Encapsulation of a Biomolecule in a Hollow of a Self-Assembled Metal-Organic Complex
| Project/Area Number |
21685007
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Inorganic chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
SATO Sota The University of Tokyo, 大学院・工学系研究科, 講師 (40401129)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2010: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
|
|---|
| Keywords | 超分子錯体 / 自己組織化 / 錯体 / ユビキチン / 中空カプセル / パラジウム / 球状錯体 / ペプチド |
|---|
| Research Abstract |
An artificial, well-defined spherical molecules were self-assembled from 72 building blocks with the diameter of several nanometers. The number of components, 72, was the world largest number, and the huge molecular structure was clearly determined. The complex was very stable because of the large number of components, and we succeeded to link biomolecules to the spherical skeleton. The large size of the self-assembled spheres is very original and attractive : (1) an encapsulation of one protein inside the sphere, (2) decollation of peptide chains, and (3) surface modification with DNA were achieved to show functions due to their characteristic molecular structures.
|
Report
(3 results)
Research Products
(44 results)
