Metagenomic analysis of Parkinson's disease patients' gut microflora
| Project/Area Number |
21659219
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWATA Atsushi 東京大学, 医学部附属病院, 特任准教授 (40401038)
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| Co-Investigator(Kenkyū-buntansha) |
KOWA Hisatomo 神戸大学, 医学部附属病院, 准教授 (60396728)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,290,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | 神経分子病態学 / メタゲノミクス / パーキンソン病 / 腸内細菌 |
|---|
| Research Abstract |
As a cause of sporadic Parkinson's disease, we hypothesized that the gut microflora in patients might be compromised. We took 10 stool samples and extracted DNA from patients and compared with 10 control samples. DGGE analysis revealed three distinctive bands in the patient group, which was sequenced and identified. Further analysis of large number samples are needed to confirm the result.
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Report
(4 results)
Research Products
(39 results)
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[Presentation] Age Effect on Cerebral Blood Flow in Adults Using Pseudo-Continuous ASL2011
Author(s)
Kazushi Suzuki, Yuri Koide, Wataru Gonoi, Toshihiro Hayashi, Kenichi Aizawa, Kurumi Fujii, Masaki Katsura, Shinya Kodashima, Yoshiko Mizuno1, Tomoko Nakao, Yumiko Ooike, Toru Suzuki, Shoji Tsuji, Tsutomu Yamazaki, Akira Kunimatsu, Atsushi Iwata
Organizer
17th annual meeting of the Organization on Human Brain Mapping
Place of Presentation
Quebec City, QC, Canada
Year and Date
2011-06-27
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[Presentation] Occipital hypoperfusion in Lewy body disease with visual hallucinations using pseudo-continuous arterial spin labeling MRI2011
Author(s)
Yuri Koide, Toshihiro Hayashi, W Gonoi, M Katsura, A Kunimatsu, Shoji Tsuji, Atsushi Iwata
Organizer
Society for Neuroscience
Place of Presentation
Yuri Koide, Toshihiro Hayashi, W Gonoi, M Katsura, A Kunimatsu, Shoji Tsuji, Atsushi Iwata
Related Report
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[Presentation] The early detection of cognitive deterioration in normal populations attending medical checkups of the brain2010
Author(s)
Kazushi Suzuki, Hisatomo Kowa, Yumiko Ooike, Motoko Seto, Kenichi Aizawa, Toru Suzuki, Tsutomu Yamazaki, Shoji Tsuji, Atsushi Iwata
Organizer
ICAD 2010
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-07-12
Related Report
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[Presentation] A family of leukoencephalopathy, dementia, tremor, peripheral neuropathy and retinitis pigmentosa : a clinical description2010
Author(s)
Ryo Ohtomo, Yuichiro Shirota, Hiroyuki Ishiura, Hisatomo Kowa, Shoji Tsuji, Atsushi Iwata
Organizer
ICAD 2010
Place of Presentation
Honolulu, HI, USA
Year and Date
2010-07-11
Related Report
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