Effect a removal of oral biofilm on pathogenesis factor of child diabetes

• Project/Area Number: 21659475
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: KOZAI Katsuyuki 広島大学, 大学院・医歯薬学総合研究科, 教授 (10178212)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Junji 広島大学, 大学院・医歯薬学総合研究科, 准教授 (90263714) ; MITSUHATA Chieko 広島大学, 大学院・医歯薬学総合研究科, 助教 (10335664)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 小児糖尿病 / 口腔バイオフィルム / 歯周病原細菌 / 1型糖尿病 / HbA1c / 小児歯周病 / 糖尿病マウス / HbAlc / 硝酸メチル

Research Abstract

Type I diabetes mellitus occurs in an early stage of the childhood. The ratios of BOP+ children decreased from 96. 4% to 60%(p<0. 05). Also, in the DM group, the number of BOP showed a low value per person as compared with 2005DM group in 2011. Furthermore, we showed the tendency that the number of BOP increased with the increase of the HbA1c level. The intraoral bacteria rate of detection of A. a, P. g, P. i, T. d, T. f which were periodontal pathogenic bacteria were found little difference.
However, as for the rate of detection of T. f of the periodontal disease risk factor, T. f(approximately 95% of rate of detection) was higher in children with type I diabetes mellitus than healthy child(80% of rate of detection). Oral care for childhood type I diabetes mellitus improved an intraoral inflammatory state and suggested that it is important to the oral care to affection children

Research Products

• [Journal Article] 1型糖尿病キャンプ参加患児の口腔内状況の評価 (2012)
  • Author(s): 有木美早、光畑智恵子、中岡美由紀、香西克之
  • Journal Title: 小児歯誌 Volume: 50 Pages: 197-197
  • NAID: 10030558713
• [Journal Article] 小児領域における歯周疾患を考える(1)歯周疾患の分類 (2010)
  • Author(s): 鈴木淳司, 香西克之
  • Journal Title: 小児歯科臨床 Volume: 15(2) Pages: 49-53
• [Journal Article] 小児領域における歯周疾患を考える(2)歯肉炎と歯周炎の相違 (2010)
  • Author(s): 鈴木淳司, 香西克之
  • Journal Title: 小児歯科臨床 Volume: 15(3) Pages: 37-39
• [Journal Article] 小児歯科領域における歯周疾患を考える(1)歯周疾患の分類 (2010)
  • Author(s): 鈴木淳司, 香西克之
  • Journal Title: 小児歯科臨床 15・2 Pages: 49-53
• [Journal Article] 小児歯科領域における歯周疾患を考える(2)歯肉炎と歯周炎の相違 (2010)
  • Author(s): 鈴木淳司, 香西克之
  • Journal Title: 小児歯科臨床 15・3 Pages: 37-39
• [Journal Article] (2009)
  • Author(s): 林文子, 鈴木淳司, 香西克之ほか
  • Journal Title: 広島大学学部・附属学校共同研究機構研究紀要 Volume: 37 Pages: 275-278
• [Presentation] 1型糖尿病キャンプ参加患児の口腔内状況の評価 (2012)
  • Author(s): 有木美早、光畑智恵子、中岡美由紀、香西克之
  • Organizer: 第50回日本小児歯科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2012-05-12
• [Presentation] 小児歯科からみた最近のトピックス (2011)
  • Author(s): 香西克之
  • Organizer: 第33回広島県小児保健研究会
  • Place of Presentation: 広島市民病院講堂(招待講演)
  • Year and Date: 2011-06-26
• [Presentation] Etiology and clinicalapproach for periodontal disease ofchildren (2010)
  • Author(s): Katsuyuki Kozai
  • Organizer: 九州大学JICA研修講演
  • Place of Presentation: 九州大学
  • Year and Date: 2010-06-01
• [Presentation] 小児の歯周疾患の発症に関する基礎的研究 (2009)
  • Author(s): 鈴木淳司
  • Organizer: 第47回日本小児歯科学会
  • Place of Presentation: 大阪大学
  • Year and Date: 2009-05-15
• [Presentation] 小児歯周疾患の発症に関する基礎的研究 (2009)
  • Author(s): 鈴木淳司
  • Organizer: 日本小児歯科学会
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2009-05-15
• [Book] 小児の歯周疾患,小児の歯周疾患治療, Pediatric Dentistry(第3版小児歯科学モンゴル語訳) (2009)
  • Author(s): 香西克之(分担執筆)
  • Publisher: 医歯薬出版