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Peroxisome proliferator-activated receptor gamma polymorphism andperiodontitis, preterm birth and obesity in pregnant Japanese women

Research Project

Project/Area Number 21659480
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

YOSHIE Hiromasa  新潟大学, 医歯学系, 教授 (20143787)

Co-Investigator(Kenkyū-buntansha) SUGITA Noriko  新潟大学, 医歯学系, 助教 (30313547)
Co-Investigator(Renkei-kenkyūsha) KIKUCHI Akira  新潟大学, 医歯学総合病院, 講師 (30293228)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords歯周病 / 産科学 / ゲノム / 遺伝子型 / 肥満 / PPAR / 早産 / 核内レセプター
Research Abstract

PPAR gamma is a nuclear hormone receptor which regulates lipid metabolism and production of inflammatory cytokines. A functional genetic polymorphism Pro12Ala has been reported. Recent studies have suggested an association between periodontitis and preterm birth or obesity. We investigated relationships between PPAR gamma polymorphism, periodontitis, preterm birth and obesity in pregnant Japanese women. There was no significant association between periodontitis and preterm birth, or between periodontitis and obesity. However, a significant association of the polymorphism and periodontitis was found in the Japanese pregnant women.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (18 results) Remarks (2 results)

  • [Journal Article] FcγRIIB-nt645+25A? G gene polymorphism and periodontitis in Japanese women with preeclampsia2012

    • Author(s)
      Wang Y, Sugita N(2番目), Kikuchi A(3番目), Yoshie H(9番目), 他5名
    • Journal Title

      International Journal of Immunogenetics

      Volume: (in press) Issue: 6 Pages: 492-500

    • DOI

      10.1111/j.1744-313x.2012.01124.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association of Aggregatibacter actinomycetemcomitans with preeclampsia in a subset of Japanese pregnant women2012

    • Author(s)
      Hirano E, Sugita N(2番目), Kikuchi A(3番目), Yoshie H(8番目), 他4名
    • Journal Title

      Journal of Clinical Periodontology

      Volume: 39 Pages: 229-38

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunoregulatory gene polymorphisms in Japanese women with preterm births and periodontitis2012

    • Author(s)
      Sugita N, Kikuchi A(3番目), Yoshie H(8番目), 他5名
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 93 Pages: 94-101

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association of Aggregatibacter actinomycetemcomitans with preeclampsia in a subset of Japanese pregnant women2012

    • Author(s)
      Emi Hirano
    • Journal Title

      Journal of Clinical Periodontology

      Volume: 39 Pages: 229-238

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FcγRIIB polymorphisms, periodontitis and preterm birth in Japanese pregnant women2011

    • Author(s)
      Iwanaga R, Sugita N(2番目), Kikuchi A(5番目), Yoshie H(7番目), 他3名
    • Journal Title

      Journal of Periodontal Research

      Volume: 46 Issue: 3 Pages: 292-302

    • DOI

      10.1111/j.1600-0765.2010.01338.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] FcyRIIB polymorphisms, periodontitis and preterm birth in Japanese pregnant women.2011

    • Author(s)
      Ruriko Iwanaga
    • Journal Title

      Journal of Periodontal Research

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor gamma polymorphism and periodontitis in pregnant Japanese women2010

    • Author(s)
      Hirano E, Sugita N(2番目), Kikuchi A(3番目), Yoshie H(8番目), 他4名
    • Journal Title

      Journal of Periodontology

      Volume: 81 Pages: 897-906

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein2010

    • Author(s)
      Shimada Y, Sugita N(5番目), Yoshie H(6番目), 他3名
    • Journal Title

      Journal of Periodontology

      Volume: 81 Pages: 1118-1123

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma polymorphism and periodontitis in pregnant Japanese women.2010

    • Author(s)
      Emi Hirano
    • Journal Title

      Journal of Periodontology

      Volume: Vol.81 Pages: 897-906

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma polymorphism and periodontitis in pregnant women.2010

    • Author(s)
      Emi HIrano
    • Journal Title

      Journal of Periodontology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibody responses to Porphyromonas gingivalis outer membrane protein in the first trimester2009

    • Author(s)
      Sasahara J, Kikuchi A(2番目), Sugita N(4番目), Yoshie H(6番目), 他3名
    • Journal Title

      Australian and New Zealand Journal of Obstetrics and Gynecology

      Volume: 49 Pages: 137-141

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Association of FcγRIIB-nt645+25A/G gene polymorphism with preeclampsia and periodontitis in pregnant Japanese women2011

    • Author(s)
      Wang Y, Sugita N(2番目), Kikuchi A(6番目), Yoshie H(8番目), 他3名
    • Organizer
      The 9th Asian Pacific Society of Periodontology Meeting
    • Place of Presentation
      Hong Kong
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of FcγRIIB-nt645+25A/G gene polymorphism with preeclampsia and periodontitis in pregnant Japanese women2011

