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Development of micro tissue devices using cardiovascular cells

Research Project

Project/Area Number 21681019
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Microdevices/Nanodevices
Research InstitutionThe Institute of Physical and Chemical Research (2011-2013)
The University of Tokyo (2009-2010)

Principal Investigator

TANAKA Yo  独立行政法人理化学研究所, 生命システム研究センター, ユニットリーダー (40532271)

Project Period (FY) 2009-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Keywordsマイクロバイオシステム / マイクロ・ナノデバイス / 細胞・組織 / 再生医学 / 生体機能利用 / 生物・生体工学 / 細胞パターニング / マイクロポンプ
Research Abstract

Recently, integration of chemical process such as analysis and synthesis has been focused on. For further integration, peripheral tools such as pumps is also indispensable to be integrated. However, mechanical devices usually require electricity, and thus, current technology has a limitation of integration. On the other hand, cardiovascular cells or tissue are really integrated components with sophisticated chemical and mechanical functions in micro size. By exploiting this, ultra highly integrated microfluidic devices will be realized. Based on this concept, new conceptual bio-microdevices were developed by sophistically combining microstructures and cell/tissue functions in this project.

Report

(5 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (105 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (46 results) (of which Peer Reviewed: 46 results) Presentation (55 results) (of which Invited: 1 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] A peristaltic pump integrated on a 100% glass microchip using computer controlled piezoelectric actuators2014

    • Author(s)
      Yo Tanaka
    • Journal Title

      Micromachines

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electric actuating valves incorporated into an all glass-based microchip exploiting the flexibility of ultra thin glass2013

    • Author(s)
      Yo Tanaka
    • Journal Title

      RSC Advances

      Volume: 3(26) Pages: 10213-10220

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An active valve incorporated into a microchip using a high strain electroactive polymer2013

    • Author(s)
      Yo Tanaka, Tomohiro Fujikawa, Yutaka Kazoe, Takehiko Kitamori
    • Journal Title

      Sensors and Actuators B : Chemical

      Volume: 184(31) Pages: 163-169

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Totally glass-based microchips with valves and pumps using flexibility of ultra thin glass2013

    • Author(s)
      Yo Tanaka
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2013

      Pages: 1475-1477

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shallow antibody-coated microchannel based selective cell capture and analysis2013

    • Author(s)
      Yo Tanaka, Kihoon Jang, Jun Wakabayashi, Reina Ishii, Kae Sato, Kazuma Mawatari, Mats Nilsson, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2013

      Pages: 359-361

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An active valve incorporated into a microchip using a high strain electroactive polymer2013

    • Author(s)
      Yo Tanaka, Tomohiro Fujikawa, Yutaka Kazoe, Takehiko Kitamori
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 184(31) Pages: 163-169

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Totally glass based microchips with valves and pumps using flexibility of ultra thin glass2013

    • Author(s)
      Yo Tanaka
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2013

      Volume: 1 Pages: 1475-1477

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective cell capture and analysis using shallow antibody-coated microchannels2012

    • Author(s)
      Kihoon Jang, Yo Tanaka, Jun Wakabayashi, Reina Ishii, Kae Sato, Kazuma Mawatari, Mats Nilsson, Takehiko Kitamori
    • Journal Title

      Biomicrofluidics

      Volume: 6(4) Pages: 44117-44117

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microchip-based cellular biochemical systems for practical applications and fundamental research : from microfluidics to nanofluidics2012

    • Author(s)
      Yan Xu, Kihoon Jang, Tadahiro Yamashita, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 402(1) Pages: 99-107

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] All glass-based actuator for valves and pumps using ultra thin glass membrane and piezo actuators2012

    • Author(s)
      Yo Tanaka
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2012

      Pages: 1273-1275

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Creation of a cell-based separation microdevice using human renal proximal tubule epithelial cells2012

    • Author(s)
      Xiaofang Gao, Kazuma Mawatari, Yutaka Kazoe, Yo Tanaka, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2012

      Pages: 602-604

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smooth muscle cell culture in microchannel toward construction of multilayered vascular tissue in micro-scale2012

    • Author(s)
      Tadahiro Yamashita, Kazuma Mawatari, Yo Tanaka, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2012

      Pages: 1708-1710

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microchip-based cellular biochemical systems for practical applications and fundamental research : from microfluidics to nanofluidics2012

