| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
In Japanese, the frequency of drug-induced severe lung injury is quite higher than that of other species. The aim of this study is to create practical and reliable information about prevention of drug-induced lung injury on the basis of the pharmacokinetic profiles of food factors. Amiodarone is a potent drug used in the treatment of serious supraventricular and ventricular tachyarrhythmias. However, its wide clinical use and long-lasting administration are precluded by extensive adverse effects such as interstitial pneumonia. We have found that amiodarone induces organic anion transporter (OATP2B1) expression at the alveolar epithelium and intestinal membrane and enhances absorption of organic anion compounds.
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