| Budget Amount *help |
¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
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| Research Abstract |
The cooperative catalysis by palladium and triphenylborane effects the intramolecular oxycyanation and aminocyanation of alkenes through the cleavage of O-CN bonds and the subsequent insertion of double bonds. The use of 4, 5-bis(diphenylphosphino)-9, 9dimethylxanthene(Xantphos) as a ligand for palladium is essential for allowing the transformation to proceed with high chemo and regioselectivity. Variously substituted dihydrobenzofurans with both a tetrasubstituted carbon and cyano functionality, which are often found in biologically active substances including some pharmaceuticals, are accessed by the newly developed methodology in a highly efficient manner.
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