Prevention of drug-induced lung injury on the basis of the pharmacokinetic profiles of food factors
| Project/Area Number |
21680051
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Hirosaki University (2010-2011)
Hokkaido University (2009) |
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Principal Investigator |
ITAGAKI Shiro 弘前大学, 医学部・附属病院, 准教授 (00360925)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | OATP2B1 / アミオダロン / 取り込み促進 / 発現促進 / 肺障害 / A549 / ルテイン / コレステロール / NPC1L1 / 肺胞上皮細胞 / 分化 / 単層膜 / トランスポーター / 医薬品適正使用 / OATP / 薬物動態 / 体内動態 |
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| Research Abstract |
In Japanese, the frequency of drug-induced severe lung injury is quite higher than that of other species. The aim of this study is to create practical and reliable information about prevention of drug-induced lung injury on the basis of the pharmacokinetic profiles of food factors. Amiodarone is a potent drug used in the treatment of serious supraventricular and ventricular tachyarrhythmias. However, its wide clinical use and long-lasting administration are precluded by extensive adverse effects such as interstitial pneumonia. We have found that amiodarone induces organic anion transporter (OATP2B1) expression at the alveolar epithelium and intestinal membrane and enhances absorption of organic anion compounds.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Involvement of cholesterol membrane transporter Niemann-Pick C1-Like 1 in the intestinal absorption of lutein2012
Author(s)
Sato, Y., Suzuki, R., Kobayashi, M., Itagaki, S., Hirano, T., Noda, T., Mizuno, S., Sugawara, M. and Iseki, K
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Journal Title
J. Pharm. Pharmaceut. Sci
Volume: 15
Pages: 256-264
Related Report
Peer Reviewed
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