• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

偏光感受型・前眼部三次元光干渉断層計の開発と臨床応用

Research Project

Project/Area Number 21659397
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionUniversity of Tsukuba

Principal Investigator

大鹿 哲郎  筑波大学, 筑大学院・人間総合科学研究科, 教授 (90194133)

Co-Investigator(Kenkyū-buntansha) 安野 嘉晃  筑波大学, 大学院・数理物質科学研究科, 助教 (10344871)
平岡 孝浩  筑波大学, 大学院・人間総合科学研究科, 講師 (30359575)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2009: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords偏光 / OCT / 光干渉断層計 / 前眼部
Research Abstract

世界初の偏光感受型・高侵達・前眼部三次元光干渉断層計(optical coherence tomography,OCT)を開発する目的で,光源1.3μm,200x200のAライン測定を2秒で行う波長走査型光干渉断層計を組み立て,臨床応用を行った.光源側にelectro-optic polarization modulatorを,検出側にpolarization-sensitive detectorを配置し,組織の偏光特性を測定する構成とした.通常のOCT画像と偏光感受型tomography,すなわちphase retardation tomographyを同時に測定するものである.このシステムを正常ヒト篤志者にて最適化し,偏光感受型・前眼部三次元光干渉断層計撮影を行い,従来の光干渉断層計では検出困難であった強膜岬,線維柱帯,強膜角膜移行部などの検出率を検討した.また,組織内構成要素の分離検出精度を検討し,波長走査型光干渉断層計の所見と比較することにより,各組織における光干渉断層所見の特徴を分類することを試みた.さらに,角膜疾患,角膜移植後眼,円錐角膜眼,壊死性強膜炎眼,緑内障眼,濾過胞手術後眼などの各疾患眼において,角膜および強膜における複屈折(birefringence)変化を検討した.装置の深さ方向の解像度は8.3μm,スキャン速度は30,000/sである.その結果,濾過胞の水隙の上方に強い複屈折を認め,組織の線維化が生じている部位があることが示された.角膜移植後眼では,複屈折が増強している部分が炎症あるいはコラーゲンの異常なクロスリンキングが生じている部位に相当していた.強膜炎眼では,強膜の菲薄化と組織の脆弱化部分が示された.我々は本研究において,網膜と同様に前眼部における複屈折変化を捉えることにより,組織の形態変化だけでなく,組織内の繊維走行の変化や創傷治癒過程の解析,構造内要素の分離検出などを行うことを試みた.

Report

(2 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (18 results)

  • [Journal Article] Wound architecture of clear corneal incision with or without stromal hydration observed with 3-dimensional optical coherence tomography2011

    • Author(s)
      Fukuda S, Kawana K, Yasuno Y, Oshika T
    • Journal Title

      Am J Ophthalmol

      Volume: 151 Pages: 413-419

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeatability and reproducibility of anterior chamber volume measurement using 3-dimensional anterior segment optical coherence tomography2011

    • Author(s)
      Fukuda S, Kawana K, Yasuno Y, Oshika T
    • Journal Title

      J Cataract Refract Surg

      Volume: 37 Pages: 461-468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography2010

    • Author(s)
      Yasuno Y, Yamanari M, Kawana K, Miura M, Fukuda S, Makita S, Sakai S, Oshika T
    • Journal Title

      J Biomed Opt

      Volume: 15 Pages: 61705-61705

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeatability and reproducibility of anterior ocular biometric measurements with 2-dimensional and 3-dimensional optical coherence tomography2010

    • Author(s)
      Fukuda S, Kawana K, Yasuno Y, Oshika T
    • Journal Title

      J Cataract Refract Surg

      Volume: 36 Pages: 1867-1873

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography2009

    • Author(s)
      Yasuno Y, Yamanari M, Kawana K, Oshika T, Miura M
    • Journal Title

      Optics Express 17

      Pages: 3980-3996

    • NAID

      120007137604

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of sub-retinal pigment epithelium morphologies of exudative macualr diseases by high-penetration optical coherence tomography2009

    • Author(s)
      Yasuno Y, Miura M, Kawana K, Makita S, Sato M, Okamoto F, Yamanari M, Iwasaki T, Yatagai T, Oshika T
    • Journal Title

      Invest Ophthalmol Vis Sci 50

      Pages: 405-413

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography2009

    • Author(s)
      Kawana K, Kiuchi T, Yasuno T, Oshika T
    • Journal Title

      Ophthalmology 116

      Pages: 848-855

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of multifocal choroiditis with panuveitis by three-dimensional high-penetration optical coherence tomography2009

    • Author(s)
      Yasuno Y, Okamoto F, Kawana K, Yatagai T, Oshika T
    • Journal Title

