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Molecular Neuroethological Approach for Understanding Species-Specific Learned Vocal Patterns

Research Project

Project/Area Number 21681024
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field 基礎ゲノム科学
Research InstitutionHokkaido University

Principal Investigator

WADA Kazuhiro  北海道大学, 大学院・理学研究院, 准教授 (70451408)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords音声発声学習 / ソングバード / 遺伝子発現 / 神経伝達物質受容体 / 発声学習 / 種特異的行動 / 進化 / 発声行動 / 動物行動 / 発声パターン / プロモーター
Research Abstract

In this study, we tried to elucidate molecular basis for evolution of behavior, especially in species-specific learned vocal patterns in songbirds. For the purpose, we focused on the relationship of genes which had species-specific regulation in song system and species-specific song patterns. So far, we performed to construct a molecular phylogenetic tree and extract species-specific song features with a novel song analysis method. Furthermore, we succeeded to elucidate genes which had which had species-specific expression patterns and levels in song system among 10 Asian songbird species using DNA microarray. Now, we are trying to adult adeno-associate virus expression system into songbird brain to over-or down-regulation of genes which are regulated with species-specific manner.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (62 results)

All 2012 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (47 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue2012

    • Author(s)
      Chen C, Wada K, Jarvis, ED
    • Journal Title

      Journal of Visualized Experiments

      Volume: Vol.62

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radioactive in-situ hybridization in avian embryonic tissues2012

    • Author(s)
      Chen, C.-C., Wada, K., Erich D.Jarvis, ED
    • Journal Title

      JoVE

      Volume: (掲載確定)(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト以外の動物にことばはあるか:ヒトの言語とソングバードの囀り2011

    • Author(s)
      森千紘, 和多和宏
    • Journal Title

      JOHN

      Volume: Vol.27 Pages: 1161-1168

    • Related Report
      2011 Final Research Report
  • [Journal Article] 聴覚入力による音声パターン学習・維持の神経機構:学習で獲得された発声パターンはいかに維持されるか?2011

    • Author(s)
      堀田悠人, 和多和宏
    • Journal Title

      実験医学

      Volume: Vol.29 Pages: 544-550

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] ヒト以外の動物にことばはあるか:ヒトの言語とソングバードの囀り2011

    • Author(s)
      森千紘, 和多和宏
    • Journal Title

      JOHNS

      Volume: 27 Pages: 1161-1168

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Dopamine receptors in a songbird brain2010

    • Author(s)
      Kubikova L, Wada K, Jarvis ED
    • Journal Title

      Journal of Comparative Neurology

      Volume: Vol.518 Pages: 741-69

    • NAID

      120002317144

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The dusp1 Immediate Early Gene is Regulated by Natural Stimuli Predominantly in Sensory Input Neurons2010

    • Author(s)
      Horita H, Wada K, Rivas MV, Hara E, Jarvis ED
    • Journal Title

      Journal of Comparative Neurology

      Volume: Vol.518 Pages: 2873-2901

    • NAID

      120002317143

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ソングバードの囀りを制御する神経回路・遺伝子2010

    • Author(s)
      今井礼夢, 森千紘, 和多和宏
    • Journal Title

      生物の科学遺伝

      Volume: Vol.64 Pages: 40-47

    • Related Report
      2011 Final Research Report
  • [Journal Article] ソングバードの囀りを制御する神経回路・遺伝子2010

    • Author(s)
      今井礼夢、森千紘、和多和宏
    • Journal Title

      生物の科学 遺伝

      Volume: 64 Pages: 40-47

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Dopamine receptors in a songbird brain.2010

    • Author(s)
      Kubikova L, Wada K, Jarvis ED.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 518 Pages: 741-769

    • NAID

      120002317144

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variable food begging calls are harbingers of vocal learning2009

    • Author(s)
      Liu WC, Wada K, Nottebohm F
    • Journal Title

      PLoS ONE

      Volume: Vol.16

    • NAID

      120002414855

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variable food begging calls are harbingers of vocal learning.2009

    • Author(s)
      Liu WC, Wada K, Nottebohm F.
    • Journal Title

      PLoS ONE.

      Volume: 16

    • NAID

      120002414855

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小鳥のさえずりパターンにおける種特異的拘束2012

    • Author(s)
      今井礼夢、和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      大雪クリスタルホール(旭川市)
    • Year and Date
      2012-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epigenetic gene expression dynamics induced by singing regulate a critical period of vocal learning2011

    • Author(s)
      Masahiko Kobayashi, Raimu Imai, Chihiro Mori, Eri Ohgushi, Haruhito Horita, Wan-chun Liu, Kazuhiro Wada
    • Organizer
      Neuroscience 2011, Society for Neuroscience
    • Place of Presentation
      Washigton DC convention center (USA)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Restricted learning of heterospecific song in zebra finch2011

