| Project/Area Number |
21659211
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SHIMOUCHI Akito 独立行政法人国立循環器病研究センター, 心臓生理機能部, 室長 (80211291)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUBARA Ichiro 産業技術総合研究所, 先進製造プロセス研究部門, 研究グループ長 (40344220)
SHIN Wosuck 産業技術総合研究所, 先進製造プロセス研究部門, 主任研究員 (10357246)
NISHIBORI Maiko 産業技術総合研究所, 先進製造プロセス研究部門, 研究員 (20462848)
SHIRAI Mikiyasu 独立行政法人国立循環器病研究センター, 心臓生理機能部, 部長 (70162758)
SATA Makoto 独立行政法人国立循環器病研究センター, 呼吸器科, 医長 (00280892)
KONDO Takaharu 中部大学, 生命健康科学部, 教授 (20135388)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | 水素 / 酸化ストレス / 肺循環障害 / 生活習慣 / 水素ガス / 水素水 / 熱電型水素センサ / モノクロタリン肺高血圧症 / 急性一酸化炭素中毒 |
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| Research Abstract |
It is reported that molecular hydrogen is a weak but selective scavenger against hydroxyl radicals. This study hypothesized that molecular hydrogen consumption after ingestion of hydrogen water reflects production of reactive oxygen species. We developed a new method to estimate hydroxyl radical production in the whole body by the mass-balance of ingested and exhaled hydrogen. We also developed a hydrogen sensor and evaluated for clinical use. Furthermore, we explored hydrogen-producing dietary foods and found that breath hydrogen originated from colonic fermentation significantly correlated with biological antioxidant potentials
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