Analysis of neural circuit and synapse involved in learning and memory

• Project/Area Number: 21680027
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Kyoto University (2010-2011); Fujita Health University (2009)
• Principal Investigator: MATSUO Naoki 京都大学, 次世代研究者育成センター, 准教授 (10508956)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000); Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2009: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
• Keywords: シナプス / 遺伝子改変マウス / 記憶 / マウス

Research Abstract

I have analyzed the molecular and cellular changes induced by learning. For this aim, I have mainly focused on behaviorally activated neurons and synapses induced with learning by using transgenic mice which express GFP-GluR1 in response to behavioral stimuli in the brain.

Research Products

• [Journal Article] Locally synchronized synaptic inputs (2012)
  • Author(s): Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N, Ikegaya Y
  • Journal Title: Science Volume: 335 Issue: 6066 Pages: 353-356
  • DOI: 10.1126/science.1210362
  • Peer Reviewed
• [Journal Article] 記憶の獲得と想起:記憶痕跡の解明に向けたアプローチ (2011)
  • Author(s): 松尾直毅
  • Journal Title: 細胞工学 Volume: 30 Pages: 470-474
• [Journal Article] Behavioral profiles of three C57BL/6 sub strains (2010)
  • Author(s): Matsuo, N., Takao, K., Nakanishi, K., Yamasaki, N., Tanda, K., Miyakawa, T.
  • Journal Title: Front. Behav. Neurosci Volume: 4:29
  • DOI: 10.3389/fnbeh.2010.00029
  • Peer Reviewed
• [Journal Article] Behavioral profiles of three C57BL/6 substrains (2010)
  • Author(s): Naoki Matsuo
  • Journal Title: Front.Behav.Neurosci. Volume: 4
  • Peer Reviewed
• [Journal Article] Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice (2009)
  • Author(s): Matsuo N, Yamasaki N, Ohira K, Takao K, Toyama K, Eguchi M, Yamaguchi S, Miyakawa T
  • Journal Title: Front Behav Neurosci Volume: Vol.3 Pages: 20-20
  • DOI: 10.3389/neuro.08.020.2009
  • Peer Reviewed
• [Journal Article] Comprehensive behavioral phenotyping of ryanodine receptor type3(RyR3) knockout mice : decreased social contact duration in two social interaction tests (2009)
  • Author(s): Matsuo N, Tanda K, Nakanisi K, Yamasaki N, Toyama K, Takao K, Takeshima H, Miyakawa T
  • Journal Title: Front Behav Neurosci Volume: Vol.3 Pages: 3-3
  • DOI: 10.3389/neuro.08.003.2009
  • Peer Reviewed
• [Journal Article] 長期記憶の分子基盤 (2009)
  • Author(s): 松尾直毅
  • Journal Title: 生化学 81巻 Pages: 610-614
  • NAID: 10025188406
• [Journal Article] Comprehensive behavioral phenotyping of ryanodine receptor type3(RyR3)knockout mice (2009)
  • Author(s): 松尾直毅
  • Journal Title: Front.Behav.Neurosci. 3
  • Peer Reviewed
• [Journal Article] Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice (2009)
  • Author(s): Koichi Tanda
  • Journal Title: Mol.Brain 2
  • Peer Reviewed
• [Presentation] 遺伝子改変マウスを用いた記憶痕跡の探究 (2011)
  • Author(s): 松尾直毅
  • Organizer: 第82回日本動物学会シンポジウム
  • Place of Presentation: 旭川市
  • Year and Date: 2011-09-21
• [Presentation] 遺伝子改変マウスを用いた記憶痕跡の探究 (2011)
  • Author(s): 松尾直毅
  • Organizer: 第82回日本動物学会シンポジウム
  • Place of Presentation: 大雪クリスタルホール(旭川市)(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] 脳神経情報の階層的研究 (2011)
  • Author(s): 松尾直毅
  • Organizer: 自然科学研究機構シンポジウム
  • Place of Presentation: 岡崎市
  • Year and Date: 2011-02-23
• [Presentation] 記憶痕跡の探究 (2011)
  • Author(s): 松尾直毅
  • Organizer: 自然科学研究機構シンポジウム
  • Place of Presentation: 岡崎市(招待講演)
  • Year and Date: 2011-02-23
• [Presentation] Genetic Manipulation of Memory Circuits in Mice (2010)
  • Author(s): 松尾直毅
  • Organizer: 第33回日本分子生物学会年会シンポジウム
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-12-08
• [Presentation] Genetic Manipulation of Memory Circuits in Mice (2010)
  • Author(s): Naoki Matsuo
  • Organizer: 第33回日本分子生物学会年会 シンポジウム
  • Place of Presentation: 神戸市(招待講演)
  • Year and Date: 2010-12-08
• [Presentation] Genetic Silencing of Neuronal Ensembles in Mice (2010)
  • Author(s): 松尾直毅
  • Organizer: 生理研研究会
  • Place of Presentation: 岡崎市
  • Year and Date: 2010-12-02
• [Presentation] 記憶と学習の遺伝子研究 (2010)
  • Author(s): 松尾直毅
  • Organizer: 日本睡眠学会第15回睡眠科学研究講座
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-07-03
• [Presentation] 記憶と学習の遺伝子研究 (2010)
  • Author(s): 松尾直毅
  • Organizer: 日本睡眠学会 第15回 睡眠科学研究講座
  • Place of Presentation: 名古屋市(招待講演)
  • Year and Date: 2010-07-03
• [Presentation] Genetic Visualization of Memory in Mice (2009)
  • Author(s): 松尾直毅
  • Organizer: 第32回日本神経科学大会シンポジウム
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-18
• [Presentation] Genetic visualization of memory in mice (2009)
  • Author(s): Naoki Matsuo
  • Organizer: 第32回日本神経科学大会 シンポジウム
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-09-18
• [Book] 記憶の獲得と想起:記憶痕跡の解明に向けたアプローチ (2011)
  • Author(s): 松尾直毅
• [Book] 長期記憶の分子基盤 (2009)
  • Author(s): 松尾直毅
• [Book] 第2項試験法と結果の評価 (2009)
  • Author(s): 駒田致和、高雄啓三、松尾直毅、宮川剛
• [Remarks]
  • URL: http://www.cp.kyoto-u.ac.jp/Matsuo/Matsuo_Lab/Home.Html