| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2009: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Research Abstract |
In order to prepare bone specific polymer biomaterials, we have synthesized polyphosphoester ionomers and compared their fundamental actions with bisphosphonates. The adsorption amount of polyphosphoester ionomers on hydroxy apatite(HAp) microparticles was increased with an increase in the ionized units in polyphosphoesters and the affinity of ionomers for HAp microparticles was enhanced by formation of sodium salt. Polyphosphoesters ionomers could significantly reduce HAp-formation compared with pamidronate. Moreover, the resorption of HAp was also reduced with addition of polyphosphoester ionomers as a similar to pamidronate. The cytotoxicity of polyphosphoester ionomers was significantly lower than that of pamidronate and cell compatibility of the ionomer further improved by sodium salt formation of the polyphosphoester ionomers. Furthermore, the increment in ALP activity and mineral deposition of mouse osteoblast cells in contact with ionomers was observed.
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