| Project/Area Number |
21659286
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAMAI Ikumi 金沢大学, 薬学系, 教授 (20155237)
FUJIBAYASHI Yasuhisa 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, センター長 (50165411)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | ヒト培養細胞 / 機能性分子発現解析 / ポストFDG / 腫瘍診断薬 / PET製剤 / 腫瘍集積性 / アミノ酸トランスポータ / 設計戦略 |
|---|
| Research Abstract |
While searching this research for the functional biomolecule used by the database for the gene expression level of the human cultured cells for evaluation of imaging probes, and it has high-expressed to the tumor cell beforehand, the amino acid derivatives are especially taken up also in a post-FDG candidate probe, and the accumulation mechanism of the labeled amino acids which shows high affinity to the amino acid transporters to which high revelation is specifically accepted by a tumor was examined in detail, and the validity of the design strategy was evaluated from correlation with amino acid transporter gene expression and tumor accumulation of the probes.
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