| Budget Amount *help |
¥94,770,000 (Direct Cost: ¥72,900,000、Indirect Cost: ¥21,870,000)
Fiscal Year 2013: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2012: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2011: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2010: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2009: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
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| Outline of Final Research Achievements |
We identified the progenitor homeodomain factor Dbx1 as a crucial genetic determinant of commissural neurons in the dorsal midbrain. We also found that the Dbx1-triggered transcriptional program ultimately induces the expression of Robo3 for midline crossing, which is hierarchically regulated via the expression of the homeodomain factor Evx2 at the postmitotic stage. Furthermore, we showed that Dbx1 suppresses in parallel the expression of ipsilateral neuron genetic programs to consolidate the identity of commissural neurons.
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