Induction of the tumor immune response by the dendritic cell targeting of the autoantigen mimotope.
| Project/Area Number |
21659374
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
HANAFUSA Tadashi 岡山大学, 自然生命科学研究支援センター, 助教 (00228511)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,850,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2009: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 腫瘍学 / ミモトープ / 癌 / 免疫学 / PCDH11Y / 免疫療法 / PCDHllY / 前立腺癌 / 前立腺がん / がん抗原 / 樹状細胞 |
|---|
| Research Abstract |
In this study, I tried to identify the CD8 T-cell epitopes and its mimotopes of PCDH11Y that is expressed on prostate cancer cells, and tried to induce tumor specific immune response by dendritic cell targeting of its sequence. I didn' t succeed the isolation of epitopes, but I succeeded the construction of scFv antibody that recognizes the extracellular domain of PCHD11Y, and its humanization. I postulated that the induction of tumor specific immune response could be induced using this antibody by the ADCC mechanism.
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Report
(4 results)
Research Products
(9 results)
