Development of bio-actuator constructed by magnetic force-based tissue engineering

• Project/Area Number: 21686079
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Biofunction/Bioprocess
• Research Institution: Kyushu University
• Principal Investigator: ITO Akira Kyushu University, 大学院・工学研究院, 准教授 (60345915)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: ティッシュエンジニアリング / 磁性ナノ粒子 / バイオアクチュエータ / 骨格筋 / 筋芽細胞 / 筋組織 / アクチュエータ / 磁性粒子 / リポソーム / マグネタイト

Research Abstract

If an artificial skeletal muscle can be applied as an actuator, it may exhibit high energy conversion efficiency. In this study, we successfully constructed three-dimensional tissue-like structures composed of myoblast cells by using a magnetic force-based tissue engineering technique. The tissue contracted rhythmically in response to electrical pulses. Moreover, we constructed genetically engineered myoblast cells to promote their performance as bio-actuator.

Research Products

• [Journal Article] Functional Evaluation of Artificial Skeletal Muscle Tissue Constructs Fabricated by a Magnetic Force-Based Tissue Engineering Technique. (2011)
  • Author(s): Yasunori Yamamoto, Akira Ito, Hideaki Fujita, Eiji Nagamori, Yoshinori Kawabe, Masamichi Kamihira
  • Journal Title: Tissue Engineering Part A 17(1-2) Pages: 107-114
  • NAID: 120004979405
  • Peer Reviewed
• [Journal Article] Functional evaluation of artificial skeletal muscle tissue constructs fabricated by a magnetic force-based tissue engineering technique. (2011)
  • Author(s): Yasunori Yamamoto, et al.
  • Journal Title: Tissue Engineering Part A Volume: 17 Pages: 107-114
  • Peer Reviewed
• [Journal Article] Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique. (2010)
  • Author(s): Hirokazu Akiyama, Akira Ito, Masanori Sato, Yoshinori Kawabe, Masamichi Kamihira
  • Journal Title: International Journal of Molecular Sciences 11(8) Pages: 2910-2920
  • NAID: 120005227380
  • Peer Reviewed
• [Journal Article] Genetically Engineered Angiogenic Cell Sheets Using Magnetic Force-Based Gene Delivery and Tissue Fabrication Techniques. (2010)
  • Author(s): Hirokazu Akiyama, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira
  • Journal Title: Biomaterials 31(6) Pages: 1251-1259
  • NAID: 120005289501
  • Peer Reviewed
• [Journal Article] Construction of cardiac tissue rings using a magnetic tissue fabrication technique. (2010)
  • Author(s): Hirokazu Akiyama, et al.
  • Journal Title: International Journal of Molecular Sciences Volume: 11 Pages: 2910-2920
  • Peer Reviewed
• [Journal Article] Genetically engineered angiogenic cell sheets using magnetic force-based gene delivery and tissue fabrication techniques. (2010)
  • Author(s): Hirokazu Akiyama, et al.
  • Journal Title: Biomaterials 31 Pages: 1251-1259
  • Peer Reviewed
• [Presentation] Construction of skeletal muscular tissue-like structures by a magnetic force-based tissue engineering technique (2010)
  • Author(s): Yasunori Yamamoto, et al.
  • Organizer: APBioChEC2009
  • Place of Presentation: 神戸市
  • Year and Date: 2010-11-26
• [Presentation] Fabrication of Artificial Skeletal Muscle Tissues by a Magnetic Force-Based Tissue Engineering Technique. (2010)
  • Author(s): Yasunori Yamamoto, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira
  • Organizer: The 16th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2010)
  • Place of Presentation: 元智大学(台湾)
  • Year and Date: 2010-11-10
• [Presentation] Fabrication of artificial skeletal muscle tissues by a magnetic force-based tissue engineering technique (2010)
  • Author(s): Yasunori Yamamoto, et al.
  • Organizer: The 16th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2010)
  • Place of Presentation: 元智大学(台湾)
  • Year and Date: 2010-11-10
• [Presentation] Fabrication of Angiogenic Gene-Modified Myoblast Cell Sheets Using Magnetic Tissue Engineering Techniques. (2010)
  • Author(s): Hirokazu Akiyama Akira Ito, Yoshinori Kawabe, Masamichi Kamihira
  • Organizer: International Conference on Chemical Engineering 2010
  • Place of Presentation: サンフランシスコ(アメリカ)
