Development of Novel Therapeutic Angiogenesis Method by Combination of Nanotechnology and siRNA Targeting PHD2

• Project/Area Number: 21659299
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: The University of Tokyo
• Principal Investigator: NISHIYAMA Nobuhiro 東京大学, 大学院・医学系研究科, 准教授 (10372385)
• Co-Investigator(Kenkyū-buntansha): ITAKA Keiji 東京大学, 大学院・医学系研究科, 特任准教授 (60292926)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: ドラッグデリバリー / siRNA / 遺伝子治療 / 虚血性疾患 / 血管再生

Research Abstract

To establish the effective strategy for therapeutic angiogenesis of ischemic diseases, in this project, we revealed the efficacy of siRNA-mediated knockdown of PHD2, which lead to enhanced expression of angiogenic factors regulated by HIF-1α, in a mouse ischemic limb model. For this purpose, we also developed polymeric nanocarriers for in vivo delivery of plasmid DNA and siRNA.

Research Products

• [Journal Article] Rational design of smart supramolecular assemblies for gene delivery : Chemical challenges in the creation of artificial viruses (2012)
  • Author(s): K. Miyata, N. Nishiyama, K. Kataoka
  • Journal Title: Chem. Soc. Rev Volume: 41(7) Issue: 7 Pages: 2562-2574
  • DOI: 10.1039/c1cs15258k
  • Peer Reviewed
• [Journal Article] Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain (2012)
  • Author(s): T.Suma, N.Nishiyama, et al
  • Journal Title: Biomaterials Volume: 33 Issue: 9 Pages: 2770-2779
  • DOI: 10.1016/j.biomaterials.2011.12.022
  • Peer Reviewed
• [Journal Article] Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination (2012)
  • Author(s): M.Kumagai, N.Nishiyama, et al.
  • Journal Title: J.Control.Release Volume: (in press)(印刷中)(掲載確定) Issue: 3 Pages: 542-551
  • DOI: 10.1016/j.jconrel.2012.03.021
  • Peer Reviewed
• [Journal Article] Polymeric micelles incorporating (1,2-diaminocyclohexane) platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis (2012)
  • Author(s): Md Rafi, N.Nishiyama, et al.
  • Journal Title: J.Control.Release Volume: (in press)(印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Evaluation of intracellular trafficking and clearance from HeLa cells of doxorubic in-bound block copolymers (2012)
  • Author(s): K.Sakai-Kato, N.Nishiyama, et al.
  • Journal Title: Int.J.Pharm. Volume: 423 Issue: 2 Pages: 401-409
  • DOI: 10.1016/j.ijpharm.2011.12.022
  • Peer Reviewed
• [Journal Article] Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs (2012)
  • Author(s): M.Baba, N.Nishiyama, et al.
