| Project/Area Number |
21659299
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITAKA Keiji 東京大学, 大学院・医学系研究科, 特任准教授 (60292926)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | ドラッグデリバリー / siRNA / 遺伝子治療 / 虚血性疾患 / 血管再生 |
|---|
| Research Abstract |
To establish the effective strategy for therapeutic angiogenesis of ischemic diseases, in this project, we revealed the efficacy of siRNA-mediated knockdown of PHD2, which lead to enhanced expression of angiogenic factors regulated by HIF-1α, in a mouse ischemic limb model. For this purpose, we also developed polymeric nanocarriers for in vivo delivery of plasmid DNA and siRNA.
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