| Project/Area Number |
21659494
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Fundamental nursing
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| Research Institution | Tokai University (2011)
The University of Tokyo (2009-2010) |
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Principal Investigator |
AKASE Tomoko 東海大学, 健康科学部, 准教授 (50276630)
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| Co-Investigator(Kenkyū-buntansha) |
SANADA Hiromi 東京大学, 医学系・研究科, 教授 (50143920)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGASE Takashi 東京大学, 医学系・研究科, 特任講師 (00359613)
MINEMASTU Takeo 東京大学, 医学系・研究科, 特任講師 (00398752)
SUGAMA Junko 金沢大学, 保健学系, 教授 (00203307)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,150,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2009: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 看護学 |
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| Research Abstract |
The purpose of this study was to grasp the actual condition of impaired skin in metabolic syndrome(MS), to elucidate the mechanism, to develop Scientifically-based skin care. We analyzed the skin tissue of MS model mouse. As a result, the thinning of the dermis and thickening of the subcutaneous fat and change of the collagen were observed. MS skin was potentially inflammatory condition. In addition, the high sensitivity to UV was revealed.
Its mechanisms are involved in oxidative stress. Usefulness of antioxidant therapy in applied to the skin and oral administration has been found.
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