  • Journal Title: J.Control.Release Volume: 157 Issue: 1 Pages: 112-117
  • DOI: 10.1016/j.jconrel.2011.07.026
  • Peer Reviewed
• [Journal Article] Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo (2011)
  • Author(s): A. Iriyama, M. Oba, T. Ishii, N. Nishiyama, K. Kataoka, Y. Tamaki, Y. Yanagi
  • Journal Title: PLoS One Volume: 6(12) Issue: 12 Pages: e28560-e28560
  • DOI: 10.1371/journal.pone.0028560
  • Peer Reviewed
• [Journal Article] Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo (2011)
  • Author(s): A. Iriyama, T. Usui, Y. Yanagi, S. Amano, M. Oba, K. Miyata, N. Nishiyama, K. Kataoka
  • Journal Title: Cornea Volume: 30(12) Issue: 12 Pages: 1423-1427
  • DOI: 10.1097/ico.0b013e318206c893
  • Peer Reviewed
• [Journal Article] PEG-detachable cationic polyaspartamide detivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor (2011)
  • Author(s): H.-J.Kim, N.Nishiyama, et al
  • Journal Title: J.Drug Target. Volume: 20 Issue: 1 Pages: 33-42
  • DOI: 10.3109/1061186x.2011.632010
  • Peer Reviewed
• [Journal Article] Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size (2011)
  • Author(s): H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka
  • Journal Title: Nature Nanotech Volume: 6(12) Issue: 12 Pages: 815-823
  • DOI: 10.1038/nnano.2011.166
  • Peer Reviewed
• [Journal Article] Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging (2011)
  • Author(s): F.M.Konig, Y.Vachutinsky, M.Oba, K.Miyata, N.Nishiyama, K.Kataoka, C.Brauchle, N.Ruthardt
  • Journal Title: Journal of Controlled Release Volume: 151(2) Issue: 3 Pages: 104-109
  • DOI: 10.1016/j.jconrel.2011.08.003
  • Peer Reviewed
• [Journal Article] Supramolecular nanodevices : From design validation to theranostic nanomedicine. Acc (2011)
  • Author(s): H. Cabral, N. Nishiyama, K. Kataoka
  • Journal Title: Chem. Res Volume: 44(10) Issue: 10 Pages: 999-1008
  • DOI: 10.1021/ar200094a
  • Peer Reviewed
• [Journal Article] Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles (2011)
  • Author(s): H.Uchida, N.Nishiyama, et al
  • Journal Title: J.Am.Chem.Soc. Volume: 133 Issue: 39 Pages: 15524-15532
  • DOI: 10.1021/ja204466y
  • Peer Reviewed
• [Journal Article] Effect of polymer structure on micelles formed between siRNA and cationic block copolymer Comprising thiols and amidines (2011)
  • Author(s): R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T.-C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka
  • Journal Title: Biomacromolecules Volume: 12(9) Issue: 9 Pages: 3174-3185
  • DOI: 10.1021/bm2006714
  • Peer Reviewed
• [Journal Article] Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity (2011)
  • Author(s): F. Pittella, M. Zhang, Y. Lee, H.-J. Kim, T. Tockary, K. Osada, T. Ishii, K. Miyata, N. Nishiyama
  • Journal Title: Biomaterials Volume: 32(11) Issue: 11 Pages: 3106-3114
  • DOI: 10.1016/j.biomaterials.2010.12.057
  • Peer Reviewed
• [Journal Article] Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles (2011)
  • Author(s): Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M. R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka
  • Journal Title: J. Control. Release Volume: 149(1) Issue: 1 Pages: 51-57
  • DOI: 10.1016/j.jconrel.2010.02.002
  • Peer Reviewed
• [Journal Article] Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting (2011)
  • Author(s): M. Murakami, H. Cabral, Y. Matsumoto, S. Wu, M. R. Kano, T. Yamori, N. Nishiyama, K. Kataoka
  • Journal Title: Science Transl. Med Volume: 3(64) Issue: 64 Pages: 64-64
  • DOI: 10.1126/scitranslmed.3001385
  • Peer Reviewed
• [Journal Article] Polylex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery (2011)
  • Author(s): M.Oba, K.Miyata, K.Osada, R.J.Christie, M.Sanjoh, W.Li, S.Fukushima, T.Ishii, M.R.Kano, N.Nishiyama, H.Koyama, K.Kataoka
  • Journal Title: Biomaterials Volume: 32(2) Issue: 2 Pages: 652-663
  • DOI: 10.1016/j.biomaterials.2010.09.022
  • Peer Reviewed
• [Journal Article] Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy (2011)
  • Author(s): S.Herlambang, N.Nishiyama, et al.
  • Journal Title: J.Control.Release Volume: 155 Issue: 3 Pages: 449-457
  • DOI: 10.1016/j.jconrel.2011.06.019
  • Peer Reviewed
• [Journal Article] In situ quantitative monitoring of polyplexes and polyplex Micelles in the blood circulation using intravital real-time confocal laser scanning microscopy (2011)
  • Author(s): T.Nomoto, Y.Matsumoto, K.Miyata, M.Oba, S.Fukushima, N.Nishiyama, T.Yamasoba, K.Kataoka
  • Journal Title: J.Control.Release Volume: 151(2) Issue: 2 Pages: 104-109
  • DOI: 10.1016/j.jconrel.2011.02.011
  • Peer Reviewed
• [Journal Article] Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. (2011)
  • Author(s): Y.Vachutinsky, N.Nishiyama, et al.
