Induction of differentiation from iPS cells to bronchioalveolar stem cells

• Project/Area Number: 21659207
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: KIKUCHI Toshiaki 東北大学, 病院, 講師 (10280926)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,540,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2009: ¥700,000 (Direct Cost: ¥700,000)
• Keywords: 閉塞性肺疾患 / 誘導多能性幹細胞 / 気管支肺胞上皮幹細胞 / 細胞・組織 / 発生・分化

Research Abstract

It is difficult to adopt the regenerative procedures to respiratory medicine for the anatomic complexity. However, regenerative procedures should be considered in respiratory medicine, which includes clinical states with irreversible tissue damage. In this research proposal, we have developed basic technologies that are demanded for induction of differentiation from iPS cells to bronchioalveolar stem cells.

Research Products

• [Journal Article] Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells (2012)
  • Author(s): Kanehira M, Kikuchi T, Ohkouchi S, Shibahara T, Tode N, Santoso A, Daito H, Ohta H, Tamada T, Nukiwa T
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1 (2012)
  • Author(s): Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T
  • Journal Title: Prockop DJ. Mol Ther Volume: 20 Pages: 417-23
  • Peer Reviewed
• [Journal Article] Usefulness of linezolid in the treatment of hospital-acquired pneumonia caused by MRSA : a prospective observational study (2012)
  • Author(s): Watanabe A, Goto H, Soma K, Kikuchi T, Gomi K, Miki H, Maemondo M, Ikeda H, Kuroki J, Wada H, Yokoyama T, Izumi S, Mitsutake K, Ueda Y
  • Journal Title: J Infect Chemother Volume: (in press)
  • Peer Reviewed
• [Journal Article] Runx1-deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells (2012)
  • Author(s): Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, Satake M
  • Journal Title: J Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Higher sensitivity of male CD4+ T cells to suppressive effects of CD8+ T cells on IL-5 production compared with female CD4+ T cells (2012)
  • Author(s): Okuyama K, Kashimura T, Kawano T, Ohkawara Y, Takayanagi M, Kikuchi T, Ohno I
  • Journal Title: Int Arch Allergy Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Mesenchymaal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1 (2012)
  • Author(s): Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
  • Journal Title: Mol Ther Volume: 20 Pages: 417-423
  • Peer Reviewed
• [Journal Article] Runx1-deficie ncy in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells (2012)
  • Author(s): Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, Satake M
  • Journal Title: J Immunol Volume: (未定)(印刷中)
  • Peer Reviewed
• [Journal Article] Antibacterial effects of brand-name teicoplanin and generic products against clinical isolates of methicillin-resistant Staphylococcus aureus (2011)
  • Author(s): Fujimura S, Fuse K, Takane H, Nakano Y, Gomi K, Kikuchi T, Watanabe A
  • Journal Title: J Infect Chemother Volume: 17 Pages: 30-3
  • NAID: 10027816661
  • Peer Reviewed
• [Journal Article] Antibacterial activity of carbapenems against clinical isolates of respiratory bacterial pathogens in the northeastern region of Japan in 2007 (2011)
  • Author(s): Gomi K, Fujimura S, Fuse K, Takane H, Nakano Y, Kariya Y, Kikuchi T, Kurokawa I, Tokue Y, Watanabe A
  • Journal Title: Watanabe A. J Infect Chemother Volume: 17 Pages: 200-6
  • NAID: 10028171398
  • Peer Reviewed
• [Journal Article] Risk factors for health care-associated pneumonia : transmission of multidrug-resistant Pseudomonas aeruginosa isolates from general hospitals to nursing homes (2011)
  • Author(s): Fujimura S, Nakano Y, Takane H, Kikuchi T, Watanabe A
