| Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
|
|---|
| Research Abstract |
We recently reported a previously unknown peptidergic system within the lumbosacral spinal cord that uses gastrin-releasing peptide(GRP) to trigger erection and ejaculation in male rats. The identification of a male-specific neural system regulating sexual functions offers new avenues for potential therapeutic approaches to male reproductive dysfunction. Furthermore, this study demonstrated that the spinal GRP system appears to be a stress-vulnerable centre for male reproductive functions, which may provide new insight into a clinical target for the treatment of stress-related erectile dysfunction in men. More studies are needed at the molecular and behavioral levels to investigate the potential determinants of sexually dimorphic brain-spinal cord neural circuits and related clinical disorders in humans.
|
