| Project/Area Number |
21659214
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
TERADA Yoshio 高知大学, 教育研究部・医療学系, 教授 (30251531)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 腎障害 / オートファジー / リソゾーム / マイトファジー / 腎臓 / アポトーシス / 急性腎障害 / 再生医学 / 尿細管 / 虚血 / 慢性腎臓病 / 急性腎不全 / 慢性腎障害 / 透析療法 |
|---|
| Research Abstract |
Recently some reports indicate that BNIP3 and sestrin 2 induce autophagy, and autophagy has a protective roles in acute kidney injury(AKI). Autophagy is thought to play an important role for preventing AKI from stresses. We evaluate the expression of BNIP3 and sestrin 2 protein and mRNA in renal tubular cells in vitro and in vivo. Sestrin 2 is increasing in stresses including hypoxia, oxidative stress, ischemia/ reperfusion condition. We conclude that BNIP3 and sestrin2 is induced by stresses, and it induce renal tubular cells to autophagy. Sestrin 2 is thought to have a protective role in AKI.
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