  • Journal Title: Am J Infect Control Volume: 39 Pages: 173-5
  • Peer Reviewed
• [Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells (2011)
  • Author(s): Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T
  • Journal Title: Eur Respir J Volume: 38 Pages: 688-701
  • Peer Reviewed
• [Journal Article] Toll-like receptor 4 potentiates Ca2+-dependent secretion of electrolytes from swine tracheal glands (2011)
  • Author(s): Murakami K, Tamada T, Nara M, Muramatsu S, Kikuchi T, Kanehira M, Maruyama Y, Ebina M, Nukiwa T
  • Journal Title: Am J Respir Cell Mol Biol Volume: 45 Pages: 1101-10
  • Peer Reviewed
• [Journal Article] T cell subsets related with a sex difference in IL-5 production (2011)
  • Author(s): Okuyama K, Hamanaka Y, Kawano T, Ohkawara Y, Takayanagi M, Kikuchi T, Ohno I
  • Journal Title: Int Arch Allergy Immunol Volume: 1 Pages: 21-6
  • Peer Reviewed
• [Journal Article] 肺Mycobacterium avium感染症における病勢と菌遺伝子型との関連 (2011)
  • Author(s): 菊地利明
  • Journal Title: 東北医学雑誌 Volume: 123 Pages: 71-74
  • NAID: 10030263808
• [Journal Article] 肺MAC症の病勢と菌遺伝子型との関連 (2011)
  • Author(s): 菊地利明
  • Journal Title: 日本臨床 Volume: 69 Pages: 1444-1448
• [Journal Article] 結核と抗酸菌症の最近の話題 (2011)
  • Author(s): 菊地利明
  • Journal Title: 仙台市医師会報 Volume: 564 Pages: 34-34
• [Journal Article] Antibacterial activity of carbapenems against clinical isolates of respiratory bacterial pathogens in the northeastern region of Japan in 2007 (2011)
  • Author(s): Gomi K, Fujimura S, Fuse K, Takane H, Nakano Y, Kariya Y, Kikuchi T, Kurokawa I, Tokue Y, Watanabe A
  • Journal Title: J Infect Chemother Volume: 17 Issue: 2 Pages: 200-206
  • DOI: 10.1007/s10156-010-0112-2
  • NAID: 10028171398
  • Peer Reviewed
• [Journal Article] Mvcobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+CD11c+cells. (2011)
  • Author(s): 菊地利明, 他15名
  • Journal Title: Eur Respir J. Volume: 印刷中(未定)
  • Peer Reviewed
• [Journal Article] T cell subsets related Nith a sex difference in IL-15 production. (2011)
  • Author(s): 菊地利明, 他6名
  • Journal Title: Int Arch Allergy Immunol. Volume: 印刷中(未定)
  • Peer Reviewed
• [Journal Article] Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation (2010)
  • Author(s): Damayanti T, Kikuchi T, Zaini J, Daito H, Kanehira M, Kohu K, Ishii N, Satake M, Sugamura K, Nukiwa T
  • Journal Title: Am J Respir Crit Care Med Volume: 181 Pages: 688-98
  • Peer Reviewed
• [Journal Article] Transbronchial human interleukin-10 gene transfer reduces acute inflammation associated with allograft rejection and intragraft interleukin-2 and tumor necrosis factor-alpha gene expression in a rat model of lung transplantation (2010)
  • Author(s): Oishi H, Okada Y, Kikuchi T, Hoshikawa Y, Sado T, Noda M, Endo C, Sakurada A, Matsumura Y, Kondo T
  • Journal Title: J Heart Lung Transplant Volume: 29 Pages: 360-7
  • Peer Reviewed
• [Journal Article] 市中病院NICUにおけるAcinetobacter baumanniiの分離状況 (2010)
  • Author(s): 高根秀成, 藤村茂, 中野禎久, 布施克浩, 五味和紀, 菊地利明, 貫和敏博, 渡辺彰
  • Journal Title: 日本環境感染学会誌 Volume: 25 Pages: 242-246
  • NAID: 10027660799
  • Peer Reviewed
• [Journal Article] 肺Mycobacterium avium感染症における病勢と菌遺伝子型との関連 (2010)
  • Author(s): 菊地利明
  • Journal Title: 結核 Volume: 85 Pages: 809-813
  • NAID: 10030263808
  • Peer Reviewed
• [Journal Article] 非結核性抗酸菌症の予後と治療適応 (2010)
  • Author(s): 菊地利明
  • Journal Title: Modern Physician Volume: 30 Pages: 707-709
• [Journal Article] Serial OX40 engagement on CD4+T cells and natural killer T cells causes allergic airway inflammation. (2010)
  • Author(s): 菊地利明, 他9名
  • Journal Title: Am J Respir Crit Care Med Volume: 181 Pages: 688-698
  • Peer Reviewed
• [Journal Article] Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation (2010)
  • Author(s): Damayanti T, et al.
