| Project/Area Number |
21659490
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Yoshiaki 鶴見大学, 歯学部, 准教授 (90350587)
IMAI Susumu 鶴見大学, 歯学部, 講師 (80072958)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | iPS細胞 / レトロウイルス / リポソーム / 歯科医療安全 / 歯科 / 医療安全 / 再生医療 / 歯根膜 / レトロウイルスベクター / リポソーム法 / Oct3/4 / Sox2 / Nanog / Klf4 / Lin28 / 歯科医療 |
|---|
| Research Abstract |
Traditional iPS cells establish methods used retrovirus transduction of the reprogramming 4 factors(Oct3/4, Sox2, Klf4, c-Myc) which results in viral integration into the genome. The use of retroviruses is potentially problematic for clinical applications involving cells derived from iPS cells due to the significant increased risk of inducing a cancer transformation. A non-viral gene delivery system should be required to establish iPS cells, for example lipsome methos.
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