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Encapsulation of a Biomolecule in a Hollow of a Self-Assembled Metal-Organic Complex

Research Project

Project/Area Number 21685007
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Inorganic chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

SATO Sota  The University of Tokyo, 大学院・工学系研究科, 講師 (40401129)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2010: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Keywords超分子錯体 / 自己組織化 / 錯体 / ユビキチン / 中空カプセル / パラジウム / 球状錯体 / ペプチド
Research Abstract

An artificial, well-defined spherical molecules were self-assembled from 72 building blocks with the diameter of several nanometers. The number of components, 72, was the world largest number, and the huge molecular structure was clearly determined. The complex was very stable because of the large number of components, and we succeeded to link biomolecules to the spherical skeleton. The large size of the self-assembled spheres is very original and attractive : (1) an encapsulation of one protein inside the sphere, (2) decollation of peptide chains, and (3) surface modification with DNA were achieved to show functions due to their characteristic molecular structures.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (44 results)

All 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (33 results) Remarks (5 results)

  • [Journal Article] Well-Defined DNA Nanoparticles Templated by Self-Assembled M_<12>L_<24> Molecular Spheres and Binding of Complementary Oligonucleotides2010

    • Author(s)
      T.Kikuchi, S.Sato, M.Fujita
    • Journal Title

      J.Am.Chem.Soc. 132

      Pages: 15930-15932

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide-coated, Self-assembled M_<12>L_<24> Coordination Spheres and Their Immobilization onto an Inorganic Surface2010

    • Author(s)
      M.Ikemi, T.Kikuchi, S.Matsumura, K.Shiba, S.Sato, M.Fujita
    • Journal Title

      Chem.Sci. 1

      Pages: 68-71

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-Assembled M24L48 Polyhedra and Their Sharp Structural Switch upon Subtle Ligand Variation2010

    • Author(s)
      Q.-F.Sun, J.Iwasa, D.Ogawa, Y.Ishido, S.Sato, T.Ozeki, Y.Sei, K.Yamaguchi, M.Fujita
    • Journal Title

      Science 328

      Pages: 1144-1147

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-Assembled M_<24>L_<48> Polyhedra and Their Sharp Structural Switch upon Subtle Ligand Variation2010

    • Author(s)
      Q.-F.Sun, J.Iwasa, D.Ogawa, Y.Ishido, S.Sato, T.Ozeki, Y.Sei, K.Yamaguchi, M.Fujita
    • Journal Title

      Science

      Volume: 328 Pages: 1144-1147

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide-coated, Self-assembled M_<12>L_<24> Coordination Spheres and Their Immobilization onto an Inorganic Surface2010

    • Author(s)
      M.Ikemi, T.Kikuchi, S.Matsumura, K.Shiba, S.Sato, M.Fujita
    • Journal Title

      Chem.Sci.

      Volume: 1 Pages: 68-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Well-Defined DNA Nanoparticles Templated by Self-Assembled M_<12>L_<24> Molecular Spheres and Binding of Complementary Oligonucleotides2010

    • Author(s)
      T.Kikuchi, S.Sato, M.Fujita
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 132 Pages: 15930-15932

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ペプチド修飾球状錯体の高い基板認識能を利用したタンパク質の固定2011

    • Author(s)
      池見昌敏・菊池貴・南澤宝美后・松村幸子・芝清隆・佐藤宗太・藤田誠
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウイルス-インスパイアード多成分球状錯体の自己組織化構築2011

    • Author(s)
      孫慶福・村瀬隆史・佐藤宗太・藤田誠
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] M_<24>L_<48>自己組織化球状錯体の内面官能基修飾2011

    • Author(s)
      岩佐淳司・佐藤宗太・藤田誠
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自己集合性球状錯体表面におけるDNA認識2011

    • Author(s)
      菊池貴・佐藤宗太・芝清隆・藤田誠
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] M_<12>L_<24>球状錯体へのAbetaペプチドの包接2011