    • Author(s)
      Y.Xu
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 402 Pages: 99-107

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluid actuation for a bio-micropump powered by previously frozen cardiomyocytes directly seeded on a diagonally stretched thin membrane2011

    • Author(s)
      Yo Tanaka, Yuka Yanagisawa, Takehiko Kitamori
    • Journal Title

      Sensors and Actuators B, Chemical

      Volume: 156(1) Pages: 494-498

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a confluent cardiomyocyte culture in a cylindrical microchannel2011

    • Author(s)
      Yo Tanaka, Hiroto Akaike, Yasuhiko Sugii, Takehiko Kitamori
    • Journal Title

      Analytical Sciences

      Volume: 27(9) Pages: 957-960

    • NAID

      10029761268

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basic structure and cell culture condition of a bioartificial renal tubule on chip towards cell-based separation microdevice2011

    • Author(s)
      Xiaofang Gao, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
    • Journal Title

      Analytical Sciences

      Volume: 27(9) Pages: 907-911

    • NAID

      10029761042

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of microfluidic platform for single-cell analysis using a direct photoactive cell-attaching method2011

    • Author(s)
      Kihoon Jang, Hong Trang Thi Ngo, Yo Tanaka, Yan Xu, Kazuma Mawatari, Takehiko Kitamori
    • Journal Title

      Analytical Sciences

      Volume: 27(10) Pages: 973-978

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multistep mixing, reaction and detection system in an extended-nano fluidic network2011

    • Author(s)
      Yo Tanaka, Hong Trang Ngo, Yutaka Kazoe, Hisashi Shimizu, Kazuma Mawatari, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2011

      Pages: 380-382

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis2011

    • Author(s)
      Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2011

      Pages: 1032-1034

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes2011

    • Author(s)
      Yo Tanaka, Yuka Yanagisawa, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2011

      Pages: 1846-1848

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip2011

    • Author(s)
      Tadahiro Yamashita, Yo Tanaka, Naokazu Idota, Kae Sato, Kazuma Mawatari, Takehiko Kitamori
    • Journal Title

      Biomaterials

      Volume: 32(10) Pages: 2459-2465

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluid actuation for a bio-micropump powered by previously frozen cardiomyocytes directly seeded on a diagonally stretched thin membrane2011

    • Author(s)
      Y.Tanaka
    • Journal Title

      Sensors and Actuators B, Chemical

      Volume: 156 Pages: 494-498

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a confluent cardiomyocyte culture in a cylindrical microchannel2011

    • Author(s)
      Y.Tanaka
    • Journal Title

      Analytical Sciences

      Volume: 27 Pages: 957-960

    • NAID

      10029761268

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic structure and cell culture condition of a bioartificial renal tubule on chip towards cell-based separation microdevice2011

    • Author(s)
      X.Gao
    • Journal Title

      Analytical Sciences

      Volume: 27 Pages: 907-911

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of microfluidic platform for single-cell analysis using a direct photoactive cell-attaching method2011

    • Author(s)
      K.Jang
    • Journal Title

      Analytical Sciences

      Volume: 27 Pages: 907-911

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multistep mixing, reaction and detection system in an extended-nano fluidic network2011

    • Author(s)
      Y.Tanaka
    • Journal Title

      Proc.Micro Total Analysis Systems 2011

      Pages: 380-382

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis2011

    • Author(s)
      K.Shirai
    • Journal Title

      Proc.Micro Total Analysis Systems 2011

      Pages: 1032-1034

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes2011

    • Author(s)
      Y.Tanaka
    • Journal Title

      Proc.Micro Total Analysis Systems 2011

      Pages: 1846-1848

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip2011

    • Author(s)
      T.Yamashita
    • Journal Title

      Biomaterials

      Volume: 32 Pages: 2459-2465

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluid actuation for a bio-micropump powered by previously frozen cardiomyocytes directly seeded on a diagonally stretched thin membrane2011

    • Author(s)
      Y.Tanaka
    • Journal Title

      Sensors and Actuators B : Chemical

      Volume: (印刷中(掲載確定))

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An efficient surface modification by 2-methacryloyloxyethyl phosphorylcholine for selective control of cell attachment using photochemical reaction in microchannel2010

    • Author(s)
      Kihoon Jang, Kae Sato, Yo Tanaka, Yan Xu, Kazuma Mawatari, Moritoshi Sato, Takahiro Nakajima, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori
    • Journal Title

