Mechanism underlying the glucocorticoid-decreased function of neurotrophic factor in depression.

• Project/Area Number: 21680034
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: NUMAKAWA Tadahiro 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第3部, 室長 (40425690)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2009: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
• Keywords: 精神 / 神経疾患の病態と治療 / 神経科学 / 脳神経疾患 / 細胞・組織

Research Abstract

Following glucocorticoid(stress hormone) exposure, BDNF-dependent synaptic maturation was decreased in cultured cortical neurons. We found that shp2-TrkB interaction, which is important for BDNF-mediated synaptic protein expression, was also reduced. In vivo models, we examined possible change of BDNF-related intracellular signaling in forebrain after restraint stress. We found that significant GR downregulation after restraint operation and confirmed a decrease in BDNF-stimulated neurotransmitter release.

Research Products

• [Journal Article] Chronic restraint stress causes anxiety-and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex (2012)
  • Author(s): Chiba S, Numakawa T, Ninomiya M, Richards M, Wakabayashi C, Kunugi H
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Phencyclidine-induced decrease of synaptic connectivity via inhibition of BDNF secretion in cultured cortical neurons (2012)
  • Author(s): Adachi N, Numakawa T, Kumamaru E, Itami C, Chiba S, Iijima Y, Richards M, Katoh-Semba R, Kunugi H.
  • Journal Title: Cereb Cortex Volume: 23 Issue: 4 Pages: 847
  • DOI: 10.1093/cercor/bhs074
  • Peer Reviewed
• [Journal Article] Behavioral and molecular evidence for psychotropic effects in l-theanine (2012)
  • Author(s): Wakabayashi C, Numakawa T, Ninomiya M, Chiba S, Kunugi H.
  • Journal Title: Psychopharmacology(Berl) Volume: 219 Issue: 4 Pages: 1099
  • DOI: 10.1007/s00213-011-2440-z
  • Peer Reviewed
• [Journal Article] Growth factors stimulate expression of neuronal and glial miR-132 (2011)
  • Author(s): Numakawa T, Yamamoto N, Chiba S, Richards M, Ooshima Y, Kishi S, Hashido K, Adachi N, Kunugi H.
  • Journal Title: Neurosci. Lett Volume: 505 Issue: 3 Pages: 242
  • DOI: 10.1016/j.neulet.2011.10.025
  • Peer Reviewed
• [Journal Article] Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB (2011)
  • Author(s): Kumamaru E, Numakawa T, Adachi N, Kunugi H.
  • Journal Title: FEBS Lett Volume: 585 Issue: 20 Pages: 3224
  • DOI: 10.1016/j.febslet.2011.09.010
  • Peer Reviewed
• [Journal Article] MicroRNA function and neurotrophin BDNF (2011)
  • Author(s): Numakawa T, Richards M, Adachi N, Kishi S, Kunugi H, Hashido K.
  • Journal Title: Neurochem. Int Volume: 59 Issue: 5 Pages: 551
  • DOI: 10.1016/j.neuint.2011.06.009
  • Peer Reviewed
• [Journal Article] Protective action of neurotrophic factors and estrogen against oxidative stress-mediated neurodegeneration (2011)
  • Author(s): Numakawa T, Matsumoto T, Numakawa Y, Richards M, Yamawaki S, Kunugi H.
  • Journal Title: J. Toxicol Volume: 2011 Pages: 2011-405194
  • DOI: 10.1155/2011/405194
  • Peer Reviewed
• [Journal Article] Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF (2010)
  • Author(s): Ninomiya M, Numakawa T, Adachi N, Furuta M, Chiba S, Richards M, Shibata S, Kunugi H.
  • Journal Title: Neurosci Lett Volume: 476 Issue: 2 Pages: 104
  • DOI: 10.1016/j.neulet.2010.03.082
  • Peer Reviewed
• [Journal Article] Cabergoline, a dopamine receptor agonist, has an antidepressant-like property and enhances brain-derived neurotrophic factor signaling (2010)
  • Author(s): Chiba S, Numakawa T, Ninomiya M, Yoon HS, Kunugi H.
