| Project/Area Number |
21659414
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
OGURA Hiroshi 大阪大学, 医学系研究科, 准教授 (70301265)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hisashi 大阪大学, 名誉教授 (90127241)
KUWAGATA Yasuyuki 大阪大学, 医学系研究科, 招へい教授 (50273678)
MATSUMOTO Naoya 大阪大学, 医学部附属病院, 助教 (50359808)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 熱中症 / 再生 / 血管内皮 / 骨髄間質細胞 / 移植 / 治療 / 多臓器障害 / 臓器障害 / 細胞移植 / SIRS / DIC / MODS |
|---|
| Research Abstract |
The objectives of this study were to evaluate the pathophysiology and regenerative response of endothelium after heat stroke and to examine the effects of mesenchymal stem cells in a rat model. The serum concentrations of tumor necrosis factor alpha (TNF-α), interleukin-6, soluble thrombomodulin, and soluble endothelial selectin significantly increased at 3 and 6 hours after heat stroke. In the lung, interstitial edema, structural disruption of the alveolar lumen, and intra-alveolar hemorrhage were observed at 6 hours after heat stroke. Transplantation of mesenchymal stem cells was conducted to evaluate the effects to inhibit the production of inflammatory cytokines, protect against endothelial damage and improve survival in a rat model with heat stress.
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