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Elucidating the bone resorption mechanism using a glycobiological approach

Research Project

Project/Area Number 21659346
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

IWASAKI Norimasa  北海道大学, 大学院・医学研究科, 准教授 (30322803)

Co-Investigator(Kenkyū-buntansha) ABE Yuichirou  北海道大学, 北海道大学病院, 助教 (80547604)
高畑 雅彦  北海道大学, 大学病院, 助教 (40374368)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2009: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords骨吸収 / 破骨細胞 / 糖鎖 / ガングリオシド / 脂質ラフト / 糖脂質 / 糖鎖受容体 / レクチン / 細胞融合 / RANKL / シアリル糖鎖 / 骨代謝 / 糖蛋白質
Research Abstract

We established expression profiles of N-linked glycans and glycosphingolipids during osteoclastogenesis. Among glycosphingolipids expressed on osteoclasts and these precursor cells, we identified GD1/ganglioside as a negative regulator of proliferation of osteoclast precursor cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2012 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Threshold in stage specific embryonic glycotype uncovered by a full portrait of dynamic N-glycan expression during cell differentiation.2010

    • Author(s)
      Amano M, Iwasaki N, et al.
    • Journal Title

      Mol Cell Proteomics

      Volume: 9 Pages: 523-537

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] A Member of Sialic Acid-Binding Immunoglobulin-Like lectin 15(Siglec-15) Associates with DAP12-mediated Costimulatory Signal in Osteoclastogenesis2012

    • Author(s)
      Miki Komatsu, Masahiko Takahata, Norimasa Iwasaki.
    • Organizer
      The orthopaedic Research Society(ORS) annual meeting 2012
    • Place of Presentation
      米国: Moscone West Convention Center
    • Related Report
      2011 Final Research Report
  • [Presentation] 脂質ラフトを介した骨芽細胞増殖刺激調節機構の解明2009

    • Author(s)
      安倍雄一郎, 岩崎倫政, 他
    • Organizer
      第24回北海道日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂質ラフトを介した骨芽細胞増殖刺激調節機構の解明2009

    • Author(s)
      安倍雄一郎, 岩崎倫政, 他
    • Organizer
      第117回北海道整形災害外科学会
    • Place of Presentation
      小樽
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫グロブリン様レクチンSiglec-15はDAP12を介した共刺激シグナルに関与し破骨細胞分化を制御する

    • Author(s)
      小松幹,高畑雅彦,岩崎倫政
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪市:大阪国際会議場
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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