      Lab on a Chip

      Volume: 10(15) Pages: 1937-1945

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell attachment and culture method using a photochemical reaction in a closed microfluidic system2010

    • Author(s)
      Kihoon Jang, Yan Xu, Yo Tanaka, Kae Sato, Kazuma Mawatari, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori
    • Journal Title

      Biomicrofluidics

      Volume: 4(3) Pages: 32208-32208

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of insulin delivery devices composed of Langerhans islets and cardiomyocytes2010

    • Author(s)
      Hiroto Akaike, Yo Tanaka, Yasuhiko Sugii, Takahiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2010

      Pages: 2017-2019

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of vascular-mimetic tissue in a separable microchip2010

    • Author(s)
      Tadahiro Yamashita, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2010

      Pages: 1316-1318

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] An efficient surface modification using 2-methacryloyloxyethyl phosphorylcholine to control cell attachment via photochemical reaction in a microchannel2010

    • Author(s)
      K.Jang
    • Journal Title

      Lab on a Chip

      Volume: 10 Pages: 1937-1945

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell attachment and culture method using a photochemical reaction in a closed microfluidic system2010

    • Author(s)
      K.Jang
    • Journal Title

      Biomicrofluidics

      Volume: 4 Pages: 32208-32208

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of insulin delivery devices composed of Langerhans islets and cardiomyocytes2010

    • Author(s)
      H.Akaike
    • Journal Title

      Proc.Micro Total Analysis Systems 2010

      Pages: 2017-2019

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of vascular-mimetic tissue in a separable microchip2010

    • Author(s)
      T.Yamashita
    • Journal Title

      Proc.Micro Total Analysis Systems 2010

      Pages: 2017-2019

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An efficient surface modification by 2-methacryloyloxyethyl phosphorylcholine for selective control of cell attachment using photochemical reaction in microchannel2010

    • Author(s)
      K.Jang, K.Sato, Y.Tanaka, Y.Xu, K.Mawatari, M.Sato, T.Nakajima, T.Konno, K.Ishihara, T.Kitamori
    • Journal Title

      Lab on a Chip (印刷中(掲載確定))

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assembly and simple demonstration of a micropump installing PDMS-based thin membranes as flexible micro check valves2009

    • Author(s)
      Yo Tanaka, Kae Sato, Takehiko Kitamori
    • Journal Title

      Journal of Biomedical Nanotechnology

      Volume: 5(5) Pages: 516-520

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recovery and manipulation system of vascular tissue cultured in a separable microchip2009

    • Author(s)
      Tadahiro Yamashita, Yo Tanaka, Kae Sato, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2010

      Pages: 1832-1834

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells2009

    • Author(s)
      Kihoon Jang, Kae Sato, Yo Tanaka, Takahiro Nakajima, Moritoshi Sato, Takehiko Kitamori
    • Journal Title

      Proceeding of Micro Total Analysis Systems 2010

      Pages: 1907-1909

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assembly and simple demonstration of a micropump installing PDMS-based thin membranes2009

    • Author(s)
      Y.Tanaka, K.Sato, T.Kitamori
    • Journal Title

      Journal of Boimedical Nanotechnology 5

      Pages: 516-520

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recovery and manipulation system of vascular tissue cultured in a separable microchip2009

    • Author(s)
      T.Yamashita, Y.Tanaka, K.Sato, T.Kitamori
    • Journal Title

      Proceedings of Micro Total Analysis Systems 2009 2

      Pages: 1832-1834

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells2009

    • Author(s)
      K.Jang, K.Sato, Y.Tanaka, T.Nakazima, M.Sato, T.Kitamori
    • Journal Title

      Proceedings of Micro Total Analysis Systems 2009 2

      Pages: 1907-1909

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A peristaltic pump integrated on a 100% glass microchip using computer controlled piezoelectric actuators

    • Author(s)
      Yo Tanaka
    • Journal Title

      Micromachines

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Microfluidic devices in totally glass microchips using flexible ultra thin glass2014

    • Author(s)
      Yo Tanaka
    • Organizer
      2014 EMN Summer meeting (Energy Material Nanotechnology)
    • Place of Presentation
      The Westin Resort & Spa, Cancun, Mexico
    • Year and Date
      2014-06-09
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] An active valve incorporated into a microchip using a high strain electroactive polymer2014

