Cell transplantation therapy in radiation pneumonia

• Project/Area Number: 21659295
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Tokai University
• Principal Investigator: TAMAI Yoshifumi 東海大学, 医学部, 講師 (90207225)
• Co-Investigator(Kenkyū-buntansha): FUKUYAMA Naoto 東海大学, 医学部, 准教授 (50349338)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 放射線治療学 / 脂肪由来幹細胞 / 放射線肺臓炎 / 放射線治療

Research Abstract

Radiation pneumonia is an important complications in the patients who receive radiotherapy. We examined an efficacy of the cell transplantation therapy for the radiation pneumonia in this study. Transplantation therapy using mesenchymal stem cells provided the low degree of differentiation to the lung, but the effect of treatment was obtained.

Research Products

• [Journal Article] Definitive chemoradiotherapy of limited-disease small cell lung cancer : Retrospective analysis of new predictive factors affecting treatment results (2011)
  • Author(s): Komatsu T, Oizumi Y, Kunieda E, Tamai Y, Akiba T, Kogawa A
  • Journal Title: Oncology Letters Volume: 2(5) Pages: 855-860
  • Peer Reviewed
• [Journal Article] Investigation of Bacteremia due to Aeromonas Species and Comparison with That due to Enterobacteria in Patients with Liver Cirrhosis (2011)
  • Author(s): Shizuma T, Tanaka C, Mori H, Fukuyama N
  • Journal Title: Gastroenterol Res Pract Pages: 930826-930826
  • Peer Reviewed
• [Journal Article] Therapeutic effects of four molecular-weight fractions of Kurozu against dextran sulfate sodium-induced experimental colitis (2011)
  • Author(s): Shizuma T, Nagano M, Fujii A, Mori H, Fukuyama N
  • Journal Title: Turk J Gastroenterol Volume: 22(4) Pages: 376-81
  • Peer Reviewed
• [Journal Article] Protective effects of Kurozu and Kurozu Moromimatsu on dextran sulfate sodium-induced experimental colitis (2011)
  • Author(s): Shizuma T, Ishiwata K, Nagano M, Mori H, Fukuyama N
  • Journal Title: Dig Dis Sci Volume: 56(5) Pages: 1387-92
  • Peer Reviewed
• [Journal Article] Protective effects of fermented rice vinegar sediment(Kurozu moromimatsu) in a diethylnitrosamine-induced hepatocellular carcinoma animal model (2011)
  • Author(s): Shizuma T, Ishiwata K, Nagano M, Mori H, Fukuyama N
  • Journal Title: J Clin Biochem Nutr Volume: 49(1) Pages: 31-5
  • NAID: 130004879259
  • Peer Reviewed
• [Journal Article] Local VEGF administration enhances healing of colonic anastomoses in a rabbit model (2009)
  • Author(s): Ishii M, Tanaka E, Imaizumi T, Sugio Y, Sekka T, Tanaka M, Yasuda M, Fukuyama N, Shinozaki Y, Hyodo K, Tanioka K, Mochizuki R, Kawai T, Mori H, Makuuchi H
  • Journal Title: Eur Surg Res Volume: 42(4) Pages: 249-57
  • Peer Reviewed
• [Presentation] 機能性食品の発展性肝虚血後再灌流動物モデルにおけるケルセチンの効果 (2012)
  • Author(s): 静間徹, 石渡一夫, 福山直人
  • Organizer: 第27回日本静脈経腸栄養学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-02-23
• [Presentation] 2型糖尿病モデルラットにおける頭蓋内微小動脈の血管反応性についての検討 (2011)
  • Author(s): 塚本祐子, 瀧澤俊也, 福山直人, 小原さおり, 清水美沙, 高張洋子, 永田栄一郎, 高木繁治
  • Organizer: 第23回日本脳循環代謝学会総会、都市センターホテル
  • Place of Presentation: 東京都
  • Year and Date: 2011-11-05
• [Presentation] 消化器疾患におけるprobioticsと機能性食品の有用性DEN誘発性肝細胞癌動物モデルを用いた、黒酢もろみ末の抗腫瘍効果と機序の解明 (2011)
  • Author(s): 静間徹, 吉野肇一, 福山直人
  • Organizer: 第53回日本消化器病学会大会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2011-10-21
• [Presentation] 黒酢もろみ末における抗腫瘍効果VEGFタンパク発現の抑制 (2011)
  • Author(s): 福山直人, 静間徹, 石渡一夫, 長野正信, 盛英三
  • Organizer: 第48回日本外科代謝栄養学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-07-08
• [Presentation] DSS誘発性大腸炎動物モデルを用いた、黒酢の抗大腸炎効果 (2011)
  • Author(s): 静間徹, 石渡一夫, 福山直人
  • Organizer: 第48回日本外科代謝栄養学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-07-07