Integration of motor and reward information in direct and indirect pathways of basal ganglia
Project/Area Number |
21680036
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | Tamagawa University (2010-2011) The Institute of Physical and Chemical Research (2009) |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
Keywords | 神経科学 / 脳・神経 / 生理学 / 神経生理学 / ラット / 大脳皮質 / 運動野 / 神経細胞 |
Research Abstract |
The goal of our study is to elucidate the cellular mechanism of an integration of motor information and reward information in rat striatum. We performed a juxtacellular recording from single striatal neurons which were later stained for dopamine D1 receptors, and a multi-unit recording from many neurons in the motor cortex during forelimb movements. The striatal neurons showed motor-related activity that was positively modulated by reward information irrespective of the expression of D1 receptors. In contrast, only a few neurons showed such modulation in the motor cortex. These results suggest that the expression of dopamine D1 receptors does not determine the integration of motor and reward information in the motor cortex-basal ganglia loop.
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Report
(4 results)
Research Products
(22 results)