    • Author(s)
      Yo Tanaka
    • Organizer
      BIT's 3rd Annual Conference and EXPO of AnalytiX 2014
    • Place of Presentation
      Dalian World Expo Center, China
    • Year and Date
      2014-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] An active valve incorporated into a microchip using a high strain electroactive plymer2014

    • Author(s)
      Yo Tanaka
    • Organizer
      BIT's 3rd Annual Conference and EXPO of AnalytiX 2014
    • Place of Presentation
      Dalian World Expo Center, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Totally glass-based microchips with valves and pumps using flexibility of ultra thin glass2013

    • Author(s)
      Yo Tanaka
    • Organizer
      17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Freiburg, Germany
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Shallow antibody-coated microchannel based selective cell capture and analysis2013

    • Author(s)
      Yo Tanaka, Kihoon Jang, Jun Wakabayashi, Reina Ishii, Kae Sato, Kazuma Mawatari, Mats Nilsson, Takehiko Kitamori
    • Organizer
      17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Freiburg, Germany
    • Year and Date
      2013-10-28
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] All glass-based actuator for valves and pumps using ultra thin glass membrane and piezo actuators2012

    • Author(s)
      Yo Tanaka
    • Organizer
      16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2012-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Creation of a cell-based separation microdevice using human renal proximal tubule epithelial cells2012

    • Author(s)
      Xiaofang Gao, Kazuma Mawatari, Yutaka Kazoe, Yo Tanaka, Takehiko Kitamori
    • Organizer
      16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2012-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Multistep mixing, reaction and detection system in an extended-nano fluidic network2011

    • Author(s)
      Y.Tanaka
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis2011

    • Author(s)
      K.Shirai
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes2011

    • Author(s)
      Y.Tanaka
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes2011

    • Author(s)
      Yo Tanaka, Yuka Yanagisawa, Takehiko Kitamori
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis2011

    • Author(s)
      Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Multistep mixing, reaction and detection system in an extended-nano fluidic network2011

    • Author(s)
      Yo Tanaka, Hong Trang Ngo, Yutaka Kazoe, Hisashi Shimizu, Kazuma Mawatari, Takehiko Kitamori
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Construction of a cell-based separation microdevice using renal tubule cells cultured on chip2011

    • Author(s)
      高小放, 田中陽, 杉井康彦, 馬渡和真, 北森武彦
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Construction of a cell-based separation microdevice using renal tubule cells cultured on chip2011

    • Author(s)
      X.Gao
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structure and cell culture condition for miniaturization of a bioartificial renal tubule on chip2011

    • Author(s)
      高小放, 田中陽, 杉井康彦, 馬渡和真, 北森武彦
    • Organizer
      第23回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      千葉
    • Year and Date
      2011-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Structure and cell culture condition for miniaturization of a bioartificial renal tubule on chip2011

    • Author(s)
      X.Gao
    • Organizer
      第23回化学とマイクロ・ナノシステム研究会(CHEMINAS)
    • Place of Presentation
      千葉大学西千葉キャンパス
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of interface between micro and extended-nano spaces for femtoliter scale analysis of single cells2011

    • Author(s)
      Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
    • Organizer
      International Symposium on Microchemistry and Microsystems 2011 (ISMM)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-06-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of interface between micro and extended-nano spaces for femtoliter scale analysis of single cells2011

    • Author(s)
      K.Shirai
    • Organizer
      International Symposium on Microchemistry and Microsystems 2011 (ISMM 2011)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Design and initial test of a bioartificial renal tuble on chip2011

    • Author(s)
      Xiaofang Gao, Yo Tanaka, Yasuhiko Sugii, Takehiko Kitamori
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011 (ICAS)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Design and initial test of a bioartificial renal tuble on chip2011

    • Author(s)
      X.Gao
    • Organizer
      IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-05-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Single cell analysis at femtoliter scale utilizing extended-nano space2011

    • Author(s)
      Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
    • Organizer
      2nd Annual Single Cell Analysis Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2011-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Single cell analysis at femtoliter scale utilizing extended-nano space2011

    • Author(s)
      K.Shirai
    • Organizer
      2nd annual Single Cell Analysis Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Study on the culturing condition and recovery of smoth muscle cels in a separable microchip2010