    • Author(s)
      R Imai, K Wada
    • Organizer
      Neuroscience 2011, Society for Neuroscience
    • Place of Presentation
      Washigton DC convention center (USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Deafening before critical period of vocal learning causes delayed stabilization of vocal patter2011

    • Author(s)
      Mori C, Liu WC, Wada K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC Convention Center、USA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Restricted learning of heterospecific song in zebra finch2011

    • Author(s)
      Imai R, Wada K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC Convention Center、USA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Epigenetic gene expression dynamics induced by singing regulate a critical period of vocal learning2011

    • Author(s)
      Kobayashi M, Imai R, Mori C, Ohgushi E, Horita H, LiuW-C, Wada K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC Convention Center、USA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Deafening before critical period of vocal learning causes delayed stabilization of vocal patter2011

    • Author(s)
      Chihiro Mori, Wan-chun Liu, Kazuhiro Wada
    • Organizer
      Neuroscience 2011, Society for Neuroscience
    • Place of Presentation
      Washigton DC convention center (USA)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経行動科学から考える「生まれと育ち」2011

    • Author(s)
      和多和宏
    • Organizer
      ASCON
    • Place of Presentation
      諏訪市かたくら諏訪湖ホテル
    • Year and Date
      2011-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経行動科学から考える「生まれと育ち」2011

    • Author(s)
      和多和宏
    • Organizer
      ASCON
    • Place of Presentation
      かたくら諏訪湖ホテル(諏訪市)(招待講演)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ホルモン投与による囀り行動の制御とその囀り発達への影2011

    • Author(s)
      生田麻実、森千紘、和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      大雪クリスタルホール(旭川市)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 囀り学習臨界期中の囀り頻度は囀り日内発達に影響を与える2011

    • Author(s)
      大串恵理、和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      大雪クリスタルホール(旭川市)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発声学習臨界期における多段階発現制御機構とエピジェネティクス動態2011

    • Author(s)
      和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 小鳥のさえずりパターンにおける種特異的拘束2011

    • Author(s)
      森千紘・和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ホルモン投与による囀り行動の制御とその囀り発達への影2011

    • Author(s)
      生田麻実・森千紘・和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 囀り学習臨界期中の囀り頻度は囀り日内発達に影響を与える2011

    • Author(s)
      大串恵理・和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川大雪クリスタルホール
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 発声学習臨界期における多段階発現制御機構とエピジェネティクス動態2011

    • Author(s)
      和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      大雪クリスタルホール(旭川市)(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 聴覚入力阻害による囀りパターン固定化への影響2011

    • Author(s)
      森千紘, 和多和宏
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      大雪クリスタルホール(旭川市)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小鳥の囀り学習過程における種特異的な囀りパターンの発達変化2011

    • Author(s)
      森千紘・和多和宏
    • Organizer
      日本神経科学会第34回大会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 小鳥の囀り学習過程における種特異的な囀りパターンの発達変2011

    • Author(s)
      森千紘, 和多和宏
    • Organizer
      日本神経科学会第34回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小鳥の囀り学習過程における種特異的な囀りパターンの発達変化2011

    • Author(s)
      今井礼夢、和多和宏
    • Organizer
      日本神経科学会第34回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 聴覚入力阻害による囀りパターン固定化への影響2011

    • Author(s)
      森千紘・和多和宏
    • Organizer
      日本動物心理学会・日本動物行動学会・応用動物行動学会・日本家畜管理学会合同大会
    • Place of Presentation
      東京慶應義塾大学三田キャンパス
    • Year and Date
      2011-09-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 聴覚入力阻害による囀りパターン固定化への影響2011

    • Author(s)
      森千紘, 和多和宏
    • Organizer
      日本動物心理学会・日本動物行動学会・応用動物行動学会・日本家畜管理学会合同大会
    • Place of Presentation
      慶應義塾大学三田キャンパス(東京都)
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発声行動依存的に誘導されるエピジェネティックな脳内遺伝子発現調節が音声発声学習の臨界期制御に関与する2011

    • Author(s)
      小林雅比古・今井礼夢・森千紘・Wan-chun Liu・和多和宏
    • Organizer
      日本エピジェネティクス研究会
    • Place of Presentation
      熊本KKRホテル熊本
    • Year and Date
      2011-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 発声行動依存的に誘導されるエピジェネティックな脳内遺伝子発現調節が音声発声学習の臨界期制御に関与する2011

    • Author(s)
      小林雅比古・今井礼夢・森千紘・Wan-chun Liu・和多和宏
    • Organizer
      日本エピジェネティクス研究会
    • Place of Presentation
      KKRホテル熊本(熊本県)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経行動科学から考える「生まれと育ち」2011

    • Author(s)
      和多和宏
    • Organizer
      脳と心のメカニズム(第11回冬のワークショップ)
    • Place of Presentation
      留寿都ルフツリゾートホテル
    • Year and Date
      2011-01-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経行動科学から考える「生まれと育ち」2011

