| Budget Amount *help |
¥104,260,000 (Direct Cost: ¥80,200,000、Indirect Cost: ¥24,060,000)
Fiscal Year 2013: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
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| Research Abstract |
The ascidian, Ciona intestinalis, belongs to the same phylum, Chordata, as vertebrates. We demonstrated that maternal information in eggs of the ascidian establishes five distinct initial states for gene networks. We analyzed the embryonic gene networks, which start from these five initial states. We found that a genetic circuit that could have been involved in emergence of vertebrate anterior placodes. We also identified Pinhead as a novel antagonist specific for Admp signaling molecule, which is used for establishment of the dorsoventral axis in animal embryos. Admp gene abuts on Pinhead gene in genomes from insects to vertebrates. We uncovered that this conserved genomic configuration is due to a novel DNA-loop mediated mechanism for transcriptional repression.
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