Analysis of the origin and properties of dental and bone marrow mesenchymal stem cells by using mice to label NC-derived and mesodermal cells
| Project/Area Number |
21659422
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMANE Toshiyuki 三重大学, 大学院・医学系研究科, 講師 (30452220)
KAWAZOE Shinjiro 三重大学, 大学院・医学系研究科, 助教 (30467360)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 神経堤細胞 / 中胚葉 / 間葉系細胞 / 歯髄細胞 / 骨髄間葉系細胞 / 象牙芽細胞 / 胚性幹細胞 / 細胞系譜追跡 / 間葉細胞 / 歯髄 / 骨髄 / 間葉系幹細胞 / 造血支持能 / CFU-F / 骨髄細胞 / 幹細胞 / 歯 / 分化能 |
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| Research Abstract |
By using transgenic mouse which enabled us to trace NC-derived or mesodermal cells, we showed that dental mesenchyme was composed of mainly NC-derived cells, whereas half of bone marrow(BM) mesenchyme was composed of cells other than NC-derived and mesodermal cells. Furthremore, a colony-forming unit-fibroblast(CFU-F) assay indicated that CFU-Fs in the dental pulp are derived from NC, and BM are derived from both NC and mesodermal cells. Furthermore, we showed that dental mesenchyme supported the differentiation of B lymphocytes and osteoclasts.
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Report
(4 results)
Research Products
(35 results)