  • Journal Title: J.Control.Release Volume: 149 Pages: 51-57
  • Peer Reviewed
• [Journal Article] Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. (2011)
  • Author(s): M.Murakami, N.Nishiyama, et al.
  • Journal Title: Science Transl.Med. Volume: 3
  • Peer Reviewed
• [Journal Article] Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. (2011)
  • Author(s): M.Oba, N.Nishiyama, et al.
  • Journal Title: Biomaterials Volume: 32 Pages: 652-663
  • Peer Reviewed
• [Journal Article] Visible-drug delivery by supra-molecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model (2010)
  • Author(s): S. Kaida, H. Cabral, M. Kumagai, A. Kishimura, Y. Terada, M. Sekino, I. Aoki, N. Nishiyama, T. Tani, K. Kataoka
  • Journal Title: Cancer Res Volume: 70(18) Issue: 18 Pages: 7031-7041
  • DOI: 10.1158/0008-5472.can-10-0303
  • Peer Reviewed
• [Journal Article] siRNA-grafted polymer for polyion complex(PIC)-based siRNA delivery : Enhancement of PIC stability and gene silencing efficiency (2010)
  • Author(s): H. Takemoto, A. Ishii, K. Miyata, M. Nakanishi, M. Oba, T. Ishii, Y. Yamasaki, N. Nishiyama, K. Kataoka
  • Journal Title: Biomaterials Volume: 31(31) Issue: 31 Pages: 8097-8105
  • DOI: 10.1016/j.biomaterials.2010.07.015
  • Peer Reviewed
• [Journal Article] Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown (2010)
  • Author(s): H.-J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, M. Oba, N. Nishiyama, K. Kataoka
  • Journal Title: J. Control. Release Volume: 145(2) Issue: 2 Pages: 141-148
  • DOI: 10.1016/j.jconrel.2010.03.019
  • Peer Reviewed
• [Journal Article] Enhanced transfection with silica-coated polyplexes loading plasmid DNA (2010)
  • Author(s): K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y. Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka
  • Journal Title: Biomaterials Volume: 31(17) Issue: 17 Pages: 4764-4770
  • DOI: 10.1016/j.biomaterials.2010.02.033
  • Peer Reviewed
• [Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1 (2010)
  • Author(s): M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka
  • Journal Title: Mol. Pharm Volume: 7(2) Issue: 2 Pages: 501-509
  • DOI: 10.1021/mp9002317
  • Peer Reviewed
• [Journal Article] siRNA-based therapy ameliorates glomerulonephritis (2010)
  • Author(s): H. Shimizu, Y. Hori, S. Kaname, K. Yamada, N. Nishiyama, S. Matsumoto, K. Miyata, M. Oba, A. Yamada, K. Kataoka, T. Fujita
  • Journal Title: J. Am. Soc. Nephrol Volume: 21(4) Issue: 4 Pages: 622-633
  • DOI: 10.1681/asn.2009030295
  • Peer Reviewed
• [Journal Article] Efficient delivery of bioactive antibodies into thecytoplasm of living cells by charge-conversional polyion complex micelles. Angew (2010)
  • Author(s): Y. Lee, T. Ishii, H.-J. Kim, N. Nishiyama, Y. Hayakawa, K. Itaka, K. Kataoka
  • Journal Title: Chem. Int. Ed Volume: 49(14) Issue: 14 Pages: 2552-2555
  • DOI: 10.1002/anie.200905264
  • Peer Reviewed
• [Journal Article] Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. (2010)
  • Author(s): Y.Matsumoto, N.Nishiyama, et al.
