Relationship between Biophysical Properties and Microstructure of Actin Stress Fibers
Project/Area Number |
21680039
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
|
Research Institution | Tohoku University |
Principal Investigator |
DEGUCHI Shinji 東北大学, 大学院・工学研究科, 准教授 (30379713)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
|
Keywords | ストレスファイバ / バイオメカニクス / メカノセンサー / メカノバイオロジー / 生物物理 / 細胞骨格 / 非筋アクトミオシン / メカノコントローラー / 生物物理学 / 細胞バイオメカニクス / 生体医工学 / ストレスファイバー / 非筋II型ミオシン / メカノセンサ |
Research Abstract |
Stress fibers play a key role in regulation of cell homeostasis. Here we investigated their biophysical properties and microstructure. Particularly, we developed a method to isolate stress fibers that are intact with regard to structure (confirmed by western blotting and electron microscopy)and function(confirmed by a contractility assay). We then submitted a molecular mechanism that may underlie the cell shortening-induced disassembly of stress fibers.
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Report
(4 results)
Research Products
(58 results)