  • Journal Title: Psychopharmacology Volume: 211 Issue: 3 Pages: 291
  • DOI: 10.1007/s00213-010-1894-8
  • URL: https://pure.teikyo.jp/en/publications/d14f8943-819d-4211-bf5f-7d6be813ea70
  • Peer Reviewed
• [Journal Article] Functional interactions between steroid hormones and neurotrophin BDNF (2010)
  • Author(s): Numakawa T, Yokomaku D, Richards M, Hori H, Adachi N, Kunugi H.
  • Journal Title: World J. Biol. Chem Volume: 1 Issue: 5 Pages: 133-143
  • DOI: 10.4331/wjbc.v1.i5.133
  • Peer Reviewed
• [Journal Article] Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression (2010)
  • Author(s): Kunugi H, Hori H, Adachi N, Numakawa T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Issue: 5 Pages: 447
  • DOI: 10.1111/j.1440-1819.2010.02135.x
  • Peer Reviewed
• [Journal Article] BDNF function and intracellular signaling in neurons (2010)
  • Author(s): Numakawa T, Suzuki S, Kumamaru E, Adachi N, Richards M, Kunugi H.
  • Journal Title: Histology and Histopathology Volume: 25 Pages: 237-258
  • Peer Reviewed
• [Journal Article] SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression (2010)
  • Author(s): Tuerxun T, Numakawa T, Adachi N, Kumamaru E, Kitazawa H, Kudo M, Kunugi H.
  • Journal Title: Neuroscience Letters Volume: 469 Issue: 3 Pages: 303
  • DOI: 10.1016/j.neulet.2009.12.013
  • Peer Reviewed
• [Journal Article] Cyclophosphamide promotes cell survival via activation of intracellular signaling in cultured cortical neurons (2010)
  • Author(s): Kitazawa H, Numakawa T, Adachi N, Kumamaru E, Tuerxun T, Kudo M, Kunugi H.
  • Journal Title: Neuroscience Letters Volume: 470 Issue: 2 Pages: 139
  • DOI: 10.1016/j.neulet.2009.12.073
  • Peer Reviewed
• [Journal Article] Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. (2010)
  • Author(s): Kunugi H, Hori H, Adachi N, Numakawa T.
  • Journal Title: Psychiatry Clin.Neurosci. Volume: 64 Pages: 447-459
  • Peer Reviewed
• [Journal Article] Functional interactions between steroid hormones and neurotrophin BDNF. (2010)
  • Author(s): Numakawa T, Yokomaku D, Richards M, Hori H, Adachi N, Kunugi H.
  • Journal Title: World J.Biol.Chem. Volume: 1 Pages: 133-143
  • Peer Reviewed
• [Journal Article] Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF. (2010)
  • Author(s): Ninomiya M, Numakawa T, (他6名)
  • Journal Title: Neurosci Lett. Volume: 476 Pages: 104-109
  • Peer Reviewed
• [Journal Article] Cyclophosphamide pmmotes the cell survival via activation of intracellular signaling in cultured cortical neucons. (2010)
  • Author(s): Kitazawa H,Numakawa T, (他5名)
  • Journal Title: Neuroscience Letters 470 Pages: 139-144
  • Peer Reviewed
• [Journal Article] SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. (2010)
  • Author(s): Tuerxun T, Numakawa T, (他5名)
  • Journal Title: Neuroscience Letters 469 Pages: 303-308
  • Peer Reviewed
• [Journal Article] BDNF function and intracellular signaling in neurons (2010)
  • Author(s): Numakawa T, (他5名)
  • Journal Title: Histology and Histopathology 25 Pages: 237-258
  • Peer Reviewed
• [Journal Article] Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upreguladon of glutamate receptors via the suppression of microRNA-132 expression. (2010)
  • Author(s): Kawashima H, Numakawa T, (他6名)
  • Journal Title: Neuroscience 165 Pages: 1301-1311
  • Peer Reviewed