  • Journal Title: Biomed.Opt.Express Volume: 1 Pages: 1209-1216
  • Peer Reviewed
• [Journal Article] Visible-drug delivery by supra-molecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model. (2010)
  • Author(s): S.Kaida, N.Nishiyama, et al.
  • Journal Title: Cancer Research Volume: 70 Pages: 7031-7041
  • Peer Reviewed
• [Journal Article] Enhanced In vivo magnetic resonance imaging of tumors by PEGylatediron oxide-gold core-shell nanoparticles with prolonged blood circulation properties. (2010)
  • Author(s): M.Kumagai, N.Nishiyama, et al.
  • Journal Title: Macromol.Rapid Commun. Volume: 31 Pages: 1521-1528
  • Peer Reviewed
• [Journal Article] siRNA-grafted polymer for polyion complex (PIC)-based siRNA delivery : Enhancement of PIC stability and gene silencing efficiency. (2010)
  • Author(s): H.Takemoto, N.Nishiyama, et al.
  • Journal Title: Biomaterials Volume: 31 Pages: 8097-8105
  • Peer Reviewed
• [Journal Article] Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. (2010)
  • Author(s): H.-J.Kim, N.Nishiyama, et al.
  • Journal Title: J.Control.Release Volume: 145 Pages: 141-148
  • Peer Reviewed
• [Journal Article] Enhanced transfection with silica-coated polyplexes loading plasmid DNA. (2010)
  • Author(s): K.Miyata, N.Nishiyama, et al.
  • Journal Title: Biomaterials Volume: 31 Pages: 4764-4770
  • Peer Reviewed
• [Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1 (2010)
  • Author(s): M.Oba, N.Nishiyama, et al.
  • Journal Title: Molecular Pharmaceutics (in press, (印刷中)掲載確定)
  • Peer Reviewed
• [Journal Article] Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. (2010)
  • Author(s): Y.Vachutinsky, N.Nishiyama, et al.
  • Journal Title: J.Control.Release (in press, (印刷中)掲載確定)
  • Peer Reviewed
• [Journal Article] Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles. (2010)
  • Author(s): Y.Lee, N.Nishiyama, et al.
  • Journal Title: Angew.Chem.Int.Ed. 49 Pages: 2552-2555
  • Peer Reviewed
• [Journal Article] Enhanced transfection with silica-coated polyplexes loading plasmid DNA. (2010)
  • Author(s): K.Miyata, N.Nishiyama, et al.
  • Journal Title: Biomaterials 31 Pages: 4764-4770
  • Peer Reviewed
• [Journal Article] Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles (2009)
  • Author(s): M. Han, M. Oba, N. Nishiyama, M. R. Kano, S. Kizaka-Kondoh, K. Kataoka
  • Journal Title: Mol. Ther Volume: 17(8) Issue: 8 Pages: 1404-1410
  • DOI: 10.1038/mt.2009.119
  • Peer Reviewed
• [Journal Article] Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats (2009)
  • Author(s): M. Harada-Shiba, I. Takamisawa, K. Miyata, T. Ishii, N. Nishiyama, K. Itaka, K. Kangawa, F. Yoshihara, Y. Asada, K. Hatakeyama, N. Nagaya, K. Kataoka
  • Journal Title: Mol. Ther Volume: 17(7) Issue: 7 Pages: 1180-1186
  • DOI: 10.1038/mt.2009.63
  • Peer Reviewed
• [Journal Article] PEGylated calcium phosphate nanocomposites as smart environment-sensitive carriers for siRNA delivery (2009)
  • Author(s): M. Zhang, A. Ishii, N. Nishiyama, S. Matsumoto, T. Ishii, Y. Yamasaki, K. Kataoka
  • Journal Title: Adv. Mater Volume: 21(34) Issue: 34 Pages: 3520-3525
  • DOI: 10.1002/adma.200800448
  • Peer Reviewed
• [Journal Article] Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm (2009)
  • Author(s): Y. Lee, T. Ishii, H. Cabral, H.-J. Kim, J.-H. Seo, N. Nishiyama, H. Oshima, K. Osada, K. Kataoka
  • Journal Title: Angew. Chem. Int. Ed Volume: 48(29) Issue: 29 Pages: 5309-5312
  • DOI: 10.1002/anie.200900064
  • Peer Reviewed
• [Journal Article] Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery (2009)
  • Author(s): S. Matsumoto, R. J. Christie, N. Nishiyama, K. Miyata, A. Ishii, M. Oba, H. Koyama, Y. Yamasaki, K. Kataoka
  • Journal Title: Biomacromolecules Volume: 10(1) Issue: 1 Pages: 119-127
  • DOI: 10.1021/bm800985e
  • Peer Reviewed
• [Journal Article] Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block-copolymer-coated magnetite nanoparticles combined with TGF-beta inhibitor. (2009)
  • Author(s): M.Kumagai, N.Nishiyama, et al.
