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transcranial direct current stimulation : a potential treatment of depression

Research Project

Project/Area Number 21659274
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionUniversity of Yamanashi

Principal Investigator

MOTOHASHI Nobutaka  山梨大学, 大学院・医学工学総合研究部, 教授 (30166342)

Co-Investigator(Renkei-kenkyūsha) KITAHARA Yuichi  山梨大学, 大学院・医学工学総合研究部, 助教 (00436859)
FUJII Tomokazu  山梨大学, 大学院・医学工学総合研究部, 助教 (30456454)
YASUDA Kazuyuki  山梨大学, 医学部・附属病院, 助教 (90456442)
YAMAGUCHI Masayasu  山梨大学, 医学部・附属病院, 医員 (90568263)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,970,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords精神生理学 / うつ病 / 経頭蓋直流刺激 / 背外側前頭前野 / POMS / 認知機能 / 再認記憶 / 経頭蓋磁気刺激 / ドパミン / 近赤外線スペクトロスコピー / 脳血流 / 脳刺激 / 治療法
Research Abstract

The effects of repeated transcranial direct current stimulation(tDCS) on mood and neurocognitive function were investigated by applying anodal stimulation over the left dorsolateral prefrontal cortex(DLPFC). We recruited healthy male participants for this single-blind, sham-controlled crossover trial. We used Profile of Mood States, brief-form(POMS) and CogHealth to evaluate the changes in mood and neurocognitive function, respectively, before, and immediately after4-daily anodal or sham tDCS. While there were no significant changes in six factors of POMS and performance(speed and accuracy) of CogHealth between sham and anodal stimulation, accuracy of a visual recognition memory task was increased at the end of experiment. Furthermore, these changes were pronounced in the group started with anodal stimulation. These results suggest that4-daily anodal tDCS over left DLPFC might improve visual recognition learning without deleterious effects in healthy subjects and further support the view that tDCS is a potential treatment of depression.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2012 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (7 results) Book (10 results)

  • [Journal Article] パルス波ECTの現状と導入を振り返って2012

    • Author(s)
      本橋伸高
    • Journal Title

      総合病院精神医学

      Volume: (印刷中)

    • NAID

      10031146133

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in cerebral blood flow between missed and generalized seizures with electroconvulsive therapy : A positron emission tomographic study2011

    • Author(s)
      Takano H, Motohashi N, Uema T, Ogawa K, Ohnishi T, Nishikawa M, Matsuda H
    • Journal Title

      Epilepsy Research

      Volume: 97(1-2) Pages: 225-228

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 難治性気分障害の治療:エビデンスレビュー難治性うつ病に対するECT/TMS治療2011

    • Author(s)
      本橋伸高
    • Journal Title

      臨床精神医学

      Volume: 40(1) Pages: 109-115

    • NAID

      40018278793

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in cerebral blood flow between missed and generalized seizures with electroconvulsive therapy : A positron emission tomographic study2011

    • Author(s)
      Takano H, Motohashi N, ほか5名
    • Journal Title

      Epilepsy Research

      Volume: 97 Issue: 1-2 Pages: 225-228

    • DOI

      10.1016/j.eplepsyres.2011.08.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 難治性うつ病.今日の精神科治療ガイドライン2010

    • Author(s)
      本橋伸高
    • Journal Title

      精神科治療学

      Volume: 25 Pages: 140-141

    • Related Report
      2011 Final Research Report
  • [Journal Article] 電気けいれん療法(ECT)のわが国での現況:全国実態調査の結果から総合病院精神科に求められること2010

    • Author(s)
      奥村正紀, 鮫島達夫, 粟田主一, 鹿島晴雄, 本橋伸高, 澤温, 和田健, 分島徹, 川嵜弘詔, 中村満, 山口成良, 一瀬邦弘, 大久保善朗
    • Journal Title

      総合病院精神医学

      Volume: 22 Pages: 105-118

    • NAID

      10027882353

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] World Federation of Societies of Biological Psychiatry(WFSBP) guidelines on brain stimulation treatments in psychiatry2010

    • Author(s)
      Schlaepfer T, Mark G
    • Journal Title

      The World Journal of Biological Psychiatry

      Volume: 11 Pages: 2-18

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic repetitive transcranial magnetic stimulation failed to change dopamine synthesis rate: Preliminary L-[SS-11C]DOPA PET study in patients with depression2010

    • Author(s)
      Kuroda Y
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 64 Pages: 659-662

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 難治性うつ病2010

    • Author(s)
      本橋伸高
    • Journal Title

      精神科治療学

      Volume: 25(増刊) Pages: 140-141

    • Related Report
      2010 Annual Research Report
  • [Journal Article] World Federation of Societies of Biological Psychiatry (WFSBP) guidelines on brain stimulation treatments in psychiatry2010