    • Author(s)
      藤田大士・佐藤宗太・矢木真穂・山口拓実・加藤晃一・藤田誠
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] M_nL_<2n>白金球状錯体の自己組織化における速度論および熱力学支配2011

    • Author(s)
      高橋麻奈・藤田大士・佐藤宗太・藤田誠
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自己集合性ボウル型錯体を用いたオリゴペプチドのヘリックス構造の誘起2011

    • Author(s)
      久田隼人・池見昌敏・菊池貴・佐藤宗太・藤田誠
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of multi-component self-assembled coordination spheres and biological applications2010

    • Author(s)
      SATO, Sota Sun Qing-Fu Iwasa, Junji, Kikuchi, Takashi Ikemi, Masatoshi, FUJITA, Makoto
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      ホノルル・ハワイ州・アメリカ合衆国にて
    • Year and Date
      2010-12-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis of multi-component self-assembled coordination spheres and biological applications2010

    • Author(s)
      SATO, Sota Sun Qing-Fu Iwasa, Junji, Kikuchi, Takashi Ikemi, Masatoshi, FUJITA, Makoto
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      ホノルル・ハワイ州・アメリカ合衆国
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Peptide-coated, self-assembled M_<12>L_<24> coordination spheres and their immobilization onto an inorganic surface2010

    • Author(s)
      M.Ikemi ; T.Kikuchi ; S.Matsumura ; K.Shiba ; S.Sato ; M.Fujita
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      ホノルル・ハワイ州・アメリカ合衆国
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Construction of a water-soluble M_<12>L_<24> spherical complex with sugar coating2010

    • Author(s)
      A.Takahashi ; D.Fujita ; S.Sato ; M.Fujita
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      ホノルル・ハワイ州・アメリカ合衆国
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Construction of nanoscopic phases within M_<12>L_<24> coordination spheres2010

    • Author(s)
      K.Takao ; K.Suzuki ; S.Sato ; M.Fujita
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      ホノルル・ハワイ州・アメリカ合衆国
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ペプチド修飾M_<12>L_<24>球状錯体の自己組織化構築と基板表面修飾2010

    • Author(s)
      池見昌敏・菊池貴・松村幸子・芝清隆・佐藤宗太・藤田誠
    • Organizer
      第4回生体関連化学シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] M_<12>L_<24>球状錯体の内部空間を利用したナノサイズ溶媒相の構築2010

    • Author(s)
      高尾清貴・鈴木康介・佐藤宗太・藤田誠
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] M_<12>L_<24>/M_<24>L_<48>球状錯体の創発的自己組織化:構成成分の微小変化が生み出す劇的構造変化2010

    • Author(s)
      岩佐淳司・孫慶福・佐藤宗太・藤田誠
    • Organizer
      第21回基礎有機化学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Integration of bioactive oligo-saccharides on the surface of an M_<12>L_<24> spherical complex2010

    • Author(s)
      FUJITA, Daihi ; SATO, Sota ; YAGI, Maho ; YAMAGUCHI, Takumi ; KATO, Koichi ; FUJITA, Makoto
    • Organizer
      ISMSC2010
    • Place of Presentation
      奈良
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Peptide-coated, Self-assembled M_<12>L_<24> Coordination Spheres and Their Immobilization onto an Inorganic Surface2010

    • Author(s)
      Masatoshi Ikemi, Takashi Kikuchi, Sachiko Matsumura, Kiyotaka Shiba, Sota Sato, Makoto Fujita
    • Organizer
      ISMSC2010
    • Place of Presentation
      奈良
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA-coated, Self-assembled Coordination Nanospheres and Their Recognition Ability for Complementary Strand2010

