| Project/Area Number |
21659337
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505)
NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284)
YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,430,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2009: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | 中性子捕捉療法 / ホウ素中性子捕捉療法 / 抗酸化作用 / ホウ素化合物 / グルタチオン |
|---|
| Research Abstract |
We synthesize novel peptide which consist of boronated amino-acid. We succeed the synthesis pentamer and decamer of bolonophenylalanine by fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis. And we developed novel lipopeptide which containing boron, and liposome with it. We found the pre-treatment of glutathione modified the in vivo distribution of boron compounds.
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