  • Journal Title: Am J Respir Crit Care Med. 181 Pages: 688-698
  • Peer Reviewed
• [Journal Article] Regulation of adenosine 5'-triphosphate (ATP)-gated P2X(4)receptors on tracheal smooth muscle cells (2009)
  • Author(s): Nagaoka M, Nara M, Tamada T, Kume H, Oguma T, Kikuchi T, Zaini J, Moriya T, Ichinose M, Tamura G, Hattori T
  • Journal Title: Respir Physiol Neurobiol Volume: 166 Pages: 61-7
  • Peer Reviewed
• [Journal Article] Association between mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection (2009)
  • Author(s): Kikuchi T, Watanabe A, Gomi K, Sakakibara T, Nishimori K, Daito H, Fujimura S, Tazawa R, Inoue A, Ebina M, Tokue Y, Kaku M, Nukiwa T
  • Journal Title: Thorax Volume: 64 Pages: 901-7
  • Peer Reviewed
• [Journal Article] Efficacy of clarithromycin plus vancomycin in mice with implant-related infection caused by biofilm-forming Staphylococcus aureus (2009)
  • Author(s): Fujimura S, Sato T, Kikuchi T, Zaini J, Gomi K, Watanabe A
  • Journal Title: J Orthop Sci Volume: 14 Pages: 658-61
  • NAID: 10025588545
  • Peer Reviewed
• [Journal Article] 臨床分離されたPseudomonas aeruginosaに対するarbekacinの抗菌力(2003年～2007年) (2009)
  • Author(s): 藤村茂, 五味和紀, 高根秀成, 中野禎久, 布施克浩, 菊地利明, 徳江豊, 渡辺彰
  • Journal Title: 日本化学療法学会雑誌 Volume: 57 Pages: 91-96
  • NAID: 10024798606
  • Peer Reviewed
• [Journal Article] 下腿の腫脹, 皮疹と多発リンパ節腫大で発症し呼吸不全に進展したM. szulgaiの1症例 (2009)
  • Author(s): 太田洋充, 佐藤栄三郎, 小野学, 五味和紀, 菊地利明, 海老名雅仁, 貫和敏博, 手塚文明
  • Journal Title: 日本内科学会雑誌 Volume: 98 Pages: 1984-1986
  • NAID: 10025193442
  • Peer Reviewed
• [Journal Article] Association between mycobacterial genotypes and disease progression in Mycobac terium avium pulmonary infection (2009)
  • Author(s): Kikuchi T, et al.
  • Journal Title: Thorax. 64 Pages: 901-907
  • Peer Reviewed
• [Journal Article] Efficacy of clarithromycin plus vancomycin in mice with implant-related infection caused by biofilm-forming Staphylococcus aureus (2009)
  • Author(s): Fujimura S, et al.
  • Journal Title: J Orthop Sci. 14 Pages: 658-661
  • Peer Reviewed
• [Presentation] MRSA感染症の診断と治療 (2012)
  • Author(s): 菊地利明
  • Organizer: 東四国医療セミナー
  • Place of Presentation: 徳島
  • Year and Date: 2012-03-08
• [Presentation] 肺MAC症の薬物治療 (2012)
  • Author(s): 菊地利明
  • Organizer: 第22回みやぎ薬剤師学術研修会
  • Place of Presentation: 仙台
  • Year and Date: 2012-02-18
• [Presentation] 結核?の連絡を受けたら (2012)
  • Author(s): 菊地利明
  • Organizer: 平成23年度第10回感染対策実務委員会
  • Place of Presentation: 仙台
  • Year and Date: 2012-02-14
• [Presentation] 非結核性抗酸菌症? 感染症とアレルギーのクロストーク (2012)
  • Author(s): 菊地利明
  • Organizer: 第23回日本臨床微生物学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-01-21
• [Presentation] 非結核性抗酸菌症?感染症とアレルギーのクロストーク (2012)
  • Author(s): 菊地利明
  • Organizer: 第23回日本臨床微生物学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-01-21
• [Presentation] 冬の健康管理-呼吸器感染の予防について (2011)
  • Author(s): 菊地利明
  • Organizer: 東北学院同窓会TG十五日会
  • Place of Presentation: 仙台
  • Year and Date: 2011-11-15
• [Presentation] ナフタレン気道炎症モデルにおける酸化ストレス (2011)