      J Biophotonics 2

      Pages: 435-441

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] n vivo investigation of cornea and anterior segment using office based polarization sensitive swept-source optical coherence tomography2011

    • Author(s)
      Lim Y, Yamanari M, Fukuda S, Kaji Y, Kiuchi T, Miura M, Oshika T, Yasuno Y
    • Organizer
      BiOS-SPIE Photonics West 2011
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2011-01-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optical rheology of porcine sclera by polarization-sensitive optical coherence tomography2011

    • Author(s)
      Yamanari M, Ishii K, Miura M, Oshika T, Yasuno Y
    • Organizer
      BiOS-SPIE Photonics West 2011
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2011-01-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前眼部三次元光干渉断層計による不全濾過胞の病態分類2010

    • Author(s)
      木内貴博, 川名啓介, 大鹿哲郎
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 3種類の前眼部形状解析装置の円錐角膜眼における比較2010

    • Author(s)
      上野勇太, 平岡孝浩, 渡部大樹, 大鹿哲郎
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 偏光OCTによる豚眼強膜の光レオロジー2010

    • Author(s)
      山成正宏, 石井晃太郎, 三浦雅博, 大鹿哲郎, 安野嘉晃
    • Organizer
      Optics & Photonics Japan 2010
    • Place of Presentation
      東京
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 偏光OCTによる前眼部解析2010

    • Author(s)
      リン・イー・ヘン, 山成正宏, 福田慎一, 加治優一, 木内貴博, 三浦雅博, 大鹿哲郎, 安野嘉晃
    • Organizer
      Optics & Photonics Japan 2010
    • Place of Presentation
      東京
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Office based polarization sensitive anterior eye segment optical coherence tomography2010

    • Author(s)
      Lim Y, Yamanari M, Miura M, Oshika T, Yasuno Y
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida (USA)
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tissue contrast imaging of anterior eye based on optical properties measured by polarization sensitive optical coherence tomography2010

    • Author(s)
      Miyazawa A, Yamanari M, Makita S, Miura M, Kawana K, Iwaya K, Goto H, Oshika T, Yasuno Y
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wavefront aberrations and modulation transfer functions of multifocal intraocular lenses in visible and infrared wavelengths2010

    • Author(s)
      Hirohara Y, Saika M, Fujikado T, Oshika T, Mihashi T
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Investigation of retinal micro-structure by adaptive optics scanning laser ophthalmoscope with 1-micrometer wavelength probe2009

    • Author(s)
      Yasuno Y, Kurokawa K, Makita S, Miura M, Kawana K, Okamoto F, Oshika T
    • Organizer
      European Conference on Biomedical Optics
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2009-06-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of limbus- and fornix-based trabeculectomy blebs using three dimensional cornea and anterior segment optical coherence tomography2009

    • Author(s)
      Kawana K, Kiuchi T, Yasuno T, Oshika T
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2009-05-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Standard- and high-resolution investigation of age-related macular degeneration by high-penetration optical coherence tomography with one micrometer probe2009

    • Author(s)
      Kawana K, Kiuchi T, Yasuno T, Oshika T
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2009-05-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Improved visualization of trabecular meshwork by polarization sensitive optical coherence tomography2009

    • Author(s)
      Yasuno Y, Kawana K, Yamanari M, Miura M, Fukuda S, Oshika T
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2009-05-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Three-dimensional analysis of laser peripheral iridotomy by suing three-dimensional cornea and anterior segment optical coherence tomography2009

    • Author(s)
      Miyai N, Kawana K, Kiuchi T, Yasuno Y, Oshiwa T
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2009-05-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of two- and tree-dimensional anterior segment optical coherence tomography in the evaluation of anterior chamber angle structures and parameters in two- and three-dimensional anterior segment optical coherence tomography2009

    • Author(s)
      Nakakuki N, Kawana K, Yasuno Y, Oshika T
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2009-05-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Discrimination of conjunctiva and sclera by analysis of local statistics of polarization sensitive optical coherence tomograpyh images2009

    • Author(s)
      Miyazawa A, Yamanari M, Makita S, Miura M, Kawana K, Oshika T
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2009-05-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vsualization of human photoreceptors using 1μm wavelength adaptive optics scanning laser ophthalmoscope2009

    • Author(s)
      Kurokawa K, Makita S, Miura M, Kawana K, Okamoto F, Oshika T, Yasuno Y
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida(USA)
    • Year and Date
      2009-05-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超高分解能レーザー走査検眼鏡による正常眼視細胞・血流の直接可視化2009

    • Author(s)
      安野嘉晃, 黒川和博, 玉田大輝, 巻田修一, 三浦雅博, 川名啓介, 岡本史樹, 大鹿哲郎
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi