| Project/Area Number |
21659427
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
NAKASHIMA Tomoki 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00346959)
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|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,350,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2009: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | 口腔生化学 / 骨代謝学 / 骨構成細胞 / カップリング / 骨リモデリング / 破骨細胞 / 骨芽細胞 |
|---|
| Research Abstract |
Bone remodeling optimizes bone strength. Regulation of bone remodeling requires a tightly orchestrated interplay among osteoblasts(bone forming cells), osteoclasts(bone resorbing cells) in bone surface and osteocytes, which embedded into bone matrix. To identify the regulation/coupling factor of bone remodeling, we investigated a genome-wide screening, proteome analysis of these bone cells and in vivo analysis of gene targeting mice.
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