  • Author(s): 柴原泰三, 菊地利明, 貫和敏博
  • Organizer: 第2回癌・炎症とαリポ酸研究会
  • Place of Presentation: 別府
  • Year and Date: 2011-11-11
• [Presentation] 感染症とアレルギーの関係を考える: hot tub lungの病態解明 (2011)
  • Author(s): 菊地利明
  • Organizer: 日本薬学会東北支部第10回生物化学若手研究者セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-08
• [Presentation] 感染症とアレルギーの関係を考える:hot tub lungの病態解明 (2011)
  • Author(s): 菊地利明
  • Organizer: 日本薬学会東北支部第10回生物化学若手研究者セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-08
• [Presentation] STC1はUCP2誘導を介した過酸化ストレス軽減と非共役呼吸誘導を通して肺がん細胞の生存を誘導する (2011)
  • Author(s): 大河内眞也, 菊地利明, 海老名雅仁, 貫和敏博
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] Novel functions of stanniocalcin-1 (STC1)through uncoupling protein 2 (UCP2)up-regulation ; promoting survival of cancer cells under oxidative stress and inducing the uncoupling respiration (Warburg effect) (2011)
  • Author(s): Ohkouchi S, Kikuchi T, Ebina M, Nukiwa T
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: Amsterdam (オランダ)
  • Year and Date: 2011-09-24
• [Presentation] Secretory leukoprotease inhibitor plays an essential role in lung inflammation after naphthalene induction (2011)
  • Author(s): Damayanti T, Kikuchi T, Nukiwa T.
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: Amsterdam (オランダ)
  • Year and Date: 2011-09-24
• [Presentation] Novel functions of stanniocalcin-1 (STC1) through uncoupling protein 2 (UCP2) up-regulation ; promoting survival of cancer cells under oxidative stress and inducing the uncoupling respiration (Warburg effect) (2011)
  • Author(s): Ohkouchi S, Kikuchi T, Ebina M, Nukiwa T
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: Amsterdam,オランダ
  • Year and Date: 2011-09-24
• [Presentation] Secretory leukoprotease inhibitor plays an essential role in lung inflammation after naphthalene induction (2011)
  • Author(s): Damayanti T, Kikuchi T, Nukiwa T
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: Amsterdam,オランダ
  • Year and Date: 2011-09-24
• [Presentation] 呼吸器感染症についての最新知見 (2011)
  • Author(s): 菊地利明
  • Organizer: 第21回青葉画像研究会
  • Place of Presentation: 仙台
  • Year and Date: 2011-07-22
• [Presentation] 抗酸菌症についての最近の進歩 (2011)
  • Author(s): 菊地利明
  • Organizer: 第46回秋田呼吸器疾患フォーラム
  • Place of Presentation: 秋田
  • Year and Date: 2011-07-07
• [Presentation] 結核・抗酸菌症の最近の話題 (2011)
  • Author(s): 菊地利明
  • Organizer: 第258回仙台呼吸器疾患勉強会
  • Place of Presentation: 仙台
  • Year and Date: 2011-06-14
• [Presentation] 非結核性抗酸菌による過敏性肺臓炎「hot tub lung」の病態解明 (2011)
  • Author(s): 菊地利明, 渡辺彰, 貫和敏博
  • Organizer: 第86回日本結核病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] 感染と宿主免疫応答, そして急性肺傷害 (2011)
  • Author(s): 菊地利明
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-19
• [Presentation] 感染と宿主免疫応答,そして急性肺傷害 (2011)
  • Author(s): 菊地利明
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-19
• [Presentation] Toll-Like receptor 4 signaling as a potentiator in the airway submucosal gland secretion (2011)
  • Author(s): Murakami K, Tamada T, Nara M, Muramatsu S, Kikuchi T, Kanehira M, Ebina M, Nukiwa T.
