Involvement of autopgaly and lysosomal system in renal diseases
| Project/Area Number |
21659214
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
TERADA Yoshio 高知大学, 教育研究部・医療学系, 教授 (30251531)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | 腎障害 / オートファジー / リソゾーム / マイトファジー / 腎臓 / アポトーシス / 急性腎障害 / 再生医学 / 尿細管 / 虚血 / 慢性腎臓病 / 急性腎不全 / 慢性腎障害 / 透析療法 |
|---|
| Research Abstract |
Recently some reports indicate that BNIP3 and sestrin 2 induce autophagy, and autophagy has a protective roles in acute kidney injury(AKI). Autophagy is thought to play an important role for preventing AKI from stresses. We evaluate the expression of BNIP3 and sestrin 2 protein and mRNA in renal tubular cells in vitro and in vivo. Sestrin 2 is increasing in stresses including hypoxia, oxidative stress, ischemia/ reperfusion condition. We conclude that BNIP3 and sestrin2 is induced by stresses, and it induce renal tubular cells to autophagy. Sestrin 2 is thought to have a protective role in AKI.
|
Report
(4 results)
Research Products
(80 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article]2009
Author(s)
堀野太郎, 寺田典生
-
Journal Title
電解質異常. 高・低Na血症, 高・低Cl血症. 専門医のための腎臓病学(医学書院)
Pages: 115-121
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