    • Author(s)
      Takashi KIKUCHI, Sota SATO, Yoshihisa SEI, Kentaro YAMAGUCHI, Makoto FUJITA
    • Organizer
      ISMSC2010
    • Place of Presentation
      奈良
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Self-Assembled M_<24>L_<48> Polyhedra andtheir Sharp Structural Switch upon Subtle Ligand Variation2010

    • Author(s)
      Qing-Fu Sun, Junji Iwasa, Sota Sato, Makoto Fujita
    • Organizer
      ISMSC2010
    • Place of Presentation
      奈良
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Construction of a Water-soluble M_<12>L_<24> Spherical Complex with Sugar Coating2010

    • Author(s)
      TAKAHASHI, Asana ; FUJITA, Daishi ; SATO, Sota ; FUJITA, Makoto
    • Organizer
      ISMSC2010
    • Place of Presentation
      奈良
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Construction of Nanoscopic Phases within M_<12>L_<24> Coordination Spheres2010

    • Author(s)
      Kiyotaka Takao, Kosuke Suzuki, Sota Sato, Makoto Fujita
    • Organizer
      ISMSC2010
    • Place of Presentation
      奈良
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖鎖修飾による水溶性M12L24球状錯体の合成2010

    • Author(s)
      高橋麻奈・藤田大士・佐藤宗太・藤田誠
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生理活性糖を精密集積したM12L24球状錯体の合成2010

    • Author(s)
      藤田大士・佐藤宗太・矢木真穂・山口拓実・加藤晃一・藤田誠
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 巨大中空構造を持つM24L48球状錯体の自己組織化構築2010

    • Author(s)
      孫慶福・佐藤宗太・尾関智二・清悦久・山口健太郎・藤田誠
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非対称なM12L23L'球状錯体の合成2010

    • Author(s)
      石堂由高・佐藤宗太・藤田誠
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ペプチドを用いたM12L24球状錯体の無機基板への固定2010

    • Author(s)
      池見昌敏・菊池貴・佐藤宗太・松村幸子・芝清隆・藤田誠
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] オリゴヌクレオチド修飾M12L24球状錯体による相補配列の認識2010

    • Author(s)
      菊池貴・佐藤宗太・清悦久・山口健太郎・藤田誠
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reactions in a Hollow of Self-Assembled Nano Capsule2009

    • Author(s)
      S.Sato, M.Fujita
    • Organizer
      The 5th Sino-Japanese Symposium on Organic Chemistry for Young Scientists
    • Place of Presentation
      成都,中国
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reactions in a Hollow of Self-Assembled Nano Capsule2009

    • Author(s)
      S.Sato, M.Fujita
    • Organizer
      The 5th Sino-Japanese Symposium on Organic Chemistry for Young Scientists
    • Place of Presentation
      成都・中国にて
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] M12L24球状錯体表面のオリゴヌクレオチド修飾と相補鎖認識2009

    • Author(s)
      菊池貴・佐藤宗太・清悦久・山口健太郎・藤田誠
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自己集合性錯体へのユビキチンの内包2009

    • Author(s)
      藤田大士・鈴木康介・佐藤宗太・山口芳樹・栗本英治・山口拓実・加藤晃一・藤田誠
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Encapsulation of Ubiquitin into a Self-assembled Coordination Sphere2009

    • Author(s)
      藤田大士・鈴木康介・佐藤宗太・山口芳樹・栗本英治・山口拓実・加藤晃一・藤田誠
    • Organizer
      ISMSC2009
    • Place of Presentation
      Maastricht, The Netherlands
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Remarkable Stability of M12L24 Spherical Complexes2009

    • Author(s)
      石堂由高・佐藤宗太・藤田誠
    • Organizer
      ISMSC2009
    • Place of Presentation
      Maastricht, The Netherlands
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://fujitalab.t.u-tokyo.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://d.hatena.ne.jp/TodaiGCOE/20100616

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.u-tokyo.ac.jp/public/pdf/220430.pdf

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://fujitalab.t.u-tokyo.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://fujitalab.t.u-tokyo.ac.jp/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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