  • Organizer: American Thoracic Society 2011 International Conference
  • Place of Presentation: Denver (米国)
  • Year and Date: 2011-05-13
• [Presentation] Toll-like receptor 4 signaling as a potentiator in the airway submucosal gland secretion (2011)
  • Author(s): Murakami K, Tamada T, Nara M, Muramatsu S, Kikuchi T, Kanehira M, Ebina M, Nukiwa T
  • Organizer: American Thoracic Society 2011 International Conference
  • Place of Presentation: Denver,米国
  • Year and Date: 2011-05-13
• [Presentation] Deletion of Slpi reduces lung inflammation after naphtalene induction (2011)
  • Author(s): Damayanti T, Santoso A, Kikuchi T, Nukiwa T
  • Organizer: American Thoracic Society 2011 International Conference
  • Place of Presentation: Denver,米国
  • Year and Date: 2011-05-13
• [Presentation] Deletion of SLPI reduces lung inflammation after naphthalene induction (2011)
  • Author(s): Damayanti T, Santoso A, Kikuchi T, Nukiwa T.
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] 間葉系幹細胞(MSCs)由来ミトコンドリア関連ホルモンSTC1を用いた肺微小環境恒常性維持の可能性 (2011)
  • Author(s): 大河内眞也, 千葉茂樹, 菊地利明, 海老名雅仁, 貫和敏博
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] Hot tub lung動物実験モデルにおいて肺CD11b+ 樹状細胞はTLR9-MyD88経路依存性に炎症を惹起する (2011)
  • Author(s): 大東久佳, 菊地利明, 東出直樹, 海老名雅仁, 渡辺彰, 貫和敏博
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] Hot tub lung動物実験モデルにおけるNKT細胞の役割 (2011)
  • Author(s): 東出直樹, 菊地利明, 大東久佳, 海老名雅仁, 渡辺彰, 貫和敏博
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] IL-5産生の性差に関与するT細胞サブセットの解析 (2011)
  • Author(s): 奥山香織, 濱中悠賀, 河野資, 大河原雄一, 高柳元明, 菊地利明, 大野勲
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] 気道粘膜下腺細胞におけるToll様受容体4シグナリングによる分泌調節機序の検討 (2011)
  • Author(s): 村上康司, 玉田勉, 奈良正之, 村松聡士, 菊地利明, 兼平雅彦, 海老名雅仁, 貫和敏博
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] Deletion of SLPI Reduces Lung Inflammation after Naphtalene Induction (2011)
  • Author(s): Damayanti T, Santoso A, Kikuchi T, Nukiwa T
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] Hot tub lung動物実験モデルにおいて肺CD11b+樹状細胞はTLR9-MyD88経路依存性に炎症を惹起する (2011)
  • Author(s): 大東久佳, 菊地利明, 東出直樹, 海老名雅仁, 渡辺彰, 貫和敏博
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] RT-PCR法を用いたpyocyanin産生遺伝子phzMの発現に関する検討 (2011)
  • Author(s): 布施克浩, 藤村茂, 菊地利明, 高根秀成, 中野禎久, 渡辺彰
  • Organizer: 第45回緑膿菌感染症研究会
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-04
• [Presentation] 感染症とアレルギー:非結核性抗酸菌症の二面性 (2011)
  • Author(s): 菊地利明
  • Organizer: 第45回緑膿菌感染症研究会
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-04
• [Presentation] Deletion of Slpi reduces lung inflammation after naphtalene induction. (2011)
  • Author(s): Damayanti T, Santoso A, Kikuchi T, Nukiwa T.
  • Organizer: American Thoracic Society
  • Place of Presentation: Denver (米国)
• [Presentation] Reverse transcription-polymerase chain reaction (RT-PCR)法を用いたMBL産生緑膿菌のpyocyanin産生に関する検討 (2010)
  • Author(s): 布施克浩, 藤村茂, 菊地利明, 高根秀成, 中野禎久, 渡辺彰
  • Organizer: 第59回日本感染症学会東日本地方会学術集会第57回日本化学療法学会東日本支部総会合同学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-21
• [Presentation] 肺癌細胞株PC9 (EGFR deletion)とA549 (k-ras Ser)におけるside population, self seeding, 肺xenograft形成 (2010)
  • Author(s): 貫和紀子, 謝勉, 福原達朗, Cezary Treda, 菊地利明, 海老名雅仁, 貫和敏博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 関節リウマチ治療中に結核性腹膜炎と性器結核を発症した一例 (2010)
  • Author(s): 鳴海創大, 佐々木陽彦, 井上彰, 菊地利明, 海老名雅仁, 貫和敏博
  • Organizer: 第121回日本結核病学会東北支部学会
  • Place of Presentation: 山形
  • Year and Date: 2010-09-04
• [Presentation] OX40-OX40L interaction on CD4 T cells and NKT cells contribute to the development of allergic airway inflammation. (2010)
  • Author(s): Damayanti T, Zaini J, Kikuchi T, Nukiwa T.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-23
• [Presentation] 非結核性抗酸菌症は治療すべきかMACを中心にProの立場から (2010)
  • Author(s): 菊地利明
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-20
• [Presentation] 肺Mycobacterium avium感染症における病勢と菌遺伝子型との関連 (2010)
  • Author(s): 菊地利明
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-20
• [Presentation] Development of a mouse model for hot tub lung (2010)
  • Author(s): Daito H, Kikuchi T, Gomi K, Ebina M, Nukiwa T.