  • Year and Date: 2010-10-21
• [Presentation] Fabrication of angiogenic gene-modified myoblast cell sheets using magnetic tissue engineering techniques (2010)
  • Author(s): Hirokazu Akiyama, et al.
  • Organizer: International conference on chemical engineering 2010
  • Place of Presentation: サンフランシスコ(アメリカ)
  • Year and Date: 2010-10-21
• [Presentation] Magnetic Force-Based Tissue Engineering of Skeletal Muscle. (2010)
  • Author(s): Yasunori Yamamoto, Akira Ito, Hideaki Fujita, Eiji Nagamori, Yoshinori Kawabe, Masamichi Kamihira
  • Organizer: 14th International Biotechnology Symposium and Exhibition
  • Place of Presentation: リミニ(イタリア)
  • Year and Date: 2010-09-14
• [Presentation] Magnetic force-based tissue engineering of skeletal muscle (2010)
  • Author(s): Yasunori Yamamoto, et al.
  • Organizer: 14th International Biotechnology Symposium and Exhibition
  • Place of Presentation: リミニ(イタリア)
  • Year and Date: 2010-09-14
• [Presentation] IGF-I遺伝子導入による高機能筋芽細胞の作製 (2010)
  • Author(s): 佐藤暢哲, 井藤彰, 河邉佳典, 長森英二, 上平正道
  • Organizer: 化学工学会第42回秋季大会
  • Place of Presentation: 同志社大学(京都市)
  • Year and Date: 2010-09-06
• [Presentation] ティッシュエンジニアリングによる筋組織構築とバイオアクチュエータへの応用 (2010)
  • Author(s): 井藤彰, 河邉佳典, 長森英二, 上平正道
  • Organizer: 化学工学会第42回秋季大会
  • Place of Presentation: 同志社大学(京都市)
  • Year and Date: 2010-09-06
• [Presentation] ティッシュエンジニアリングによる筋組織構築とバイオアクチュエータへの応用 (2010)
  • Author(s): 井藤彰、河邉佳典、長森英二、上平正道
  • Organizer: 化学工学会 第42回秋季大会
  • Place of Presentation: 同志社大学(京都市)
  • Year and Date: 2010-09-06
• [Presentation] IGF-I遺伝子導入による高機能筋芽細胞の作製 (2010)
  • Author(s): 佐藤暢哲、井藤彰、河邉佳典、長森英二、上平正道
  • Organizer: 化学工学会 第42回秋季大会
  • Place of Presentation: 同志社大学(京都市)
  • Year and Date: 2010-09-06
• [Presentation] バイオアクチュエータのためのIGF-I遺伝子導入筋芽細胞の作製 (2010)
  • Author(s): 佐藤暢哲, 井藤彰, 河邉佳典, 藤田英明, 長森英二, 上平正道
  • Organizer: 第47回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議所(北九州市)
  • Year and Date: 2010-07-10
• [Presentation] 機能性磁性ナノ粒子を用いて作製した人工筋組織の機能評価 (2010)
  • Author(s): 山本泰徳, 井藤彰, 河邉佳典, 藤田英明, 長森英二, 上平正道
  • Organizer: 化学工学会第75年会
  • Place of Presentation: 鹿児島大学(鹿児島市)
  • Year and Date: 2010-03-20
• [Presentation] 機能性磁性ナノ粒子を用いて作製した人工筋組織の機能評価 (2010)
  • Author(s): 山本泰徳, 他
  • Organizer: 化学工学会第75年会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2010-03-20
• [Presentation] Construction of Skeletal Muscular Tissue-Like Structures by a Magnetic Force-Based Tissue Engineering Technique. (2009)
  • Author(s): Yasunori Yamamoto, Akira Ito, Hideaki Fujita, Eiji Nagamori, Yoshinori Kawabe, Masamichi Kamihira
  • Organizer: APBioChEC2009
  • Place of Presentation: 神戸市
  • Year and Date: 2009-11-23
• [Presentation] Skeletal Muscle Tissue Engineering Using Functional Magnetite Nanoparticles. (2009)
  • Author(s): Akira Ito, Hirokazu Akiyama, Yasunori Yamamoto, Yoshinori Kawabe, Masamichi Kamihira
  • Organizer: MHS2009
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-11-10
• [Presentation] Skeletal muscle tissue engineering using functional magnetite nanoparticles. (2009)
  • Author(s): Akira Ito, et al.
  • Organizer: MHS2009
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-11-10
• [Presentation] 機能性磁性ナノ粒子を用いた筋組織再生技術によるバイオアクチュエータの開発 (2009)
  • Author(s): 井藤彰, 山本泰徳, 河邉佳典, 藤田英明, 清水一憲, 長森英二, 上平正道
  • Organizer: 第2回化学工学3支部合同北九州大会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-10-31
• [Presentation] 機能性磁性ナノ粒子を用いた筋組織再生技術によるバイオアクチュエーターの開発 (2009)
  • Author(s): 井藤影, 他
  • Organizer: 第2回化学工学3支部合同北九州大会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-10-31
• [Presentation] 磁力を用いたティッシュエンジニアリング技術による筋組織の構築 (2009)
  • Author(s): 井藤彰
  • Organizer: 第61回日本生物工学会大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-25
• [Presentation] 血管新生因子を遺伝子導入した細胞シートの作製と評価 (2009)
  • Author(s): 秋山弘和, 井藤彰, 河邉佳典, 上平正道
  • Organizer: 第61回日本生物工学会大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-23
• [Presentation] 磁力を用いた筋組織構築法の開発 (2009)
  • Author(s): 山本泰徳, 井藤彰, 河邉佳典, 藤田英明, 長森英二, 上平正道
  • Organizer: 第46回化学関連支部合同九州大会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-07-11
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