    • Author(s)
      Tadahiro Yamashita, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
    • Organizer
      6th International Chemical Congress of Pacific Basin Societies Sponsors (PACIFICHEM)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of a self-perfusion micro insulin pump powered by cardiomyocytes2010

    • Author(s)
      Hiroto Akaike, Yo Tanaka, Yasuhiko Sugii, Takehiko Kitamori
    • Organizer
      6th International Chemical Congress of Pacific Basin Societies Sponsors (PACIFICHEM)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Study on the culturing condition and recovery of smooth muscle cells in a separable microchip2010

    • Author(s)
      T.Yamashita
    • Organizer
      International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of a self-perfusion micro insulin pump powered by cardiomyocytes2010

    • Author(s)
      H.Akaike
    • Organizer
      International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Creation of cell-based separation microdevices : design and initial test of a bioartificial kidney on chip2010

    • Author(s)
      X.Gao
    • Organizer
      10th Asian-Pacific International Symposium on Microscale Separations and Analysis (APCE 2010)
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Creation of cell-based separation microdevices : Design and initial test of a bioartificial kidney on chip2010

    • Author(s)
      Xiaofang Gao, Yo Tanaka, Yasuhiko Sugii, Takehiko Kitamori
    • Organizer
      10th Asian-Pacific International Symposium on Microscale Separations and Analysis (APCE)
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Creation of cell-based separation microdevices : design and initial test of a bioartificial kidney (BAK) microchip2010

    • Author(s)
      高小放, 田中陽, 杉井康彦, 北森武彦
    • Organizer
      第22回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Creation of cell-based separation microdevices : design and initial test of abioartificial kidney (BAK) microchip2010

    • Author(s)
      X.Gao
    • Organizer
      第22回化学とマイクロ・ナノシステム研究会(CHEMINAS)
    • Place of Presentation
      名古屋大学医学部附属病院
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of insulin delivery devices composed of Langerhans islets and cardiomyocytes2010

    • Author(s)
      Hiroto Akaike, Yo Tanaka, Yasuhiko Sugii, Takahiko Kitamori
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Groningen, Netherland
    • Year and Date
      2010-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Construction of vascular-mimetic tissue in a separable microchip2010

    • Author(s)
      Tadahiro Yamashita, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Groningen, Netherland
    • Year and Date
      2010-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of insulin delivery devices composed of Langerhansislets and cardiomyocytes2010

    • Author(s)
      H.Akaike
    • Organizer
      14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Groningen, Netherland
    • Year and Date
      2010-10-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Construction of vascular-mimetic tissue in a separable microchip2010

    • Author(s)
      T.Yamashita
    • Organizer
      14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Groningen, Netherland
    • Year and Date
      2010-10-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multi-patterning of biological samples on glass substrate and inside the fused microchannel by using photochemical reaction2010

    • Author(s)
      Kihoon Jang, Yan Xu, Yo Tanaka, Takehiko Kitamori
    • Organizer
      17th International Symposium on Capillary Electroseparation Techniques (ITP)
    • Place of Presentation
      Baltimore, Maryland
    • Year and Date
      2010-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Multi-patterning of biological samples on glass substrate and inside the fused microchannel by using photochemical reaction2010

    • Author(s)
      K.Jang
    • Organizer
      17th International Symposium on Electro- and Liquid Phase-separation Techniques (ITP 2010)
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心筋細胞を用いた自己灌流マイクロインスリンポンプの開発2010

    • Author(s)
      高小放, 田中陽, 杉井康彦, 北森武彦
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 分離型マイクロ化学チップ内での血管平滑筋細胞の培養条件の検討2010

    • Author(s)
      山下忠紘, 田中陽, 杉井康彦, 馬渡和真, 北森武彦
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 心筋細胞を用いた自己灌流マイクロインスリンポンプの開発2010

    • Author(s)
      赤池寛人
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会(CHEMINAS)
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分離型マイクロ化学チップ内での血管平滑筋細胞の培養条件の検討2010

    • Author(s)
      山下忠紘
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会(CHEMINAS)
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Culture and recovery of smooth muscle cells in a separable microchip for the construction of micro-scale vascular tissue2010

    • Author(s)
      Tadahiro Yamashita, Yo Tanaka, Takehiko Kitamori
    • Organizer
      International Symposium on Microchemistry and Microsystems (ISMM) 2010
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-05-29
    • Related Report
      2013 Final Research Report
  • [Presentation] A method for single cell patterning by using photochemical reaction in fused microchannel2010