  • Organizer: American Thoracic Society 2010 International Conference
  • Place of Presentation: New Orleans (米国)
  • Year and Date: 2010-05-14
• [Presentation] Development of a mouse model for hot tub lung. (2010)
  • Author(s): 菊地利明, 他4名
  • Organizer: ATS 2010 International Conference
  • Place of Presentation: 米国・ニューオリンズ
  • Year and Date: 2010-05-14
• [Presentation] OX40-OX40L interactions on NKT cells contribute to development of airway inflammation in mouse model of allergic airway inflammation (2010)
  • Author(s): T, Zaini J, Kikuchi T, Nukiwa T.
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23
• [Presentation] 抗菌薬治療ではde-escalationを行うべきである (2010)
  • Author(s): 菊地利明
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23
• [Presentation] 気道粘膜下腺細胞におけるToll様受容体シグナリングによる分泌調節機序の検討 (2010)
  • Author(s): 村上康司, 玉田勉, 奈良正之, 菊地利明, 海老名雅仁, 貫和敏博
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23
• [Presentation] 間葉系幹細胞(MSCs)分泌Stanniocalcin 1(STC1)が誘導するUncoupling Protein 2 (UCP2)依存性Reactive Oxygen Species (ROS)抑制作用とWarburg効果 (2010)
  • Author(s): 大河内眞也, ahmed Katcha, 兼平雅彦, 菊地利明, 海老名雅仁, 貫和敏博
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23
• [Presentation] 非結核性抗酸菌による過敏性肺臓炎動物実験モデルの確立・病態解明 (2010)
  • Author(s): 大東久佳, 菊地利明, 五味和紀, 渡辺彰, 貫和敏博
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23
• [Presentation] Cancer Immunology : what we have achieved and clinical implications (2010)
  • Author(s): Kikuchi T
  • Organizer: PIPKRA 2010
  • Place of Presentation: Jakarta (インドネシア)
  • Year and Date: 2010-02-13
• [Presentation] Translational medicine in mycobacterial disease (2010)
  • Author(s): Kikuchi T
  • Organizer: PIPKRA 2010
  • Place of Presentation: Jakarta (インドネシア)
  • Year and Date: 2010-02-13
• [Presentation] Translational Medicine in Mycobacterial Disease (2010)
  • Author(s): Toshiaki Kikuchi
  • Organizer: PIPKRA Scientific Respiratory Meeting
  • Place of Presentation: Jakarta(インドネシア)
  • Year and Date: 2010-02-13
• [Presentation] 抗酸菌におけるバイオセーフティー (2009)
  • Author(s): 菊地利明
  • Organizer: 第9回バイオセーフティー学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-12-10
• [Presentation] 多型縦列反復配列(VNTR)の菌遺伝子型による非結核性抗酸菌症の病勢予測 (2009)
  • Author(s): 菊地利明, 渡辺彰, 五味和紀, 藤村茂, 西森敬, 貫和敏博
  • Organizer: 第84回日本結核病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-07-02
• [Presentation] The role of OX40-OX40 ligand interactions on NKT Cells in mouse model of allergic airway inflammation (2009)
  • Author(s): Damayanti T, Zaini J, Kikuchi T, Nukiwa T
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] 多型縦列反復配列(VNTR)の菌遺伝子型による非結核性抗酸菌症の病勢予測 (2009)
  • Author(s): 菊地利明, 渡辺彰, 五味和紀, 榊原智博, 海老名雅仁, 貫和敏博
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] 嚢胞性線維症で呼吸器感染症を繰り返し, 肺移植を検討するに至った一例 (2009)