  • Journal Title: J.Control.Release 140 Pages: 306-311
  • Peer Reviewed
• [Journal Article] Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles. (2009)
  • Author(s): M.Han, N.Nishiyama, et al.
  • Journal Title: Angew.Chem.Int.Ed. 17 Pages: 1404-1410
  • Peer Reviewed
• [Journal Article] Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. (2009)
  • Author(s): M.Harada-Shiba, N.Nishiyama, et al.
  • Journal Title: Molecular Ther. 17 Pages: 1180-1186
  • Peer Reviewed
• [Journal Article] PEGylated calcium phosphate nanocomposites as smart environment-sensitive carriers for siRNA delivery (2009)
  • Author(s): M.Zhang, N.Nishiyama, et al.
  • Journal Title: Advanced Materials 21 Pages: 3520-3525
  • Peer Reviewed
• [Presentation] ナノスケールのトロイの木馬として機能する高分子ミセルによる薬剤耐性の克服 (2011)
  • Author(s): 西山伸宏
  • Organizer: 第13回図書館総合展フォーラム
  • Place of Presentation: パシフィコ横浜(神奈川県、横浜市)(招待講演)
  • Year and Date: 2011-11-10
• [Presentation] Development of polymeric micelles for innovative cancer diagnosis and treatment (2011)
  • Author(s): 西山伸宏
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県,名古屋市)(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] Development of functional polymeric micelles for cancer diagnosis and therapy (2011)
  • Author(s): 西山伸宏
  • Organizer: The 14th Asian Chemical Congress
  • Place of Presentation: Queen Sirikit National Convention Center(タイ,バンコク)(招待講演)
  • Year and Date: 2011-09-08
• [Presentation] Development of functional polymeric micelles for cancer diagnosis and therapy (2011)
  • Author(s): N. Nishiyama
  • Organizer: Singapore-Japan "Bioelectronics" Workshop
  • Place of Presentation: Keihanna plaza, Kyoto, Japan
  • Year and Date: 2011-08-12
• [Presentation] Development of functional polymeric micelles for cancer diagnosis and therapy (2011)
  • Author(s): 西山伸宏
  • Organizer: Singapore-Japan "Bioelectronics" Workshop
  • Place of Presentation: けいはんなプラザ(京都府,相楽郡)(招待講演)
  • Year and Date: 2011-08-12
• [Presentation] 高分子集合体を利用したターゲティング型DDSの開発 (2011)
  • Author(s): 西山伸宏
  • Organizer: 第24回インターフェックスジャパン
  • Place of Presentation: 東京ビッグサイト(東京都江東区)(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] Development of photosensitizer drug delivery system for cancer theranostics (2011)
  • Author(s): N. Nishiyama
  • Organizer: 28th International Conference of Photopolymer Science and Technology
  • Place of Presentation: University Convention Hall, Chiba University, Chiba
  • Year and Date: 2011-06-24
• [Presentation] Design of smart nanocarriers for photosensitizer delivery (2011)
  • Author(s): N. Nishiyama, K. Kataoka
  • Organizer: 13^<th> World Congress of International Photodynamic Association(IPA)
  • Place of Presentation: Innsbruck, Austria
  • Year and Date: 2011-05-12
• [Presentation] Design of smart nanocarriers for photosensitizer delivery (2011)
  • Author(s): 西山伸宏
  • Organizer: 13^<th> World Congress of International Photodynamic Association (IPA)
  • Place of Presentation: Innsbruck Convention Center(Innsbruck,オーストリア)(招待講演)
  • Year and Date: 2011-05-12
• [Presentation] Development of functional polymeric micelles for cancer diagnosis and therapy (2011)