    • Author(s)
      Kihoon Jang, Yan Xu, Yo Tanaka, Takehiko Kitamori
    • Organizer
      International Symposium on Microchemistry and Microsystems (ISMM) 2010
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-05-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Culture and recovery of smooth muscle cells in a separable microchip for the construction of micro-scale vascular tissue2010

    • Author(s)
      T.Yamashita
    • Organizer
      International Symposium on Microchemistry and Microsystems 2010 (ISMM 2010)
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] A method for single cell patterning by using photochemical reaction infused micrcoahnnel2010

    • Author(s)
      K.Jang
    • Organizer
      International Symposium on Microchemistry and Microsystems 2010 (ISMM 2010)
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Single cell patterning in semi-closed microchannel using photoactivation2010

    • Author(s)
      Kihoon Jang, Yan Xu, Yo Tanaka, Takehiko Kitamori
    • Organizer
      25th International Symposium on Microscale Bioseapartions (MSB)
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2010-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Single cell patterning in semi-closed microchannel using photoactivation2010

    • Author(s)
      K.Jang, Y.Xu, Y.Tanaka, T.Kitamori
    • Organizer
      25th International Symposium on MicroScale Bioseparations and Methods for Systems Biology(MSB)
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2010-03-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Recovery and manipulation system of vascular tissue cultured in a separable microchip2009

    • Author(s)
      Tadahiro Yamashita, Yo Tanaka, Kae Sato, Takehiko Kitamori
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells2009

    • Author(s)
      Kihoon Jang, Kae Sato, Yo Tanaka, Takahiro Nakajima, Moritoshi Sato, Takehiko Kitamori
    • Organizer
      15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Recovery and manipulation system of vascular tissue cultured in a separable microchip2009

    • Author(s)
      山下忠紘、田中陽、佐藤香枝、北森武彦
    • Organizer
      12th International Conference on Miniaturized Chemical and Biochemical Analysis Systems(μTAS)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells2009

    • Author(s)
      K.Jang, K.Sato, Y.Tanaka, T.Nakazima, M.Sato, T.Kitamori
    • Organizer
      12th International Conference on Miniaturized Chemical and Biochemical Analysis Systems(μTAS)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endothelial cell-piccell co-culture microfluidic system for indication of nitric oxide2009

    • Author(s)
      Kihoon Jang, Kae Sato, Yo Tanaka, Takahiro Nakazima, Moritoshi Sato, Takehiko Kitamori
    • Organizer
      24th International Symposium on MicroScale Bioseparations and Methods for Systems Biology (MSB)
    • Place of Presentation
      Dalian, China
    • Year and Date
      2009-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Endothelial cell-piccell co-culture microfluidic system for indication of nitric oxide2009

    • Author(s)
      K.Jang, K.Sato, Y.Tanaka, T.Nakazima, M.Sato, T.Kitamori
    • Organizer
      24th International Symposium on MicroScale Bioseparations and Methods for Systems Biology(MSB)
    • Place of Presentation
      Dalian, China
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分離型マイクロ化学チップによる血管組織の構築と回収2009

    • Author(s)
      山下忠紘, 田中陽, 佐藤香枝, 北森武彦
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-05-29
    • Related Report
      2013 Final Research Report 2009 Annual Research Report
  • [Presentation] Nitric oxide indicator based on microfluidic co-culture system2009

    • Author(s)
      張氣薫, 佐藤香枝, 田中陽, 中嶋隆浩, 佐藤守俊, 北森武彦
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-05-29
    • Related Report
      2013 Final Research Report 2009 Annual Research Report
  • [Remarks] 研究代表者(PI)研究室ホームページ

    • URL

      http://www.qbic.riken.jp/ibd/jpn/

    • Related Report
      2013 Final Research Report
  • [Remarks] 集積バイオデバイス研究ユニットホームページ

    • URL

      http://www.qbic.riken.jp/ibd/jpn/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] Fluid-controlling device for microchip and use thereof2013

    • Inventor(s)
      Yo Tanaka, Hiroki R. Ueda
    • Industrial Property Rights Holder
      RIKEN
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-02
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Fluid-controlling device for microchip and use thereof2013

    • Inventor(s)
      Yo Tanaka, Hiroki R. Ueda
    • Industrial Property Rights Holder
      理化学研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-02
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2019-07-29  

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