  • Author(s): 三橋善哉, 五味和紀, 大東久佳, 菊地利明, 海老名雅仁, 渡辺彰, 貫和敏博
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] 非結核性抗酸菌による過敏性肺炎動物実験モデルの確立 (2009)
  • Author(s): 大東久佳, 菊地利明, 榊原智博, 五味和紀, 渡辺彰, 貫和敏博
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] メタロ-β-ラクタマーゼ産生Pseudomonas aeruginosaにおけるpyocyanin産生について (2009)
  • Author(s): 布施克浩, 藤村茂, 五味和紀, 菊地利明, 高根秀成, 中野禎久, 渡辺彰, 貫和敏博
  • Organizer: 第57回日本化学療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-03
• [Presentation] A mouse model for hot tub lung by using Mycobacterium avium from the patient (2009)
  • Author(s): Daito H, Kikuchi T, Zaini J, Sakakibara T, Gomi K, Ebina M, Watanabe A, Nukiwa T
  • Organizer: American Thoracic Society 2009 International Conference
  • Place of Presentation: San Diego(米国)
  • Year and Date: 2009-05-15
• [Book] 寄生虫, リケッチャによる肺感染症呼吸器疾患最新の治療2013-2015 (2012)
  • Author(s): 西巻雄司, 菊地利明貫和敏博/杉山幸比古/門田淳一
  • Publisher: 南江堂, 東京(印刷中)
• [Book] 呼吸器疾患最新の治療2013-2015 (2012)
  • Author(s): 西巻雄司, 菊地利明
  • Publisher: 南江堂(印刷中)
• [Book] 抗菌薬の正しい使い方呼吸器研修ノート (2011)
  • Author(s): 菊地利明萩原弘一/芦澤和人/大泉聡史/沖永壮治/服部登/星川康編
  • Publisher: 診断と治療社, 東京
• [Book] 抗菌薬治療におけるde-escalation (2011)
  • Author(s): 菊地利明渡辺彰/二木芳人/青木洋介
  • Publisher: 南江堂, 東京
• [Book] 第45回緑膿菌感染症研究会講演記録 (2011)
  • Author(s): 菊地利明
  • Total Pages: 106
  • Publisher: 緑膿菌感染症研究会事務局
• [Book] 呼吸器研修ノート (2011)
  • Author(s): 菊地利明
  • Total Pages: 840
  • Publisher: 診断と治療社
• [Book] 感染症診療Pro&Con (2011)
  • Author(s): 菊地利明
  • Total Pages: 165
  • Publisher: 南江堂
• [Book] 非結核性抗酸菌症呼吸器疾患最新の治療 (2010)
  • Author(s): 菊地利明貫和敏博/杉山幸比古/門田淳一
  • Publisher: 南江堂, 東京
• [Book] レジオネラに遭遇したら抗菌薬PK-PD実践テクニック (2010)
  • Author(s): 菊地利明渡辺彰/藤村茂
  • Publisher: 南江堂, 東京
• [Book] 抗菌薬PK-PD実践テクニック (2010)
  • Author(s): 菊地利明, 他29名
  • Total Pages: 160
  • Publisher: 南江堂
• [Book] 呼吸器疾患 最新の治療 2010-2012 (2010)
  • Author(s): 菊地利明
  • Total Pages: 507
  • Publisher: 南江堂
• [Remarks]
  • URL: http://www.rm.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.rm.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.kokyuu.med.tohoku.ac.Jp/
• [Remarks]
  • URL: http://www.kokyuu.med.tohoku.ac.jp/
• [Patent(Industrial Property Rights)] リゾリン脂質シグナル制御による幹細胞の維持増殖培養法 (2012)
  • Inventor(s): 菊地利明, 兼平雅彦, 貫和敏博
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Industrial Property Number: 2012-001441
  • Filing Date: 2012-01-06
• [Patent(Industrial Property Rights)] VNTR型別による非結核性抗酸菌症の病勢の予測方法 (2010)
  • Inventor(s): 菊地利明, 他5名
  • Industrial Property Rights Holder: 東北大学
  • Patent Publication Number: 2010-142150
  • Filing Date: 2010-07-01
• [Patent(Industrial Property Rights)] VNTR型別による非結核性抗酸菌症の病勢の予測方法
  • Inventor(s): 貫和敏博, 渡辺彰, 五味和紀, 榊原智博, 菊地利明, 西森敬
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Patent Publication Number: 2010-142150