| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
By phenotype-driven ENU mutagenesis approach, we identified a S309T missense mutation in voltage-gated potassium channel, Kcna1 gene, which was the causative gene of human Episodic ataxia type1 (EA1). We have also identified a missense mutation in the gene associated with the oxidant stress as an epileptic rat model. By gene-driven ENU mutagenesis, we have generated Lgi1mutant (L385R) rats as a rat model for the human autosomal dominant lateral temporal lobe epilepsy (ADLTE). These epileptic rats are freely available from the National Bio-Resource Project for the rat in Japan.
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