    • Author(s)
      Schlaepfer T, et al.
    • Journal Title

      World Journal of Biological Psychiatry 11

      Pages: 2-18

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 電気けいれん療法は変わった2010

    • Author(s)
      本橋伸高
    • Journal Title

      医学のあゆみ 最新 うつ病のすべて (別冊)

      Pages: 100-103

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 難治性うつ病に対する非薬物療法の展望:生物学的側面2009

    • Author(s)
      本橋伸高
    • Journal Title

      臨床精神薬理

      Volume: 12(5) Pages: 859-865

    • Related Report
      2011 Final Research Report
  • [Journal Article] Suhara T : Chronic repetitive transcranial magnetic stimulation failed to change dopamine synthesis rate : Preliminary L-[β-11C] DOPAPET study in patients with depression2009

    • Author(s)
      Kuroda Y, Motohashi N, Ito H, Ito S, Takano A, Takahashi H, Nishikawa T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 64 Pages: 659-665

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] パルス波ECTの現状と導入を振り返って2011

    • Author(s)
      本橋伸高
    • Organizer
      第24回総合病院精神医学会総会
    • Place of Presentation
      福岡国際会議場(福岡)(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 気分障害の脳刺激療法2011

    • Author(s)
      本橋伸高
    • Organizer
      第30回躁うつ病の薬理・生化学的研究懇話会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 気分障害の脳刺激療法2011

    • Author(s)
      本橋伸高
    • Organizer
      第30回躁うつ病の薬理・生化学的研究懇話会
    • Place of Presentation
      京都ガーデンホテル(京都)(招待講演)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ECT実態調査の報告2010

    • Author(s)
      本橋伸高, ほか10
    • Organizer
      第106回日本精神神経学会総会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ECT practice in Japan2009

    • Author(s)
      Motohashi N
    • Organizer
      Parallel7-5Electroconvulsive Therapy in Asia, 2nd World Congress of Asian Psychiatry
    • Place of Presentation
      Taipei
    • Year and Date
      2009-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ECTpractice in Japan2009

    • Author(s)
      Motohashi N
    • Organizer
      2nd World Congress of Asian Psychiatry
    • Place of Presentation
      Taipei
    • Year and Date
      2009-11-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] うつ病治療における磁気刺激:現状と課題2009

    • Author(s)
      本橋伸高
    • Organizer
      第31回日本生物学的精神医学会,シンポジウム2磁気刺激療法の精神疾患への応用
    • Place of Presentation
      京都
    • Year and Date
      2009-04-23
    • Related Report
      2011 Final Research Report
  • [Book] 気分障害の電気刺激療法.気分障害の薬理と生化学ー総括と新たなる挑戦ー2012

    • Author(s)
      本橋伸高
    • Publisher
      医薬ジャーナル
    • Related Report
      2011 Final Research Report
  • [Book] 電気けいれん療法(ECT),今日の精神疾患治療指針2012

    • Author(s)
      本橋伸高,樋口輝彦,市川宏伸,神庭重信,朝田隆,中込和幸
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 気分障害の薬理・生化学-総括と新たなる挑戦-(躁うつ病の薬理・生化学的研究懇話会編)2012

    • Author(s)
      本橋伸高
    • Publisher
      医薬ジャーナル社(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] 抗うつ薬療法と電気けいれん療法,専門医のための精神科臨床リュミエール, 25.向精神薬のリスクとベネフィット2011

    • Author(s)
      本橋伸高,樋口輝彦,石郷岡純
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] ECTの適応と課題,統合失調症治療の新たなストラテジー非定型抗精神病薬によるアプローチ2011

    • Author(s)
      本橋伸高,石郷岡純,岡崎祐士,樋口輝彦
    • Publisher
      先端医学社
    • Related Report
      2011 Final Research Report
  • [Book] 電気けいれん療法,専門医をめざす人のための精神医学改訂第3版2011

    • Author(s)
      本橋伸高,山内俊雄,小島卓也,倉知正佳,鹿島晴雄
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 今日の精神疾患治療指針(樋口輝彦他編)2011

    • Author(s)
      本橋伸高
    • Publisher
      医学書院
    • Related Report
      2011 Annual Research Report
  • [Book] 電気けいれん療法,臨床精神薬理ハンドブック第2版2009

    • Author(s)
      本橋伸高,神庭重信,大森哲郎,加藤忠史
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 非薬物的生物療法,老年期うつ病ハンドブック2009

    • Author(s)
      安田和幸,本橋伸高,三村将,仲秋秀太郎,古茶大樹
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] 電気けいれん療法(ECT),最新医学別冊,新しい診断と治療のABC9,気分障害躁うつ病改訂第2版2009

    • Author(s)
      新垣浩,本橋伸高,上島国利
    • Publisher
      最新医学社
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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