| Project/Area Number |
21659442
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SASAKI Keiichi 東北大学, 大学院・歯学研究科, 教授 (30178644)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Yasuo 東北大学, 大学院・歯学研究科, 大学院非常 (50005039)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | レジン / アレルギー / 生体材料 / 免疫 / 炎症 / 歯学 / 免疫学 / 薬理学 / レジンモノマー / レジンアレルギー / アレルゲン |
|---|
| Research Abstract |
At the start of the project, we were thinking that we had succeed in establishing the murine model of resin allergy by experiments using a preparation of resin monomer methyl methacrylate(MMA)that is clinically used in dentistry. However, in later experiments using a reagent grade of MMA, we could not reproduce it, leading us to speculate that"LM might promote allergies to allergens other than LM". Metal allergies are dentistry-associated allergies with a high incidence. Thus, we examined the adjuvant effect of RM on Ni-allergy. We found that both MMA and 2-hydroxyethyl methacrylate(HEMA)are inflammatory and promote Ni allergy in mice. Various microbial substances and nitrogen-containing bisphosphonates(NBPs, anti-bone-resorptive drugs)also promoted Ni allergy. These findings suggest that inflammatory chemicals, as well as oral bacteria, may promote metal allergies as an immunological adjuvant.
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