    • Author(s)
      Wang Yang-Ming
    • Organizer
      The 9th meeting of the Asian Pacific Society of Periodontology
    • Place of Presentation
      香港,L'Hotel Nina et Convention Centre
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Infection with Aggregatibacter actinomycetemcomitans and preeclampsia2010

    • Author(s)
      Hirano E, Sugita N(2番目), Kikuchi A(3番目), Yoshie H(8番目), 他4名
    • Organizer
      The 58th Annual Meeting of the JADR
    • Place of Presentation
      Kitakyushu, Japan
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Infection with Aggregatibacter actinomycetemcomitans and preeclampsia.2010

    • Author(s)
      Emi Hirano
    • Organizer
      58^<th> Annual Meeting of the JADR
    • Place of Presentation
      北九州市
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] PPARγPro12Ala polymorphism and periodontitis in pregnant Japanese women2010

    • Author(s)
      Sugita N, Kikuchi A(3番目), Yoshie H(8番目), 他5名
    • Organizer
      The 96th Annual Meeting of the American Academy of Periodontology
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Infection with Aggregatibacter actinomycetemcomitans and adverse pregnancy outcomes2010

    • Author(s)
      Hirano E, Sugita N(2番目), Kikuchi A(3番目), Yoshie H(8番目), 他4名
    • Organizer
      The 96th Annual Meeting of the American Academy of Periodontology
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-10-31
    • Related Report
      2011 Final Research Report
  • [Presentation] The PPARyProl 2Ala polymorphism and periodontitis in pregnant Japanese women.2010

    • Author(s)
      Noriko Sugita
    • Organizer
      96^<th> Amual Meeting of the AAP-JSP
    • Place of Presentation
      米国、ホノルル
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Infection with Aggregatibacter actinomycetemcomitans and adverse pregnancy outcoms.2010

    • Author(s)
      Emi Hirano
    • Organizer
      96^<th> Annual Meeting of the AAP-JSP
    • Place of Presentation
      米国、ホノルル
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本人妊婦集団におけるFcγRIIB遺伝子多型と歯周炎および早産との関連性2010

    • Author(s)
      岩永璃子,杉田典子(2番目),吉江弘正(4番目)
    • Organizer
      日本歯周病学会秋季学術大会
    • Place of Presentation
      高松市
    • Year and Date
      2010-09-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 日本人妊婦集団におけるFcyRIIB遺伝子多型と歯周炎および早産との関連性2010

    • Author(s)
      岩永璃子
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      高松市
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] FcγRIIB polymorphisms associated with periodontits and preterm birth2010

    • Author(s)
      Iwanaga R, Sugita N(2番目), Kikuchi A(5番目), Yoshie H(7番目), 他3名
    • Organizer
      The 88th International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] FcyRIIB gene polymorphisms associated with periodontitis and specific antibody production.2010

    • Author(s)
      Noriko Sugita
    • Organizer
      88^<th> General session of the IADR
    • Place of Presentation
      スペイン王国、バルセロナ
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] FcγRIIB polymorphisms associated with periodontitis and preterm birth.2010

    • Author(s)
      Ruriko Iwanaga
    • Organizer
      88^<th> General session of the IADR
    • Place of Presentation
      スペイン王国、バルセロナ
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊婦における歯周病原細菌に対する血清抗体価の検索2009

    • Author(s)
      平野絵美,杉田典子(2番目),菊池朗(5番目),吉江弘正(8番目)他4名
    • Organizer
      日本口腔検査学会学術大会
    • Place of Presentation
      広島市
    • Year and Date
      2009-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯周病原細菌に対する免疫調節に影響する遺伝子多型と妊娠予後の関連性2009

    • Author(s)
      岩永璃子,杉田典子(3番目),菊池朗(5番目),吉江弘正(8番目), 他4名
    • Organizer
      日本歯周病学会秋季学術大会
    • Place of Presentation
      宮崎市
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] The PPARγ2 Pro12Ala polymorphism associated wth the risk of periodontitis in pregnant Japanese women2009

    • Author(s)
      Hirano E, Sugita N(2番目), Yoshie H(6番目), 他4名
    • Organizer
      EUROPERIO6
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] The PPARγ2 Pro12Ala polymorphism associated with the risk of periodontitis in pregnant Japanese women.2009

    • Author(s)
      Emi Hirano
    • Organizer
      EUROPERIO 6
    • Place of Presentation
      スウェーデン王国・ストックホルム
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 早産リスク因子としての歯周炎と免疫関連遺伝子多型の影響2009

    • Author(s)
      杉田典子,吉江弘正(5番目), 他3名
    • Organizer
      日本歯周病学会春季学術大会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-05-15
    • Related Report
      2011 Final Research Report
  • [Remarks] 杉田典子.総説:妊娠と歯周病.骨粗鬆症治療第9巻2号、45頁.先端医学社.東京, 2010.

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.niigata-u.ac.jp/dent/course/achievement.html

    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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