Molecular control of chondrovytes in the growth plate

• Project/Area Number: 21659354
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokushima
• Principal Investigator: ENISHI Tetsuya 徳島大学, 病院, 特任助教 (20467806)
• Co-Investigator(Kenkyū-buntansha): YASUI Natsuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00157984) ; TAKATA Shinjiro 徳島大学, 病院, 准教授 (20284292) ; YUKATA Kimimori 徳島大学, 病院, 特任助教 (40564430) ; SUGANUMA Katsuyoshi 徳島大学, 病院, 医員 (20444721)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 骨・軟骨代謝学 / 軟骨細胞 / 極性 / 成長軟骨板

Research Abstract

The rabbit growth plate was first cut in half, parallel to the longitudinal axis of the bone. The excised resting zone cartilage was rotated 90 degrees to bring the resting zone alongside the original growth plate. Seven days after surgery, chondrocytes at the original growth plate near the ectopic resting zone had undergone an approximately 90-degree shift in orientation. In some of these growth plates, we obtained several candidate factors using DNA microarray. We investigated if these candidate factors are involved in the polarity of the growth plate. These results are valid to control the limb lengthening.

Research Products

• [Journal Article] Mineral to matrix ratio determines biomaterial and biomechanical properties of rat femur application of Fourier transform infrared spectroscopy (2011)
  • Author(s): Takata S, Yonezu H, Shibata A, Enishi T, Sato N, Takahashi M, Nakao S, Komatsu K, Yasui N
  • Journal Title: J Med Invest Volume: 28(3-4) Pages: 197-202
  • NAID: 130004822657
  • Peer Reviewed
• [Journal Article] Locally administered zoledronic Acid therapy for giant cell tumor of bone (2011)
  • Author(s): Nishisho T, Hanaoka N, Endo K, Takahashi M, Yasui N
  • Journal Title: Orthopedics Volume: 34(7)
  • Peer Reviewed
• [Journal Article] Extraskeletal Ewing' s sarcoma in a 67-year-old man (2011)
  • Author(s): Hanaoka N, Goto T, Kasai T, Matsuura T, Nishisho T, Enishi T, Yasui N
  • Journal Title: J Orthop Sci Volume: 16(2) Pages: 250-2
  • Peer Reviewed
• [Journal Article] Mineral to matrix ratio determines biomaterial and biomechanical properties of rat femur application of Fourier transform infrared spectroscopy (2011)
  • Author(s): Takata S
  • Journal Title: J Med Invest Volume: 58 Pages: 197-202
  • NAID: 130004822657
  • Peer Reviewed
• [Journal Article] Extraskeletal Ewing's sarcoma in a 67-year-old man (2011)
  • Author(s): Hanaoka N
  • Journal Title: J Orthop Sci Volume: 16 Pages: 250-252
  • Peer Reviewed
• [Journal Article] Differential expression of Tenomodulin and Chondromodulin-1 at the insertion site of the tendon reflects a phenotypic transition of the resident cells (2010)
  • Author(s): Yukata K, Matsui Y, Shukunami C, Takimoto A, Hirohashi N, Ohtani O, Kimura T, Hiraki Y, Yasui N
  • Journal Title: Tissue Cell Volume: 42(2) Pages: 116-20
  • Peer Reviewed
• [Journal Article] Diffuse arachnoid ossification and multiple arachnoid cysts presenting with progressive thoracic myelopathy (2010)
  • Author(s): Sakai T, Sairyo K, Kashima M, Kosaka H, Katoh S, Yasui N
  • Journal Title: Skeletal Radiol Volume: 39(3) Pages: 299-304
  • Peer Reviewed
• [Journal Article] Causes of radiculopathy in young athletes with spondylolysis (2010)
  • Author(s): Sairyo K, Sakai T, Amari R, Yasui N
  • Journal Title: Am J Sports Med Volume: 38(2) Pages: 357-62
  • Peer Reviewed
• [Journal Article] The value of using radiographic criteria for the treatment of persistent symptomatic olecranon physis in adolescent throwing athletes (2010)
  • Author(s): Matsuura T, Kashiwaguchi S, Iwase T, Enishi T, Yasui N
