transcranial direct current stimulation : a potential treatment of depression
| Project/Area Number |
21659274
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KITAHARA Yuichi 山梨大学, 大学院・医学工学総合研究部, 助教 (00436859)
FUJII Tomokazu 山梨大学, 大学院・医学工学総合研究部, 助教 (30456454)
YASUDA Kazuyuki 山梨大学, 医学部・附属病院, 助教 (90456442)
YAMAGUCHI Masayasu 山梨大学, 医学部・附属病院, 医員 (90568263)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,970,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | 精神生理学 / うつ病 / 経頭蓋直流刺激 / 背外側前頭前野 / POMS / 認知機能 / 再認記憶 / 経頭蓋磁気刺激 / ドパミン / 近赤外線スペクトロスコピー / 脳血流 / 脳刺激 / 治療法 |
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| Research Abstract |
The effects of repeated transcranial direct current stimulation(tDCS) on mood and neurocognitive function were investigated by applying anodal stimulation over the left dorsolateral prefrontal cortex(DLPFC). We recruited healthy male participants for this single-blind, sham-controlled crossover trial. We used Profile of Mood States, brief-form(POMS) and CogHealth to evaluate the changes in mood and neurocognitive function, respectively, before, and immediately after4-daily anodal or sham tDCS. While there were no significant changes in six factors of POMS and performance(speed and accuracy) of CogHealth between sham and anodal stimulation, accuracy of a visual recognition memory task was increased at the end of experiment. Furthermore, these changes were pronounced in the group started with anodal stimulation. These results suggest that4-daily anodal tDCS over left DLPFC might improve visual recognition learning without deleterious effects in healthy subjects and further support the view that tDCS is a potential treatment of depression.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] 電気けいれん療法(ECT)のわが国での現況:全国実態調査の結果から総合病院精神科に求められること2010
Author(s)
奥村正紀, 鮫島達夫, 粟田主一, 鹿島晴雄, 本橋伸高, 澤温, 和田健, 分島徹, 川嵜弘詔, 中村満, 山口成良, 一瀬邦弘, 大久保善朗
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Journal Title
総合病院精神医学
Volume: 22
Pages: 105-118
NAID
Related Report
Peer Reviewed
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[Presentation] 気分障害の脳刺激療法2011
Author(s)
本橋伸高
Organizer
第30回躁うつ病の薬理・生化学的研究懇話会
Place of Presentation
京都ガーデンホテル(京都)(招待講演)
Year and Date
2011-07-16
Related Report
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[Presentation] ECT実態調査の報告2010
Author(s)
本橋伸高, ほか10
Organizer
第106回日本精神神経学会総会
Place of Presentation
広島国際会議場(広島)
Year and Date
2010-05-21
Related Report
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