    • Author(s)
      和多和宏
    • Organizer
      脳と心のメカニズム(第11回冬のワークショップ)
    • Place of Presentation
      ルスツ
    • Year and Date
      2011-01-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression dynamics of epigenetics-related genes developmentally regulated by singing behavior2010

    • Author(s)
      Masahiko Kobayashi, Raimu Imai, Chihiro Mori, Haruhito Horita, Wan-chun Liu, Kazuhiro Wada
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Deafening before critical period for vocal learning affects gene expression pattern in song nuclei of songbird.2010

    • Author(s)
      Chihiro Mori, Kazuhiro Wada
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differential expression pattern of singing induced Egr family through sensorimotor period of song learning.2010

    • Author(s)
      Raimu Imai, Ohgushi Eri, Kazuhiro Wada
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Specialized motor-driven dusp1 expression in song nuclei of vocal learning birds2010

    • Author(s)
      Horita H, Kobayashi M, Jarvis E, Oka K, Wada K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, USA
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Deafening before critical period for vocal learning affects gene expression pattern in song nuclei of songbird2010

    • Author(s)
      Mori C, Wada K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, USA
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Differential expression pattern of singing induced Egr family through sensorimotor period of song learning2010

    • Author(s)
      Imai R, Ohgushui E, Wada K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, USA
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Repeated evolution of activity-dependent motor-driven dusp1 expression in song nuclei of vocal learning birds2010

    • Author(s)
      Haruhito Horita, Masahiko Kobayashi, Kotaro Oka, Erich D.Jarvis, Kazuhiro Wada
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Specialized motor-driven dusp1 expression in song nuclei of vocal learning birds.2010

    • Author(s)
      Haruhito Horita,, Masahiko Kobayashi, Erich D.Jarvis, Kotaro Oka, Kazuhiro Wada
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] キンカチョウの囀り行動頻度による囀り発達の影響2010

    • Author(s)
      大串恵理、和多和宏
    • Organizer
      日本動物学会 北海道支部
    • Place of Presentation
      旭川
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 囀り行動によって発現誘導されるエピジェネティクス関連遺伝子群の学習臨 界期中の発現変化2010

    • Author(s)
      小林雅比古、和多和宏
    • Organizer
      日本動物学会 北海道支部
    • Place of Presentation
      旭川
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 音声発声学習における聴覚入力阻害による行動発達への影響2010

    • Author(s)
      森千紘、和多和宏
    • Organizer
      日本動物学会 北海道支部
    • Place of Presentation
      旭川
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規音声時系列構造の開発2010

    • Author(s)
      今井礼夢、和多和宏
    • Organizer
      日本動物学会 北海道支部
    • Place of Presentation
      旭川
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発声行動依存的に誘導されるエピジェネティクス関連遺伝子ヒストンH3. 3の学習臨界期間における脳内発現変化2010

    • Author(s)
      小林雅比古・和多和宏
    • Organizer
      日本エピジェネティクス研究会
    • Place of Presentation
      鳥取米子市文化ホール
    • Year and Date
      2010-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 発声行動依存的に誘導されるエピジェネティクス関連遺伝子ピストンH3.3の学習臨界期間における脳内発現変化2010

    • Author(s)
      小林雅比古、和多和宏
    • Organizer
      日本エピジェネティクス研究会
    • Place of Presentation
      鳥取
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Auditory deprivation affects gene expression in vocal related pathway in songbird2009

    • Author(s)
      森千紘・和多和宏
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Multiple regulation of Egr family expression for vocal learning in songbird2009

    • Author(s)
      今井礼夢・和多和宏
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Immediate Early Gene dusp1 is Regulated by Natural Behavior in the Primary Sensory Areas and Vocal Areas of Birds2009

    • Author(s)
      堀田悠人・Jarvis ED・岡浩太郎・和多和宏
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Auditory deprivation affects gene expression in vocal related pathway in songbird2009

    • Author(s)
      森千紘・和多和宏
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multiple regulation of Egr family expression for vocal learning in songbird2009

    • Author(s)
      今井礼夢・和多和宏
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immediate Early Gene dusp1 is Regulated by Natural Behavior in the Primary Sensory Areas and Vocal Areas of Birds2009

    • Author(s)
      堀田悠人・Erich D Jarvis・岡浩太郎・和多和宏
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] キンカチョウ歌生成へRA神経細胞自発発火の及ぼす影響2009

    • Author(s)
      安島綾子・今井礼夢・森千紘・和多和宏・Neal A.Hessler
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Book] 行動遺伝学入門:動物とヒトの"こころ"の科学2011

    • Author(s)
      小出剛・山元大輔
    • Publisher
      裳華房
    • Related Report
      2011 Final Research Report
  • [Book] 行動遺伝学入門2011

    • Author(s)
      小出剛・山元大輔編著
    • Total Pages
      217
    • Publisher
      裳華房
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.wada-lab.org/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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