  • Author(s): N. Nishiyama
  • Organizer: 2011 International Symposium on Intelligent Drug Delivery Systems
  • Place of Presentation: KIST, Seoul, Korea, April
  • Year and Date: 2011-04-28
• [Presentation] Development of functional polymeric micelles for cancer diagnosis and therapy (2011)
  • Author(s): 西山伸宏
  • Organizer: 2011 International Symposium on Intelligent Drug Delivery Systems
  • Place of Presentation: KIST(ソウル市,韓国)(招待講演)
  • Year and Date: 2011-04-28
• [Presentation] Development of functional polymeric micelles for cancer diagnosis and therapy (2011)
  • Author(s): N. Nishiyama
  • Organizer: The 14th Asian Chemical Congress(14-ACC)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Polymeric micelles for photodynamic diagnosis and therapy (2011)
  • Author(s): N. Nishiyama, Y. Morimoto, K. Kataoka
  • Organizer: The 15th International Symposium on Recent Advances in Drug Delivery Systems
  • Place of Presentation: Sheraton Hotel, Salt Lake City, Utah, USA
• [Presentation] オキサリプラチン耐性克服のための細胞内環境応答型高分子ミセルの開発 (2010)
  • Author(s): 西山伸宏, 他5名
  • Organizer: 第32回日本バイオマテリアル学会
  • Place of Presentation: グランドプリンスホテル広島,広島
  • Year and Date: 2010-11-30
• [Presentation] 高分子ミセル型DDSと光照射システムの融合による革新的PDT (2010)
  • Author(s): 西山伸宏, 他2名
  • Organizer: 第31回日本レーザー医学会総会
  • Place of Presentation: ウインクあいち,愛知
  • Year and Date: 2010-11-13
• [Presentation] Nanocarrier-mediated photodynamic diagnosis and therapy of malignant tumors, New Directions In Nanotheranostics : Imaging, Biosensors, Materials and DNA Technologies (2010)
  • Author(s): N. Nishiyama, Y. Morimoto, K. Kataoka
  • Organizer: 4^<th> Annual Symposium on Nanobiotechnology
  • Place of Presentation: Ludwig-Maximilians University, Munich, Germany
  • Year and Date: 2010-10-06
• [Presentation] Nanocarrier-mediated photodynamic diagnosis and therapy of malignant tumors (2010)
  • Author(s): N.Nishiyama, et al.
  • Organizer: 4^<th> Annual Symposium on Nanobiotechnology "New Direciions In Nanotheranostics : Imaging, Biosensors, Materials and DNA Technologies"
  • Place of Presentation: Ludwig-Maximilians University, Munich, Germany
  • Year and Date: 2010-10-06
• [Presentation] Development of smart polymeric micelles for innovative cancer therapy (2010)
  • Author(s): N. Nishiyama, H. Cabral, K. Kataoka
  • Organizer: World Congress of Pharmacy and Pharmaceutical Sciences
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2010-09-01
• [Presentation] 高分子ミセルを利用した細胞内薬物分布の時空間制御に基づく耐性がんの克服 (2010)
  • Author(s): 西山伸宏, 他4名
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪国際交流センター,大阪
  • Year and Date: 2010-06-18
• [Presentation] 細胞内環境に応答する白金錯体制がん剤内包高分子ミセルの創製 (2010)
  • Author(s): 西山伸宏, 他4名
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜,神奈川
  • Year and Date: 2010-05-27
• [Presentation] 光線力学治療のための光増感剤内包高分子ミセルの開発 (2010)
  • Author(s): 西山伸宏
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: ホテルグランヴィア,岡山
  • Year and Date: 2010-03-29
• [Presentation] Development of polymeric micelles for photodynamic diagnosis and treatment of solid tumors (2010)
  • Author(s): N.Nishiyama, et al.
