| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Research Abstract |
We have demonstrated that the substrate specificity of cytochrome P450s can be altered by inducing their substrate misrecognition using a decoy molecule that has a structural similarity to those of natural substrate. Accordingly, we have succeeded in constructing a novel reaction system that catalyzes oxidation reactions of non-natural substrates without any mutagenesis. Notably, our reaction system can alter the enantioselectivity of products just by changing the structure of the decoy molecules.
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