakura S, Shimizu W
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel KCNE5 Mutations Are Associated With Brugada Syndrome and Idiopathic Ventricular Fibrillation2009

    • Author(s)
      Ohno S, Zankov DP, Ding W-G, Makiyama T, Hattori T, Doi T, Shizuta S, Kimura T, Matsuura H, Horie M
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association of Early Repolarization With Arrhythmic Events in Short QT Syndrome2009

    • Author(s)
      Watanabe H, Makiyama T, Prince JK, Seto S, Okamura S, Oda H, Ito H, Horie M, Aizawa Y, Shimizu W
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] A Novel Gain-of-function KCNJ2 Mutation Associated With Short QT Syndrome Impairs Inward Rectification of Kir 2.1 Currents2009

    • Author(s)
      Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Nishio Y, Itoh H, Yokode M, Kimura T, Horie M
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺静脈隔離術後の心房細動再発検出における携帯型心電計の有用性2009

    • Author(s)
      中澤優子, 芦原貴司, 八尾武憲, 城日加里, 伊藤英樹, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第29回日本ホルター・ノンインベイシブ心電学研究会 (JASHNE 2009)
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 早期再分極の解析2009

    • Author(s)
      林秀樹, 石田勝也, 宮本証, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多種類の上室頻拍を合併した心臓手術後の一例2009

    • Author(s)
      城日加里, 八尾武憲, 山科聡, 中澤優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔, 八木崇文
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 先天性QT延長症候群の遺伝子診断-複数変異例の検討-2009

    • Author(s)
      伊藤英樹, 清水渉, 林研至, 山形研一郎, 坂口知子, 大野聖子, 牧山武, 赤尾昌治, 藍智彦, 野田崇, 宮崎彩, 宮本恵宏, 山岸正和, 鎌倉史郎, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] At-Home AED : ICD植込みが困難な患者に対する代替法としてのAED利用について2009

    • Author(s)
      八尾武憲, 城日加里, 中澤優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] V1誘導は Brugada 症候群の risk stratification となるか? : spontaneous coved-type ST-segment elevation を呈した症例の検討2009

    • Author(s)
      宮本証, 林秀樹, 石田勝也, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 家族性進行性心臓伝導障害に同定された connexin 40遺伝子GJA5異変の機能異常2009

    • Author(s)
      蒔田直昌, 住友直方, 関明子, 萩原誠久, 渡部裕, 福原茂明, 望月直樹, 牧山武, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] SCN5A遺伝子異常を伴った洞不全症候群合併 Brugada 症候群の一例2009

    • Author(s)
      早野譲, 静田聡, 牧山武, 中尾哲史, 根津知行, 山口孝之, 塚本学, 土井孝治, 西山慶, 赤尾昌治, 木村剛, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 家族性ペースメーカー植込み症例における遺伝的背景の検討-心臓NA+チャネル病、lamin A/C関連心筋症-2009

    • Author(s)
      牧山武, 横出正之, 赤尾昌治, 静田聡, 土井孝浩, 池田智之, 大野聖子, 服部哲久, 西尾由貴子, 木村剛, 北徹, 宮本証, 伊藤英樹, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Overlap between LQT3 and syndrome : Clinical features in a common mutation and underlying biophysical mechanisms2009

    • Author(s)
      Makita N, Shimizu W, Miyamoto K, Kamakura S, Horie M, Itoh H, Crotti L, Schwartz PJ, George AL Jr, Roden DM
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Brugada 症候群におけるSCN5A遺伝子変異と臨床像-他施設登録による検討-2009

    • Author(s)
      山形研一郎, 堀江稔, 赤尾昌治, 大江透, 草野研吾, 相澤義房, 山岸正和, 蒔田直昌, 小川聡, 田中敏博, 萩原誠久, 岸良示, 宮本恵宏, 鎌倉史郎, 清水渉
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 冠動脈洞開口以上を合併した防湿回帰性頻拍にカテーテル・アブレーションを施行し根治しえた1例2009

    • Author(s)
      伊藤英樹, 八尾武憲, 宮本証, 中澤優子, 城日加里, 水澤有香, 芦原貴司, 八木崇文, 横田良司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第21回 カテーテル・アブレーション委員会公開研究会
    • Place of Presentation
      埼玉
    • Related Report
      2009 Annual Research Report
  • [Presentation] Early Repolarization に関連した特発性心室細動の検討2009

    • Author(s)
      八尾武憲, 宮本証, 中津優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第25回心電情報処理ワークショップ
    • Place of Presentation
      有馬
    • Related Report
      2009 Annual Research Report
  • [Book] 心房細動。今日の治療指針 私はこう治療している2010年度版2010

    • Author(s)
      堀江稔
    • Total Pages
      3
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] ARB/ACE-Iによる心房細動抑止効果。Annual Review循環器20102010

    • Author(s)
      堀江稔
    • Total Pages
      7
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 脚ブロック。循環器疾患 最新の治療 2010-20112010

    • Author(s)
      堀江稔
    • Total Pages
      4
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Book] QT延長症候群 循環器疾患のサイエンス2010

    • Author(s)
      堀江稔
    • Total Pages
      5
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] II 疾患編4循環器疾患 QT延長症候群 今日の診断指針 第6版2010

    • Author(s)
      堀江稔
    • Total Pages
      3
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] QT延長症候群における突然死。心臓突然死を予知するための不整脈ノンインベイシブ検査2010

    • Author(s)
      水澤有香、堀江稔
    • Total Pages
      8
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] QT短縮症候群2010

    • Author(s)
      堀江稔
    • Total Pages
      4
    • Publisher
      医学のあゆみ
    • Related Report
      2010 Annual Research Report
  • [Book] 心不全 第4章 患者に学ぶ心不全の診断と治療3特定心筋症9不整脈源性右室心筋症2010

    • Author(s)
      堀江稔
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hqmedl/shiga_image/top.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hgmed1/shiga_image/top.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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