Studies on the phosphorylation-mediated regulation of neural morphogenesis and its involvement in hydrocephalus
| Project/Area Number |
21680033
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2009: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Keywords | Fyn / RhoGAP / チロシンリン酸化 / シグナル伝達 / 水頭症 / 神経細胞 / 脳・神経 |
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| Research Abstract |
To make clear the molecular mechanisms of Fyn tyrosine kinase-mediated regulation of neural morphogenesis, I focused on TCGAP, one of Fyn substrates in the central nervous system. By analyzing TCGAP KO mice, I found that TCGAP regulated intracellular trafficking, spine morphogenesis, and dendrite morphogenesis. Together with the finding that TCGAP KO mice showed several behavioral abnormalities, Fyn-mediated phosphorylation of their substrates including TCGAP and p250GAP is necessary for higher brain functions.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases2012
Author(s)
Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, Macdonald JF
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Journal Title
EMBO J
Volume: 31(4)
Issue: 4
Pages: 805-816
DOI
Related Report
Peer Reviewed
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[Journal Article] NMDAR2B tyrosine phosphorylation modulates anxiety-like behavior by regulating CRF expression2010
Author(s)
Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T
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Journal Title
Mol. Brain
Volume: 3
Issue: 1
Pages: 37-37
DOI
Related Report
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[Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour2009
Author(s)
Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T
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Journal Title
EMBO J
Volume: 28(23)
Issue: 23
Pages: 3717-3729
DOI
Related Report
Peer Reviewed
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