• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of microRNAs and their target genes associated with phenotypes of oral squamous cell carcinomas.

Research Project

Project/Area Number 21659469
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKochi University

Principal Investigator

YAMAMOTO Tetsuya  高知大学, 教育研究部・医療学系, 教授 (00200824)

Co-Investigator(Kenkyū-buntansha) SASABE Eri  高知大学, 教育研究部・医療学系, 助教 (40363288)
MORISHITA Keiko  高知大学, 教育研究部・医療学系, 助教 (10527584)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2009: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords口腔扁平上皮癌 / マイクロRNA / 悪性形質 / エクソソーム
Research Abstract

We investigated the expression of microRNAs in oral squamous cell carcinoma(OSCC) cell lines and normal oral keratinocytes by using microarray analysis and real time-PCR. It was demonstrated that the expression of 9 microRNAs was up-regulated and that of 13 microRNAs was down-regulated in OSCC cells compared with normal cells. We also revealed that miR-34a, one of down-regulated genes, acts as a tumor suppressor gene in OSCC cells and that the expression of the microRNA is down-regulated in OSCC tissues.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Book (1 results) Remarks (2 results)

  • [Journal Article] The involvement of hypoxia-inducible factor-1α in the susceptibility to γ-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells2010

    • Author(s)
      Eri sasabe, Xuan Zhou, Dechao Li, Naohisa Oku, Tetsuya yamamoto, Tokio osaki
    • Journal Title

      Recent Advances and Research Updates 11

      Pages: 121-136

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ビスフォスフォネート投与と関連性があると考えられた顎骨骨髄炎ならびに顎骨壊死30症例に関する追跡調査~2年後の現状について~2009

    • Author(s)
      浦出雅裕, 田中徳昭, 嶋田淳, 柴田孝典, 古澤清文, 桐田忠昭, 山本哲也, 渡辺哲郎, 北川善政, 倉科憲治, 瀬戸宗一, 福田仁一
    • Journal Title

      日本口腔外科学会雑誌 55巻

      Pages: 553-561

    • NAID

      10027091304

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The down-regulated micro RNA in oral squamous cell carcinoma acts as a tumor suppressor2011

    • Author(s)
      Tomohide Yoshimura, Ge Huabing, Wang Jianguo, Eri Sasabe, Tomohiro Yamada, Tetsuya Yamamoto
    • Organizer
      American Association of Oral and Maxillofacial Surgeons. 2011 Annual Meeting
    • Place of Presentation
      Philadelphia Convention Center, Philadelphia, USA
    • Year and Date
      2011-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] The down-regulated micro RNA in oral squamous cell carcinoma acts as a tumor suppressor2011

    • Author(s)
      Tomohide Yoshimura, Ge Huabing, Wang Jianguo, Eri Sasabe, Tomohiro Yamada, Tetsuya Yamamoto
    • Organizer
      American Association of Oral and Maxillofacial Surgeons 2011 Annual Meeting
    • Place of Presentation
      Philadelphia Convention Center, Philadelphia, USA
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞の放射線感受性に及ぼすマイクロRNAの影響に関する検討2011

    • Author(s)
      吉村友秀、笹部衣里、葛化冰、北村直也、山本哲也
    • Organizer
      第65回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌細胞の放射線感受性に及ぼすマイクロRNAの影響に関する検討2011

    • Author(s)
      吉村友秀、笹部衣里、葛化冰、北村直也、山本哲也
    • Organizer
      第65回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるマイクロRNAの発現と増殖・浸潤における役割についての検討2010

    • Author(s)
      吉村友秀、笹部衣里、北村直也、山本哲也
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知
    • Year and Date
      2010-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるマイクロRNAの発現と増殖・浸潤における役割についての検討2010

    • Author(s)
      吉村友秀、笹部衣里、北村直也、山本哲也
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知城ホール(高知)
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞におけるマイクロRNAの発現変化ならびにその機能2010

    • Author(s)
      吉村友秀、笹部衣里、森下慶子、山田朋弘、山本哲也
    • Organizer
      第64回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるマイクロRNAの発現と増殖・浸潤における役割についての検討2010

    • Author(s)
      吉村友秀、笹部衣里、森下慶子、山田朋弘、山本哲也
    • Organizer
      第64回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      札幌プリンスホテル国際館パミール(札幌)
    • Related Report
      2010 Annual Research Report
  • [Book] 口腔外科学(第3版)2010

    • Author(s)
      山本哲也
    • Total Pages
      21
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kochi-ms.ac.jp/~fm_dntst/index.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kochi-ms.ac.jp/~fm_dntst/index.htm

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi