The elucidation of the periodontosis using a three-dimensional cultivation system, and a metabolic syndrome related mechanism
| Project/Area Number |
21659487
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAITO Toshiyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (10170515)
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| Co-Investigator(Kenkyū-buntansha) |
FURUGEN Reiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (90253674)
福本 恵美子 東北大学, 歯科医療センター, 助教 (10264251)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,360,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | サイトカイン / レジスチン / 歯周病 / 3次元培養 / メタボリックシンドローム / シグナル伝達 / 単球 / 好中球 / アディポカイン / アディポネクチン / 脂肪細胞 |
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| Research Abstract |
Periodontal disease is local inflammation caused by periodontal pathogens and an association with immuno-response including various cytokines and activation of osteoclast has been clarified. On the other hand, it is reported that periodontal disease is associated with diabetes, arteriosclerosis, and cardiovascular disease, beyond periodontal inflammation and destruction, however, its mechanism has not been clarified well. In this study we hypothesized that periodontal disease has bad effects on glucose and lipid metabolism in the liver(Periodontol 2000 2007 : 43 : 254-66 Review). From a point of view that periodontal disease and various metabolic disorders affect each other, in order to clarify this, we examined it using 3 dimensional culture system in vitro. As a result, stimulation by LPS derived from periodontal pathogens has bad effects on release of resistin and adiponectin from adipocyte and macrophages. These phenomena were suggested to be one of mechanisms that periodontal disease influence systemic disease.
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Report
(4 results)
Research Products
(5 results)
