| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Research Abstract |
The goal of our study is to elucidate the cellular mechanism of an integration of motor information and reward information in rat striatum. We performed a juxtacellular recording from single striatal neurons which were later stained for dopamine D1 receptors, and a multi-unit recording from many neurons in the motor cortex during forelimb movements. The striatal neurons showed motor-related activity that was positively modulated by reward information irrespective of the expression of D1 receptors. In contrast, only a few neurons showed such modulation in the motor cortex. These results suggest that the expression of dopamine D1 receptors does not determine the integration of motor and reward information in the motor cortex-basal ganglia loop.
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