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Development of newly-designed molecular targeted diagnostic PET study using system A amino acid tracer

Research Project

Project/Area Number 21659297
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionResearch Institute, Shiga Medical Center

Principal Investigator

HIGASHI Tatsuya  滋賀県立成人病センター(研究所), 画像研究部門, 総括研究員 (50324629)

Co-Investigator(Kenkyū-buntansha) NISHII Ryuichi  宮崎大学, 医学部, 講師 (60463212)
KAGAWA Shinya  滋賀県立成人病センター(研究所), 画像研究部門, 主任研究員 (10393191)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsアミノ酸輸送システム / PET検査 / 脳腫瘍 / 胸部腫瘍 / 前立腺腫瘍
Research Abstract

In order to overcome the drawback of false positive diagnosis at FDG-PET in the patients with inflammatory diseases, we have developed[N-methyl-^<11> C] MeAIB, an artificial system A amino acid PET tracer, confirmed its safety at animal and human study, established its sophisticated synthesis methods, and established its basic procedure at clinical oncologic human study. We have finished more than 200 cases of patients with various tumors including brain tumors, chest cancers, and prostate cancers, and MeAIB-PET has shown its valuable clinical role in the differential diagnosis between cancers and inflammatory diseases.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2012 2011 2010 2009 Other

All Presentation (17 results) Remarks (8 results)

  • [Presentation] Assessment of efficacy of[^<11> C]-MeAIB PET/CT as a biomarker of the system A amino acid transport : Comparison with[^<18> F]-FDG and MRI in the patients with prostate cancer2012

    • Author(s)
      Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa
    • Organizer
      59th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      Miami, USA
    • Year and Date
      2012-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる縦隔腫瘍PET診断2012

    • Author(s)
      東達也、西井龍一、加川信也
    • Organizer
      第4回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      プラザ淡海、滋賀
    • Year and Date
      2012-02-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる縦隔腫瘍PET診断2012

    • Author(s)
      東達也, 他
    • Organizer
      第4回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      大津市、滋賀県
    • Year and Date
      2012-02-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる前立腺癌PET診断-FDG、 MRIとの比較検討による中間報告-2011

    • Author(s)
      東達也、西井龍一、加川信也
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場、埼玉
    • Year and Date
      2011-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる前立腺癌PET診断2011

    • Author(s)
      東達也, 他
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば市、茨城県
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Usefulness of Double Tracer PET study using[^<18> F] FDG and Amino Acid Radiotracer,[^<11> C] MeAIB, in the Diagnosis of Mediastinal Diseases2011

    • Author(s)
      Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa
    • Organizer
      58th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2011-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 縦隔腫瘍診断におけるアミノ酸PET製剤MeAIBの有用性2011

    • Author(s)
      東達也, 他
    • Organizer
      第58回米国核医学会総会
    • Place of Presentation
      米国サンアントニオ
    • Year and Date
      2011-06-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 悪性リンパ腫ステージングにおける新規アミノ酸PET製剤MeAIBの臨床応用2011

    • Author(s)
      東達也、西井龍一、加川信也
    • Organizer
      第24回京滋臨床血液研究会
    • Place of Presentation
      シェラトン都ホテル京都、京都
    • Year and Date
      2011-02-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる胸部腫瘍PET診断2010

    • Author(s)
      東達也、西井龍一、加川信也
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮ソニックシティ、埼玉
    • Year and Date
      2010-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] アミノ酸ポジトロン製剤MeAIBを用いた胸部腫瘍PET診断の初期経験2010

    • Author(s)
      東達也、西井龍一、加川信也
    • Organizer
      第43回日本核医学会近畿地方会
    • Place of Presentation
      大阪、国際交流センター
    • Year and Date
      2010-07-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Usefulness of New Amino Acid Radiotracer,[^<11> C] MeAIB, in the Oncologic PET Diagnosis of Chest Malignancies2010

    • Author(s)
      Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa
    • Organizer
      57th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2010-06-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Other promising tracers--overview of Japanese situation.2010

    • Author(s)
      東達也
    • Organizer
      57th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] New Amino Acid Radiotracer, [^<11>C]MeAIB, in the Oncologic PET Diagnosis of Chest Malignancies.2010

    • Author(s)
      東達也
    • Organizer
      57th Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる胸部腫瘍PET診断2010

    • Author(s)
      東達也
    • Organizer
      第2回呼吸機能イメージング研究会
    • Place of Presentation
      那覇、沖縄県
    • Year and Date
      2010-01-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる胸部腫瘍PET診断2010

    • Author(s)
      東達也、西井龍一、加川信也
    • Organizer
      第2回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      沖縄コンベンションセンター、沖縄
    • Year and Date
      2010-01-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳腫瘍に対するPET検査-MeAIB, Methionine, FDG三核種による画像比較の初期経験2009

    • Author(s)
      東達也、西井龍一、加川信也
    • Organizer
      第49回日本核医学会総会
    • Place of Presentation
      旭川市民文化会館、北海道
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳腫瘍に対するPET検査-MeAIB,Methionine,FDG三核種による画像比較の初期経験2009

    • Author(s)
      東達也
    • Organizer
      第49回日本核医学会 総会
    • Place of Presentation
      旭川、北海道
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.shigamed.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks] 学会賞など受賞歴(1)平成24年2月11日第4回呼吸機能イメージング研究会優秀演題賞受賞

    • Related Report
      2011 Final Research Report
  • [Remarks] (2)平成23年6月7日The 58th Society of Nuclear Medicine(SNM) Annual Meeting, San Antonio, US, June, 2011.Poster Award finalist.(優秀論文賞)(Oncology-Clinical Diagnostic Track(臨床腫瘍研究部門))

    • Related Report
      2011 Final Research Report
  • [Remarks] (3)平成22年6月7日The 57th Society of Nuclear Medicine(SNM) Annual Meeting, Salt Lake City, US, June, 2010.First Place Poster Award(最優秀論文賞)(Oncology-Clinical Diagnostic Track(臨床腫瘍研究部門))

    • Related Report
      2011 Final Research Report
  • [Remarks] (4)平成22年1月31日第2回呼吸機能イメージング研究会優秀演題賞受賞

    • Related Report
      2011 Final Research Report
  • [Remarks] 受賞歴等平成23年06月07日The 58th Society of Nuclear Medicine (SNM) Annual Meeting, San Antonio, US.First Place Poster賞(最優秀論文賞)(Oncology-Clinical Diagnostic Track(臨床腫瘍研究部門)),finalist(4-10位).平成24年02月11日第4回呼吸機能イメージング研究会優秀演題賞受賞

    • Related Report
      2011 Annual Research Report
  • [Remarks] 平成22年06月07日 The 57th Society of Nuclear Medicine (SNM) Annual Meeting, Salt Lake City, US, June, 2010.First Place Poster賞(最優秀論文賞)(Oncology-Clinical Diagnostic Track(臨床腫瘍研究部門))

    • Related Report
      2010 Annual Research Report
  • [Remarks] 平成22年1月31日第2回呼吸機能イメージング研究会優秀演題賞受賞

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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