Study of Dentin regeneration based on extracellular calcium and phosphate.
| Project/Area Number |
21659437
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
NEMOTO Eiji 東北大学, 大学院・歯学研究科, 准教授 (40292221)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIMAUCHI Hidetoshi 東北大学, 大学院・歯学研究科, 教授 (70187425)
KANAYA Sousuke 東北大学, 病院, 医員 (80375097)
TADA Hiroyuki 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70431632)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | 象牙質 / 細胞外カルシウム / 細胞外リン酸 / ヒト歯髄細胞 / ヒト歯根膜細胞 |
|---|
| Research Abstract |
It is one of the big aims of dentistry to reproduce a tooth substance (dentin)which is lost in caries. Growth factor BMP-2 regulates odontoblastic differentiation to make dentin. I clarified that the expression of BMP-2 gene was enhanced in human pulp cells upon stimulation with not only 10 mM calcium ion but also 3 mM inorganic phosphate via ERK/MAPK signaling pathway. This finding suggested possibility to be connected for a cure to enhance expression of BMP-2 in dentistry in future.
|
Report
(4 results)
Research Products
(38 results)