• [Presentation] 神経機能を変化させる神経栄養因子/ストレスの分子生物学的解析 (2012)
  • Author(s): 沼川忠広(Tadahiro Numakawa)
  • Organizer: 東邦大学
  • Place of Presentation: 千葉県船橋市東邦大学理学部第V号館(招待講演)
  • Year and Date: 2012-03-29
• [Presentation] 神経栄養因子とストレスホルモンの相互作用における細胞・分子生物学的解析 (2012)
  • Author(s): 沼川忠広(Tadahiro Numakawa)
  • Organizer: 武蔵野大学
  • Place of Presentation: 東京都武蔵野市武蔵野大学8号館(招待講演)
  • Year and Date: 2012-02-13
• [Presentation] Negative Effect of Glucocorticoids on Neuronal Function of Brain-derived Neurotrophic Factor (2012)
  • Author(s): Numakawa T, 他5名
  • Organizer: Neurotrophic Factor. BIT's 5th Anniversary of PepCon-2012
  • Place of Presentation: Beijing International Conve-ntion Center, Beijing, China
• [Presentation] Phencyclidine-Induced Synaptic Loss via Inhibition of BDNF Secretion in Cultured Cortical Neurons (2012)
  • Author(s): Adachi N, Numakawa T, 他7名
  • Organizer: BIT's 5th Anniversary of PepCon-2012
  • Place of Presentation: Beijing International Conve-ntion Center, Beijing, China
• [Presentation] Possible Involvement of miRNA-132 in Neuronal Function of Brain-derived Neurotrophic Factor (2012)
  • Author(s): Kishi S, Numakawa T, Adachi N, Kunugi H, Hashido K.
  • Organizer: BIT's 5th Anniversary of PepCon-2012
  • Place of Presentation: Beijing International Conve-ntion Center, Beijing, China
• [Presentation] Negative Effect of Glucocorticoids on Neuronal Function of Brain-derived Neurotrophic Factor (2012)
  • Author(s): Numakawa T, 他5名
  • Organizer: BIT's 5th Anniversary of PepCon-2012
  • Place of Presentation: Beijing International Convention Center, Beijing, China
• [Presentation] Phencyclidine-Induced Synaptic Loss via Inhibition of BDNF Secretion in Cultured Cortical Neurons (2012)
  • Author(s): Adachi N, Numakawa T, 他7名
  • Organizer: BIT's 5th Anniversary of PepCon-2012
  • Place of Presentation: Beijing International Convention Center, Beijing, China
• [Presentation] Possible Involvement of miRNA-132 in Neuronal Function of Brain-derived Neurotrophic Factor (2012)
  • Author(s): Kishi S, Numakawa T, Adachi N, Kunugi H, Hashido K
  • Organizer: BIT's 5th Anniversary of PepCon-2012
  • Place of Presentation: Beijing International Convention Center, Beijing, China
• [Presentation] Hypothalamic-pituitary-adrenal axis and depression : recent findings.視床下部-下垂体-副腎系とうつ病:最近の知見 (2011)
  • Author(s): 功刀浩(Hiroshi Kunugi), 堀弘明(Hiroaki Hori), 沼川忠広(Tadahiro Numakawa)
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京都新宿区京王プラザホテル(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] Crosstalk between neurotrophin BDNF and hypothalamic-pituitary-adrenal (HPA) axis.神経栄養因子BDNFとHPA系のクロストーク (2011)
  • Author(s): 沼川忠広(Tadahiro Numakawa), 安達直樹(Naoki Adachi), 功刀浩(Hiroshi Kunugi)
  • Organizer: 第54回日本神経化学会:日本神経化学会・日本生物学的精神医学会合同シンポジウム
  • Place of Presentation: 石川県加賀市山代温泉瑠璃光(招待講演)
  • Year and Date: 2011-09-27
• [Presentation] Estrogen receptorα-and BDNF-mediated intracellular signaling in anxiety-and depression-like behaviors in postpartum rats (2011)
  • Author(s): Furuta M, Numakawa T, 他6名
  • Organizer: Society for Neuroscience 2011
  • Place of Presentation: Walter E. Washington Convention Center. Washinton D. C., USA
• [Presentation] Interactions between Brain-derived neurotrophic factor and glucocorticoids (2011)
  • Author(s): Numakawa T, Adachi N, Kumamaru E, Kunugi H.