  • Journal Title: Am J Sports Med Volume: 38(1) Pages: 141-5
  • Peer Reviewed
• [Journal Article] Cervical and upper thoracic screwing for spinal fusion : strategy for its safe insertion to avoid major complications (2009)
  • Author(s): Sairyo K, Sakai T, Higashino K, Tamura T, Katoh S, Yasui N
  • Journal Title: Arch Orthop Trauma Surg Volume: 129(11) Pages: 1447-52
  • Peer Reviewed
• [Journal Article] Arthroplasty using a custom-made cemented total hip prosthesis for an extensive giant cell tumor of the proximal femur : report of a patient followed up for over 30 years (2009)
  • Author(s): Nakano S, Enishi T, Hasan MY, Hanaoka N, Kawasaki Y, Egawa H, Kinoshita I, Yasui N
  • Journal Title: Arch Orthop Trauma Surg Volume: 129(9) Pages: 1171-5
  • Peer Reviewed
• [Journal Article] The effect of rheumatoid arthritis on the anatomy of the female cervical spine : a radiological study (2009)
  • Author(s): Higashino K, Sairyo K, Katoh S, Nakano S, Enishi T, Yasui N
  • Journal Title: J Bone Joint Surg Br Volume: 91(8) Pages: 1058-63
  • Peer Reviewed
• [Journal Article] Anterior transvertebral herniotomy for cervical disc herniation : a long-term follow-up study (2009)
  • Author(s): Sakai T, Katoh S, Sairyo K, Tamura T, Hirohashi N, Higashino K, Yasui N
  • Journal Title: J Spinal Disord Tech Volume: 22(6) Pages: 408-12
  • Peer Reviewed
• [Journal Article] Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma : identification of a novel type of LPP-HMGA2 transcript in four cases (2009)
  • Author(s): Kubo T, Matsui Y, Naka N, Araki N, Goto T, Yukata K, Endo K, Yasui N, Myoui A, Kawabata H, Yoshikawa H, Ueda T
  • Journal Title: Anticancer Res Volume: 29(6) Pages: 2357-60
  • Peer Reviewed
• [Journal Article] Optimal increase in bone mass by continuous local infusion of alendronate during distraction osteogenesis in rabbits (2009)
  • Author(s): Abbaspour A, Takahashi M, Sairyo K, Takata S, Yukata K, Inui A, Yasui N
  • Journal Title: Bone Volume: 44(5) Pages: 917-23
  • Peer Reviewed
• [Journal Article] Minimally invasive technique for direct repair of pars interarticularis defects in adults using a percutaneous pedicle screw and hook-rod system (2009)
  • Author(s): Sairyo K, Sakai T, Yasui N
  • Journal Title: J Neurosurg Spine Volume: 10(5) Pages: 492-5
  • Peer Reviewed
• [Presentation] The fate of chondrocyte-like cells during distraction osteogenesis in the rabbits (2011)
  • Author(s): 江西哲也
  • Organizer: ASBMR 2011 annual meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-09-19
• [Presentation] The fate of chondrocyte-like cells during distraction osteogenesis in the rabbits (2011)
  • Author(s): 江西哲也
  • Organizer: ASBME 2011 annual meeting
  • Place of Presentation: San diego, USA
  • Year and Date: 2011-09-19
• [Presentation] Significant fracture-dislocation of the thoracic or lumbar spine without neurologic deficit : A report of two cases (2011)
  • Author(s): 江西哲也
  • Organizer: The 2011 International Conference on Spinal Cord Medicine and Rehabilitation
  • Place of Presentation: Washington, D. C., USA
• [Presentation] The fate of chondrocyte-like cells during distraction osteogenesis in the rabbits (2011)
  • Author(s): 江西哲也
  • Organizer: ORS 2011 annual meeting
  • Place of Presentation: Long beach, CA, USA
• [Presentation] Significant fracture-dislocation of the thoracic or lumbar spine without neurologic deficit : A report of two cases (2011)
  • Author(s): 江西哲也
  • Organizer: The 2011 International Conference on Spinal Cord Medicine and Rehabilitation
  • Place of Presentation: Washington, D.C., USA