| Budget Amount *help |
¥100,230,000 (Direct Cost: ¥77,100,000、Indirect Cost: ¥23,130,000)
Fiscal Year 2013: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2012: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2011: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2010: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2009: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
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| Research Abstract |
Nonaqueous biocatalysis and vectorial sugar-chain immobilization techniques that we successfully developed in this project allowed to functionally design various glyco-biointerfaces with controlled nanostructures of bioactive oligosaccharides via cellulosic nano-assemblers obtained from wood. Cellular morphology, physiological activation and immunological responses through glyco-receptor mediated signaling strongly depended on the combination and nanostructures of plural oligosaccharides, eventually revealing the possibility of the direct stimulation to cultured cells in contact with the biointerfaces. A pioneering research "Glyco-nanoarchitectonics" will open up a new phase for research and developments of new-concept glyco-biomaterials in medical and cell engineering fields.
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