  • Organizer: BIT Life Sciences 4th Annual Protein and Peptide Conference
  • Place of Presentation: Beijing, China National Convention Center
• [Presentation] Possible involvement of brain-derived neurotrophic factor(BDNF) dysfunction in synaptic loss caused by phencyclidine (2011)
  • Author(s): Adachi N, Numakawa T, 他6名
  • Organizer: BIT Life Sciences 4th Annual Protein and Peptide Conference
  • Place of Presentation: Beijing, China National Convention Center
• [Presentation] Estrogen receptor α- and BDNF-mediated intracellular signaling in anxiety- and depression-like behaviors in postpartum rats (2011)
  • Author(s): Furuta M, Numakawa T, 他6名
  • Organizer: Society for Neuroscience 2011
  • Place of Presentation: Walter E. Washington Convention Center. Washinton D.C., USA
• [Presentation] Preventive effect by growth factors in suppression in neurotransmitter release after chronic glucocorticoid (2011)
  • Author(s): Numakawa T, 他5名
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] Suppression of BDNF secretion contributes to the phencyclidine-induced synaptic dysfunction (2011)
  • Author(s): Adachi N, Numakawa T, 他7名
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川県加賀市山代温泉瑠璃光
• [Presentation] Changes in emotional behaviors and the action of brain-derived neurotrophic factor in the prefrontal cortex after exposure to chronic restraint stress (2011)
  • Author(s): Chiba S, Numakawa T, 他5名
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川県加賀市山代温泉瑠璃光
• [Presentation] Possible involvement of dysfunction in BDNF function following phencyclidine exposure (2011)
  • Author(s): Adachi N, Numakawa T, 他7名
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市(パシフィコ横浜)
• [Presentation] Brain-specific microRNA-132 induction by growth factors in cortical neurons (2011)
  • Author(s): Yamamoto N, Numakawa T, 他5名
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市(パシフィコ横浜)
• [Presentation] Reduction in BDNF-induced neurotransmitter release in cultured cortical neurons from intrauterine growth retardation rats (2011)
  • Author(s): Oshima Y, Numakawa T, 他4名
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] BDNF- and estrogen receptor α-mediated intracellular signaling in anxiety- and depression-like behaviors in postpartum rats (2011)
  • Author(s): Furuta M, Numakawa T, 他7名
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] Interaction between miRNA-132 function and ERK signalings in BDNF-mediated synaptic function (2011)
  • Author(s): Kishi S, Numakawa T, 他4名
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] Behavioral and molecular evidence for psychotropic effects in 1-theanine. L-theanineの統合失調症治療に対する有用性の検討 (2011)
  • Author(s): 若林千里, 沼川忠広, 二宮碧, 千葉秀一, 功刀浩
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] BDNF依存的miR-132の発現増加へのグルココルチコイドの抑制的作用 (2011)
  • Author(s): 岸宗一郎、沼川忠広, 他4名
  • Organizer: 第30回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 京都府京都市京都ガーデンパレス
• [Presentation] Alteration by chronic restraint stress in anxiety- and depression-like behaviors, glucocorticoid receptor expression and BDNF-dependent neuronal function (2011)
  • Author(s): Chiba S, Numakawa T, 他5名
  • Organizer: 第32回内藤コンファレンス(Biological Basis of Mental Functions and Disorders)こころの機能と疾患の分子機構
  • Place of Presentation: 山梨県北杜市(八ヶ岳ロイヤルホテル)
• [Presentation] Phencyclidine-induced Synapse Loss through Impairment of BDNF Functi on in Cortical Neurons (2011)
  • Author(s): Adachi N, Numakawa T, 他7名
  • Organizer: 第32回内藤コンファレンス(Biological Basis of Mental Functions and Disorders)こころの機能と疾患の分子機構
  • Place of Presentation: 山梨県北杜市(八ヶ岳ロイヤルホテル)
• [Presentation] Interactions between Brain-derived neurotrophic factor and glucocorticoids. (2011)
  • Author(s): Numakawa T, Adachi N, Kumamaru E, Kunugi H.
