Development of skin care in metabolic syndrome patients
| Project/Area Number |
21659494
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Fundamental nursing
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| Research Institution | Tokai University (2011)
The University of Tokyo (2009-2010) |
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Principal Investigator |
AKASE Tomoko 東海大学, 健康科学部, 准教授 (50276630)
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| Co-Investigator(Kenkyū-buntansha) |
SANADA Hiromi 東京大学, 医学系・研究科, 教授 (50143920)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGASE Takashi 東京大学, 医学系・研究科, 特任講師 (00359613)
MINEMASTU Takeo 東京大学, 医学系・研究科, 特任講師 (00398752)
SUGAMA Junko 金沢大学, 保健学系, 教授 (00203307)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,150,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2009: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 看護学 |
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| Research Abstract |
The purpose of this study was to grasp the actual condition of impaired skin in metabolic syndrome(MS), to elucidate the mechanism, to develop Scientifically-based skin care. We analyzed the skin tissue of MS model mouse. As a result, the thinning of the dermis and thickening of the subcutaneous fat and change of the collagen were observed. MS skin was potentially inflammatory condition. In addition, the high sensitivity to UV was revealed.
Its mechanisms are involved in oxidative stress. Usefulness of antioxidant therapy in applied to the skin and oral administration has been found.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Oxidative stress mediates skin fragility in obese diabetic mice2012
Author(s)
A Ibuki, T Akase, T Nagase, T Minematsu, G Nakagami, M Horii, H Sagara, T Komeda, M Kobayashi, T Shimada, M Aburada, K Yoshimura, J Sugama, H Sanada
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Journal Title
Experimental Dermatology
Volume: 21(3)
Pages: 178-183
Related Report
Peer Reviewed
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[Journal Article] Aging-Like Skin Changes Induced by Ultraviolet Irradiation in an Animal Model of Metabolic Syndrome2011
Author(s)
Akase T, Nagase T, Huang L, Ibuki A, Minematsu T, Nakagami G, Ohta Y, Shimada T, Aburada M, Sugama J, Sanada H.
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Journal Title
Biological Research for Nursing
Volume: 14(2)
Pages: 180-187
Related Report
Peer Reviewed
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[Journal Article] Aging-Like Skin Changes Induced by Ultraviolet Irradiation in an Animal Model of Metabolic Syndrome.2011
Author(s)
Akase T, Nagase T, Huang L, Ibuki A, Minematsu T, Nakagami G, Ohta Y, Shimada T, Aburada M, Sugama J, Sanada H.
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Journal Title
Biological Research for Nursing
Related Report
Peer Reviewed
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[Journal Article] Preventive effects of salacia reticulata on obesity and metabolic disorders in TSOD mice2009
Author(s)
Akase T, Shimada T, Harasawa Y, Akase T, Ikeya Y, Nagai E, Iizuka S, Nakagami G, Iizaka S, Sanada H, Aburada M.
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Journal Title
Evidence-based Complementary and Alternative Medicine
Volume: 2011
Issue: 1
Pages: 1-9
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Preventive effects of salacia reticulata on obesity and metabolic disorders in TSOD mice.2009
Author(s)
Akase T, Shimada T, Harasawa Y, Akase T, Ikeya Y, Nagai E, Iizuka S, Nakagami G, Iizaka S, Sanada H, Aburada M.
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Journal Title
Evidence-based Complementary and Alternative Medicine. doi:10.1093/ecam/nep052
Pages: 1-9
NAID
Related Report
Peer Reviewed
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[Presentation] スキン・ブロッティング～皮膚内部の非侵襲的アセスメントツール,メタボリックシンドロームにおける皮膚の形態学的特徴と皮下脂肪細胞のMMPsおよびTIMPsの発現異常2009
Author(s)
峰松健夫, 山本裕子, 黄麗娟, 仲上豪二朗, 赤瀬智子, 長瀬敬, 大江真琴, 森武俊, 須釜淳子, 真田弘美, 伊吹愛
Organizer
第20回日本創傷・オストミー・失禁管理学会学術集会,第39回日本創傷治癒学会
Place of Presentation
都市センターホテル(東京)
Year and Date
2009-12-08
Related Report
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