| Project/Area Number |
21659480
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGITA Noriko 新潟大学, 医歯学系, 助教 (30313547)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKUCHI Akira 新潟大学, 医歯学総合病院, 講師 (30293228)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 歯周病 / 産科学 / ゲノム / 遺伝子型 / 肥満 / PPAR / 早産 / 核内レセプター |
|---|
| Research Abstract |
PPAR gamma is a nuclear hormone receptor which regulates lipid metabolism and production of inflammatory cytokines. A functional genetic polymorphism Pro12Ala has been reported. Recent studies have suggested an association between periodontitis and preterm birth or obesity. We investigated relationships between PPAR gamma polymorphism, periodontitis, preterm birth and obesity in pregnant Japanese women. There was no significant association between periodontitis and preterm birth, or between periodontitis and obesity. However, a significant association of the polymorphism and periodontitis was found in the Japanese pregnant women.
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