  • Organizer: BIT Life Sciences' 4th Annual Protein and Peptide Conference
  • Place of Presentation: Beijing, China National Convention Center
• [Presentation] Possible involvement of brain-derived neurotrophic factor (BDNF) dysfunction in synaptic loss caused by phencyclidine. (2011)
  • Author(s): Adachi N, Numakawa T., (他6名)
  • Organizer: BIT Life Sciences' 4th Annual Protein and Peptide Conference
  • Place of Presentation: Beijing, China National Convention Center
• [Presentation] PHENCYCLIDINE DECREASES EXCITATORY SYNAPSES : POSSIBLE INVOLVEMENT OF DYSFUNCTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (2010)
  • Author(s): Adachi, N., Numakawa, T., 他6名
  • Organizer: The Asian-Pacific Society for Neurochemistry
  • Place of Presentation: Phuket Island, Thailand, Phuket Graceland Resort and Spa
• [Presentation] GLUCOCORTICOID SUPPRESSES BDNF-TRIGGERED GLUTAMATE RELEASE VIA DECREASING INTERACTION BETWEEN GLUCOCORTICOID RECEPTOR AND TRKB (2010)
  • Author(s): Numakawa, T., 他5名
  • Organizer: The Asian-Pacific Society for Neurochemistry
  • Place of Presentation: Phuket Island, Thailand, Phuket Graceland Resort and Spa
• [Presentation] bFGF reversed a suppression in BDNF-stimulated glutamate release caused by glucocorticoid exposure (2010)
  • Author(s): Numakawa T, Adachi N, Kumamaru E, Kunugi H
  • Organizer: Neuro2010(第33回日本神経科学大会.第53回日本神経化学会大会.第20回日本神経回路学会大会)
  • Place of Presentation: 兵庫県神戸市 神戸コンベンションセンター
• [Presentation] Phencyclidine decreases excitatory synaptic sites through suppression of BDNF secretion in cortical neurons (2010)
  • Author(s): 安達直樹、沼川忠広、熊丸絵美、伊丹千晶、仙波りつ子、功刀浩
  • Organizer: Neuro2010(第33回日本神経科学大会.第53回日本神経化学会大会.第20回日本神経回路学会大会)
  • Place of Presentation: 兵庫県神戸市 神戸コンベンションセンター
• [Presentation] Cultured neurons from intrauterine growth retardation rats display lower response to brain-derived neurotrophic factors. (2010)
  • Author(s): Ninomiya M, Numakawa T., (他6名)
  • Organizer: Neuro2010(第33回日本神経科学大会.第53回日本神経化学会大会.第20回日本神経回路学会大会)
  • Place of Presentation: 兵庫県神戸市 神戸コンベンションセンター
• [Presentation] Possible changes in neurotrophin signalings and levels of ERα are involved in anxiety- and depressive-like behaviors in postpartum rats after weaning. (2010)
  • Author(s): Furuta M, Numakawa T., (他7名)
  • Organizer: Neuro2010(第33回日本神経科学大会.第53回日本神経化学会大会.第20回日本神経回路学会大会)
  • Place of Presentation: 兵庫県神戸市 神戸コンベンションセンター
• [Presentation] Antidepressant- and Anxiolytic-like Properties of Dopamine Receptor Agonist Cabergoline (2010)
  • Author(s): Chiba S, Numakawa T, Ninomiya M, Kunugi H.
