Project/Area Number |
21687003
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Plant molecular biology/Plant physiology
|
Research Institution | Hokkaido University |
Principal Investigator |
HATSUGAI Noriyuki Hokkaido University, 大学院・医学研究科, 特任助教 (90456848)
|
Co-Investigator(Renkei-kenkyūsha) |
NAGAI Takeharu 北海道大学, 電子科学研究所, 教授 (20311350)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2009: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
|
Keywords | 植物免疫 / 植物微生物間相互作用 / プログラム細胞死 / バイオイメージング / 光イメージング / 植物微生物相互作用 |
Research Abstract |
Plants have developed their own defense strategies, because they have no immune cells. Here we provide a novel mechanism underlying cell-autonomous immunity, which involves the fusion of membranes of a large-central-vacuole with the plasma membrane, resulting in the discharge of vacuolar antibacterial proteins to the outside of the cells where bacteria proliferate. The extracellular fluid that was discharged from the vacuoles of infected leaves had both antibacterial activity and cell-death-inducing activity. Membrane fusion was triggered in a proteasome-dependent manner by the bacterial infection. This novel membrane fusion-based defense strategy provides plants with a mechanism for attacking extracellular bacterial pathogens.
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