  • Organizer: Symposium on Biomedical Polymers for Drug Delivery
  • Place of Presentation: University of Utah, USA
  • Year and Date: 2010-03-26
• [Presentation] 高機能ポリマー材料を基盤とした遺伝子デリバリーシステムの設計 (2009)
  • Author(s): 西山伸宏, 他5名
  • Organizer: 第18回ポリマー材料フォーラム研究会
  • Place of Presentation: タワーホール船堀,東京
  • Year and Date: 2009-11-24
• [Presentation] Development of polymeric micelles for innovative cancer therapy (2009)
  • Author(s): 西山伸宏
  • Organizer: 第68回日本癌学会
  • Place of Presentation: パシフィコ横浜,神奈川
  • Year and Date: 2009-10-02
• [Presentation] がん深部への遺伝子・薬剤デリバリーのためのナノキャリアの設計 (2009)
  • Author(s): 西山伸宏, 他6名
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学黒髪キャンパス,熊本
  • Year and Date: 2009-09-17
• [Presentation] Block copolymer micelles as smart supramolecular nanodevices for tumor targeting (2009)
  • Author(s): N. Nishiyama
  • Organizer: The 36th Annual Meeting and Exposition of the Controlled Release Society
  • Place of Presentation: Bella Center, Copenhagen Denmark
  • Year and Date: 2009-07-19
• [Presentation] Block copolymer micelles as smart supramolecular nanodevices for tum or targeting (2009)
  • Author(s): N.Nishiyama
  • Organizer: The 36th Annual Meeting and Exposition of the Controlled Release Society
  • Place of Presentation: Bella Center,コベンハーゲン、デンマーク
  • Year and Date: 2009-07-19
• [Presentation] Development of dendirimer phthalocyanine-loaded polymericmicelles for diagnosis and treatment of microcarcinoma (2009)
  • Author(s): N. Nishiyama, Y. Morimoto, K. Miyazaki, K. Urano, S. Horie, M. Kumagai, S. Fukushima, W.-D. Jang, K. Kataoka
  • Organizer: The 36th Annual Meeting and Exposition of the Controlled Release Society
  • Place of Presentation: Bella Center, Copenhagen Denmark
  • Year and Date: 2009-07-12
• [Presentation] Development of dendrimer phthalocyanine-loaded polymeric micelle for detection and treatment of microcarcinoma (2009)
  • Author(s): N.Nishiyama, et al.
  • Organizer: 8th International Symposium on Frontiers in Biomedical Polymers(FBPS09)
  • Place of Presentation: 東レ研修センター、三島、静岡
  • Year and Date: 2009-05-22
• [Remarks]
  • URL: http://www.bmw.t.u-tokyo.ac.jp/
• [Patent(Industrial Property Rights)] 核酸送達用組成物及び担体組成物、それを用いた医薬組成物、並びに核酸送達方法 (2010)
  • Inventor(s): 片岡一則,フレデリコピテラシルバ,ミンゼンジャン,西山伸宏,宮田完二郎,ヤンイー
  • Industrial Property Rights Holder: 国立大学法人,東京大学
  • Industrial Property Number: 2010-102880
  • Filing Date: 2010-04-28
• [Patent(Industrial Property Rights)] Size Controlled Micelle of Plutinum Coordination Complex (2009)
  • Inventor(s): 西山伸宏, 片岡一則, 他2名
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2009-07-16
  • Overseas