  • Organizer: Neuro 2010(第33回日本神経科学大会.第53回日本神経化学会大会.第20回日本神経回路学会大会)
  • Place of Presentation: 兵庫県神戸市 神戸コンベンションセンター
• [Presentation] グルココルチコイド受容体およびBDNF受容体の相互作用に制御されるグルタミン酸放出.(若手奨励賞シンポジウム) (2009)
  • Author(s): 沼川忠広
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬県渋川市(ホテル天坊)
• [Presentation] グルココルチコイド受容体およびBDNF受容体の相互作用に制御されるBDNF依存的グルタミン酸放出 (2009)
  • Author(s): 沼川忠広, (他5名)
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬県渋川市(ホテル天坊)
• [Presentation] 幼若期ニューロンヘのグルココルチコイド暴露はBDNFで増強されるシナプス成熟を抑制する (2009)
  • Author(s): 熊丸絵美、沼川忠広, (他3名)
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬県渋川市(ホテル天坊)
• [Presentation] フェンサイクリジンによる大脳皮質ニュー口ンのシナプス減少に、BDNFの分泌阻害が関与する (2009)
  • Author(s): 安達直樹、坦川墨広, (他4名)
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬県渋川市(ホテル天坊)
• [Presentation] シグマレセプターアゴニストSA4503は培養大脳皮質ニューロンにおいて生存維持効果を発揮する (2009)
  • Author(s): トルグントルスン、超川墨広, (他4名)
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬県渋川市(ホテル天坊)
• [Presentation] Glucocorticoid prevents BDNF-dependent up-regulation of glutamate receptors via the suppression of microRNA miR-132 expression. (2009)
  • Author(s): H Kawashima, T Numakawa, (他6名)
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市(パシフィコ横浜)
• [Book] 神経特異的microRNAと神経伝達Function of brain specific microRNA and neurotransmissionin specific microRNA and neurotransmission細胞工学 (2012)
  • Author(s): 沼川忠広,岸宗一郎,橋戸和夫
  • Publisher: 学研メディカル秀潤社
• [Book] 神経特異的microRNAと神経伝達Function of brain specific microRNA and neurotransmission (2012)
  • Author(s): 沼川忠広, 岸宗一郎, 橋戸和夫, 功刀浩
  • Total Pages: 4
  • Publisher: 学研メディカル秀潤社『細胞工学』
• [Book] 相互作用するストレスホルモン(グルココルチコイド)とBDNF機能 (2010)
  • Author(s): 沼川忠広、功刀浩
  • Publisher: 社団法人日本生化学会
• [Book] 治療抵抗性うつ病に対するドパミン受容体作動薬の有用性に関する検討 (2010)
  • Author(s): 功刀浩、千葉秀一、堀弘明、沼川忠広
  • Publisher: 医薬ジャーナル社
• [Book] 相互作用するストレスホルモン(グルココルチコイド)とBDNF機能(生化学) (2010)
  • Author(s): 沼川忠広、功刀浩
  • Total Pages: 4
  • Publisher: 社団法人日本生化学会
• [Book] 治療抵抗性うつ病に対するドパミン受容体作動薬の有用性に関する検討(Depression Frontier) (2010)
  • Author(s): 功刀浩、千葉秀一、堀弘明、沼川忠広
  • Total Pages: 6
  • Publisher: 医薬ジャーナル社
• [Book] 脳由来神経栄養因子(BDNF)の機能を抑制するストレスホルモン (2009)
  • Author(s): 沼川忠広、功刀浩
  • Publisher: 医歯薬出版株式会社
• [Book] グルココルチコイド受容体およびBDNF受容体の相互作用に制御されるグルタミン酸放出 (2009)
  • Author(s): 沼川忠広
  • Publisher: 神経化学会
• [Book] グルココルチコイド受容体およびBDNF受容体の相互作用に制御されるグルタミン酸放出.(Glucocorticoid receptor interdction with TrkB promotes BDNF-triggercd glutamate release.) (2009)
  • Author(s): 沼川忠広
  • Total Pages: 7
  • Publisher: 日本神経化学会
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r3/staff/numakawa.html
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r3/staff/numakawa.html
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r3/staff/numakawa.html
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r3/staff/numakawa.html