Study on effective treatment of infective endocarditis using sonoporation and nano-size bubble liposome

Research Project

Project/Area Number	21659201
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Circulatory organs internal medicine
Research Institution	Osaka University
Principal Investigator	NAKATANI Satoshi 大阪大学, 大学院・医学系研究科, 教授 (80393221)
Co-Investigator(Kenkyū-buntansha)	MARUYAMA Kazuo 帝京大学, 薬学部, 教授 (30130040) ASANUMA Toshihiko 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (80379271)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000) Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords	臨床心血管病態学 / 超音波治療 / ナノサイズバブル / バブルリポソーム / 血栓溶解
Research Abstract	Vegetation seen in infective endocarditis is covered by the biofilm which prevents effective penetration of antibiotics. We evaluated the feasibility of sonoporation as an aid of drug delivery to vegetation. We found combination of nano-size bubble liposomes and ultrasound exposure enhanced the ability of dye penetration to vegetation obtained from rat endocarditis model.

Report

(4 results)